In this issue of Cardiac Electrophysiology Clinics, guest editors Drs. Luigi Di Biase and Fengwei Zou bring their considerable expertise to the topic of Atrial Fibrillation in Heart Failure. Top experts discuss atrial fibrillation-induced cardiomyopathy; rate versus rhythm control of atrial fibrillation in heart failure; atrial fibrillation ablation in heart failure with reduced ejection fraction; atrial fibrillation ablation in heart failure with preserved ejection fraction; and much more.