Professor Ronald Sluyter received training in biochemistry and immunology. After completing his BAppSc (University of Technology, Sydney, Australia) and PhD (University of Sydney), he worked as a Research Fellow (2000-2003) and Senior Research Fellow (2003-2007) with the late Professor James Wiley at Nepean Hospital. Since 2008 he has held a tenured Aacdemic position at the University of Wollongong, being promoted to Professor in 2020. He is the author of over 137 original articles and book chapters. He has graduated over 16 graduate students.Dr Jennie Cederholm received training in biomedical science, physiology and neuroscience. After completing her MSc (Linköping University, Sweden) and PhD (University of South Australia, Adelaide), she worked as a Research Officer (2007-2011) in what is today Neuroscience Research Australia (NeuRA). In 2011, she joined the laboratory of Professor Gary Housley as a Postdoctoral Fellow at UNSW Sydney. She holds a tenured Academic position since 2020 and was promoted to Senior Lecturer in 2021. She is the author of 26 refereed scientific publications. She has graduated 8 Honours students and is currently supervising 2 Honours students and a PhD student. Associate Professor Leanne Stokes received training in physiology and pharmacology. After completing her MRes and PhD in immunology (University of Birmingham, UK), she worked as a postdoctoral researcher officer (2003-2006) at the University of Sheffield. In 2007, she joined the laboratory of the late Professor James Wiley as a Postdoctoral Fellow at University of Sydney before gaining independence through an NHMRC new investigator award (2009). In 2013 she moved to RMIT to take a position as a Vice-Chancellors Research Fellow (2013-2015). She holds a tenured Academic position since 2015 at the University of East Anglia (UEA) and was promoted to Associate Professor in 2020. She is the author of 54 refereed scientific publications. She has graduated 3 PhD students and is currently supervising an MSci student and a PhD student. Prof. H Ulrich is Full Professor and Head of the Laboratory of Neuroscience at the Institute of Chemistry of the University of São Paulo, Brazil. He is a pioneer in the investigation of purinergic signaling in neuroinflammation, neurogenesis and neurodegeneration. He is a founding member of the Brazilian Purine Club (Brazilian Society of Purinergic Signaling), Vice-President (2010-2012) and President (2012-2018 and 2021-2024) of the society and has chaired many congresses of the Brazilian Purine Club. He is Associate Editor of several peer-reviewed journals, including Purinergic Signalling. He has published more than 260 peer-reviewed manuscripts (>10,000 citations, H index: 52), 31 book articles and 5 books and is inventor in various patents. He was recently awarded with the Brazil Fulbright Global Health Chair at Rutgers Medical School. Associate Professor Srdjan Vlajkovic received training in medicine, immunology, and neuroscience. He worked at the Department of Physiology, University of Auckland as a Research Fellow and Senior Research Fellow and now holds a tenured academic position at the University of Auckland. He authored 88 original articles and book chapters and supervised 38 graduate students to completion. Dr Vlajkovic guest-edited several Special Issues in international journals and is currently the Academic Editor of the International Journal of Molecular Sciences and Frontiers journals.Prof. Y Tang is a Full Professor and Dean of the School of Health and Rehabilitation of Chengdu University of Traditional Chinese Medicine. He is the founding member of the International Joint Research Center on Purinergic Signalling of Sichuan Province of China and the Co-chair of China Purine Club. He is Associate Editor of Purinergic Signalling. He is the author of over 157 publications and book chapters. He has graduated over 29 graduate students.

• Part I - Introduction to extracellular ATP1. History of ATP and purinergic signalling2. Extracellular ATP in normal biologyPart II – Molecular biology of extracellular ATP signalling3. Extracellular ATP4. P2X receptors5. P2Y receptors6. Regulation of extracellular ATP by ectonucleotidasesPart III – Extracellular ATP in organ function7. Extracellular ATP and the oral cavity8. Extracellular ATP and blood vessels9. Extracellular ATP and the heart and carotid body10. Extracellular ATP and the lung11. Extracellular ATP and metabolism12. Extracellular ATP and the gastrointestinal tract13. Extracellular ATP and the liver14. Extracellular ATP and the pancreas15. Extracellular ATP and the kidneys16. Extracellular ATP and the bladder17. Extracellular ATP and the central nervous system18. Extracellular ATP and the peripheral nervous system19. Extracellular ATP and the eye20. Extracellular ATP and the ear21. Extracellular ATP and the reproductive organs22. Extracellular ATP and the skin23. Extracellular ATP and the bone24. Extracellular ATP and skeletal muscle25. Extracellular ATP and haematopoietic stem and progenitor cells26. Extracellular ATP and platelets27. Extracellular ATP and red blood cells28. Extracellular ATP and innate immune cells29. Extracellular ATP and adaptive immune cellsPart IV - Pharmacology of extracellular ATP signalling30. Extracellular ATP and P2X receptors)31. Extracellular ATP and P2Y receptorsPart V - Extracellular ATP in non-mammalian biology32. Extracellular ATP in fish33. Extracellular ATP in primitive species34. Extracellular ATP in plantsPart VI - Extracellular ATP in Disease35. Extracellular ATP in aged-related disorders36. Extracellular ATP in cardiovascular disorders37. Extracellular ATP in respiratory disorders38. Extracellular ATP in gastrointestinal disorders40. 39. Extracellular ATP in brain diseases41. Extracellular ATP in neurodegenerative disorders42. Extracellular ATP in psychiatric disorders43. Extracellular ATP in pain44. Extracellular ATP in other sensory disorders45. Extracellular ATP in infectious disease46. Extracellular ATP in inflammatory disorders47. Extracellular ATP in cancer48. Extracellular ATP and future directions

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Professor Ronald Sluyter received training in biochemistry and immunology. After completing his BAppSc (University of Technology, Sydney, Australia) and PhD (University of Sydney), he worked as a Research Fellow (2000-2003) and Senior Research Fellow (2003-2007) with the late Professor James Wiley at Nepean Hospital. Since 2008 he has held a tenured Aacdemic position at the University of Wollongong, being promoted to Professor in 2020. He is the author of over 137 original articles and book chapters. He has graduated over 16 graduate students.Dr Jennie Cederholm received training in biomedical science, physiology and neuroscience. After completing her MSc (Linköping University, Sweden) and PhD (University of South Australia, Adelaide), she worked as a Research Officer (2007-2011) in what is today Neuroscience Research Australia (NeuRA). In 2011, she joined the laboratory of Professor Gary Housley as a Postdoctoral Fellow at UNSW Sydney. She holds a tenured Academic position since 2020 and was promoted to Senior Lecturer in 2021. She is the author of 26 refereed scientific publications. She has graduated 8 Honours students and is currently supervising 2 Honours students and a PhD student. Associate Professor Leanne Stokes received training in physiology and pharmacology. After completing her MRes and PhD in immunology (University of Birmingham, UK), she worked as a postdoctoral researcher officer (2003-2006) at the University of Sheffield. In 2007, she joined the laboratory of the late Professor James Wiley as a Postdoctoral Fellow at University of Sydney before gaining independence through an NHMRC new investigator award (2009). In 2013 she moved to RMIT to take a position as a Vice-Chancellors Research Fellow (2013-2015). She holds a tenured Academic position since 2015 at the University of East Anglia (UEA) and was promoted to Associate Professor in 2020. She is the author of 54 refereed scientific publications. She has graduated 3 PhD students and is currently supervising an MSci student and a PhD student. Prof. H Ulrich is Full Professor and Head of the Laboratory of Neuroscience at the Institute of Chemistry of the University of São Paulo, Brazil. He is a pioneer in the investigation of purinergic signaling in neuroinflammation, neurogenesis and neurodegeneration. He is a founding member of the Brazilian Purine Club (Brazilian Society of Purinergic Signaling), Vice-President (2010-2012) and President (2012-2018 and 2021-2024) of the society and has chaired many congresses of the Brazilian Purine Club. He is Associate Editor of several peer-reviewed journals, including Purinergic Signalling. He has published more than 260 peer-reviewed manuscripts (>10,000 citations, H index: 52), 31 book articles and 5 books and is inventor in various patents. He was recently awarded with the Brazil Fulbright Global Health Chair at Rutgers Medical School. Associate Professor Srdjan Vlajkovic received training in medicine, immunology, and neuroscience. He worked at the Department of Physiology, University of Auckland as a Research Fellow and Senior Research Fellow and now holds a tenured academic position at the University of Auckland. He authored 88 original articles and book chapters and supervised 38 graduate students to completion. Dr Vlajkovic guest-edited several Special Issues in international journals and is currently the Academic Editor of the International Journal of Molecular Sciences and Frontiers journals.Prof. Y Tang is a Full Professor and Dean of the School of Health and Rehabilitation of Chengdu University of Traditional Chinese Medicine. He is the founding member of the International Joint Research Center on Purinergic Signalling of Sichuan Province of China and the Co-chair of China Purine Club. He is Associate Editor of Purinergic Signalling. He is the author of over 157 publications and book chapters. He has graduated over 29 graduate students.

• Part I - Introduction to extracellular ATP1. History of ATP and purinergic signalling2. Extracellular ATP in normal biologyPart II – Molecular biology of extracellular ATP signalling3. Extracellular ATP4. P2X receptors5. P2Y receptors6. Regulation of extracellular ATP by ectonucleotidasesPart III – Extracellular ATP in organ function7. Extracellular ATP and the oral cavity8. Extracellular ATP and blood vessels9. Extracellular ATP and the heart and carotid body10. Extracellular ATP and the lung11. Extracellular ATP and metabolism12. Extracellular ATP and the gastrointestinal tract13. Extracellular ATP and the liver14. Extracellular ATP and the pancreas15. Extracellular ATP and the kidneys16. Extracellular ATP and the bladder17. Extracellular ATP and the central nervous system18. Extracellular ATP and the peripheral nervous system19. Extracellular ATP and the eye20. Extracellular ATP and the ear21. Extracellular ATP and the reproductive organs22. Extracellular ATP and the skin23. Extracellular ATP and the bone24. Extracellular ATP and skeletal muscle25. Extracellular ATP and haematopoietic stem and progenitor cells26. Extracellular ATP and platelets27. Extracellular ATP and red blood cells28. Extracellular ATP and innate immune cells29. Extracellular ATP and adaptive immune cellsPart IV - Pharmacology of extracellular ATP signalling30. Extracellular ATP and P2X receptors)31. Extracellular ATP and P2Y receptorsPart V - Extracellular ATP in non-mammalian biology32. Extracellular ATP in fish33. Extracellular ATP in primitive species34. Extracellular ATP in plantsPart VI - Extracellular ATP in Disease35. Extracellular ATP in aged-related disorders36. Extracellular ATP in cardiovascular disorders37. Extracellular ATP in respiratory disorders38. Extracellular ATP in gastrointestinal disorders40. 39. Extracellular ATP in brain diseases41. Extracellular ATP in neurodegenerative disorders42. Extracellular ATP in psychiatric disorders43. Extracellular ATP in pain44. Extracellular ATP in other sensory disorders45. Extracellular ATP in infectious disease46. Extracellular ATP in inflammatory disorders47. Extracellular ATP in cancer48. Extracellular ATP and future directions

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Professor Ronald Sluyter received training in biochemistry and immunology. After completing his BAppSc (University of Technology, Sydney, Australia) and PhD (University of Sydney), he worked as a Research Fellow (2000-2003) and Senior Research Fellow (2003-2007) with the late Professor James Wiley at Nepean Hospital. Since 2008 he has held a tenured Aacdemic position at the University of Wollongong, being promoted to Professor in 2020. He is the author of over 137 original articles and book chapters. He has graduated over 16 graduate students.Dr Jennie Cederholm received training in biomedical science, physiology and neuroscience. After completing her MSc (Linköping University, Sweden) and PhD (University of South Australia, Adelaide), she worked as a Research Officer (2007-2011) in what is today Neuroscience Research Australia (NeuRA). In 2011, she joined the laboratory of Professor Gary Housley as a Postdoctoral Fellow at UNSW Sydney. She holds a tenured Academic position since 2020 and was promoted to Senior Lecturer in 2021. She is the author of 26 refereed scientific publications. She has graduated 8 Honours students and is currently supervising 2 Honours students and a PhD student. Associate Professor Leanne Stokes received training in physiology and pharmacology. After completing her MRes and PhD in immunology (University of Birmingham, UK), she worked as a postdoctoral researcher officer (2003-2006) at the University of Sheffield. In 2007, she joined the laboratory of the late Professor James Wiley as a Postdoctoral Fellow at University of Sydney before gaining independence through an NHMRC new investigator award (2009). In 2013 she moved to RMIT to take a position as a Vice-Chancellors Research Fellow (2013-2015). She holds a tenured Academic position since 2015 at the University of East Anglia (UEA) and was promoted to Associate Professor in 2020. She is the author of 54 refereed scientific publications. She has graduated 3 PhD students and is currently supervising an MSci student and a PhD student. Prof. H Ulrich is Full Professor and Head of the Laboratory of Neuroscience at the Institute of Chemistry of the University of São Paulo, Brazil. He is a pioneer in the investigation of purinergic signaling in neuroinflammation, neurogenesis and neurodegeneration. He is a founding member of the Brazilian Purine Club (Brazilian Society of Purinergic Signaling), Vice-President (2010-2012) and President (2012-2018 and 2021-2024) of the society and has chaired many congresses of the Brazilian Purine Club. He is Associate Editor of several peer-reviewed journals, including Purinergic Signalling. He has published more than 260 peer-reviewed manuscripts (>10,000 citations, H index: 52), 31 book articles and 5 books and is inventor in various patents. He was recently awarded with the Brazil Fulbright Global Health Chair at Rutgers Medical School. Associate Professor Srdjan Vlajkovic received training in medicine, immunology, and neuroscience. He worked at the Department of Physiology, University of Auckland as a Research Fellow and Senior Research Fellow and now holds a tenured academic position at the University of Auckland. He authored 88 original articles and book chapters and supervised 38 graduate students to completion. Dr Vlajkovic guest-edited several Special Issues in international journals and is currently the Academic Editor of the International Journal of Molecular Sciences and Frontiers journals.Prof. Y Tang is a Full Professor and Dean of the School of Health and Rehabilitation of Chengdu University of Traditional Chinese Medicine. He is the founding member of the International Joint Research Center on Purinergic Signalling of Sichuan Province of China and the Co-chair of China Purine Club. He is Associate Editor of Purinergic Signalling. He is the author of over 157 publications and book chapters. He has graduated over 29 graduate students.

• Part I - Introduction to extracellular ATP1. History of ATP and purinergic signalling2. Extracellular ATP in normal biologyPart II – Molecular biology of extracellular ATP signalling3. Extracellular ATP4. P2X receptors5. P2Y receptors6. Regulation of extracellular ATP by ectonucleotidasesPart III – Extracellular ATP in organ function7. Extracellular ATP and the oral cavity8. Extracellular ATP and blood vessels9. Extracellular ATP and the heart and carotid body10. Extracellular ATP and the lung11. Extracellular ATP and metabolism12. Extracellular ATP and the gastrointestinal tract13. Extracellular ATP and the liver14. Extracellular ATP and the pancreas15. Extracellular ATP and the kidneys16. Extracellular ATP and the bladder17. Extracellular ATP and the central nervous system18. Extracellular ATP and the peripheral nervous system19. Extracellular ATP and the eye20. Extracellular ATP and the ear21. Extracellular ATP and the reproductive organs22. Extracellular ATP and the skin23. Extracellular ATP and the bone24. Extracellular ATP and skeletal muscle25. Extracellular ATP and haematopoietic stem and progenitor cells26. Extracellular ATP and platelets27. Extracellular ATP and red blood cells28. Extracellular ATP and innate immune cells29. Extracellular ATP and adaptive immune cellsPart IV - Pharmacology of extracellular ATP signalling30. Extracellular ATP and P2X receptors)31. Extracellular ATP and P2Y receptorsPart V - Extracellular ATP in non-mammalian biology32. Extracellular ATP in fish33. Extracellular ATP in primitive species34. Extracellular ATP in plantsPart VI - Extracellular ATP in Disease35. Extracellular ATP in aged-related disorders36. Extracellular ATP in cardiovascular disorders37. Extracellular ATP in respiratory disorders38. Extracellular ATP in gastrointestinal disorders40. 39. Extracellular ATP in brain diseases41. Extracellular ATP in neurodegenerative disorders42. Extracellular ATP in psychiatric disorders43. Extracellular ATP in pain44. Extracellular ATP in other sensory disorders45. Extracellular ATP in infectious disease46. Extracellular ATP in inflammatory disorders47. Extracellular ATP in cancer48. Extracellular ATP and future directions

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