Valentin Fuster, MD, PhD, former Chairman of the American Heart Association's Committee on Vascular Lesions, Assessing and Modifying the Vulnerable Atherosclerotic Plaque explores the most cutting-edge developments in a field grown richer through technological advances.William Insull, Jr., Professor of Medicine and Pediatrics/Director, Lipid Research Clinic, Division of Atherosclerosis and Lipoprotein Metabolism, Department of Medicine, Baylor College of Medicine and The Methodist Hospital.

• Historical PerspectiveContributorsChapter 1. Evolving Concepts of AtherothrombosisValentin Fuster, MD, PhD and Roberto Corti, MDChapter 2. Cerebrovascular Diseases: Pathophysiology and ManagementDebabrata Mukherjee, MD and Jay S. Yadav, MDChapter 3. Aortic Arch Vulnerable Plaques: UpdatePierre Amarenco, MD and Ariel Cohen, MD, PhDChapter 4. The Vulnerable Atherosclerotic Plaque in Peripheral Vascular DiseaseMichael L. Marin, MD, Larry H. Hollier, MD, Valentin Fuster, MD, PhD, and Jeffrey Goldman, MDPanel Discussion I. Overview of Pathology: Clinical Correlations of AtherosclerosisChapter 5. Thermography: A Novel Approach for Identification of Plaques at Risk of Rupture and/or ThrombosisMohammad Madjid, MD, Morteza Naghavi, MD, James T. Willerson, MD, and Ward Casscells, MDChapter 6. Intravascular Ultrasound and Plaque Vulnerability: Evidence of a Systemic Disease ProcessPaul Schoenhagen, MD and Steven E. Nissen, MD, FACCChapter 7. Intracoronary Angioscopy to Detect Vulnerable Plaques: A Technique Whose Time Has Come?Sergio Waxman, MDChapter 8. Electron Beam Computed Tomography in Assessing the Vulnerable Atherosclerotic PlaqueRobert A. O'Rourke, MDChapter 9. Multirow-Detector Helical Computed TomographyChristoph R. Becker, MD, Uwe J. Schoepf, MD, and Maximilian F. Reiser, MDPanel Discussion IIA. Overview of Imaging: Coronary AtherosclerosisChapter 10. Imaging of the High-Risk Plaque Using Magnetic Resonance ImagingZahi A. Fayad, PhD and Valentin Fuster, MD, PhDChapter 11. Cardiovascular Imaging with Optical Coherence TomographyMark E. Brezinski, MD, PhD and James Fujimoto, PhDPanel Discussion IIB. Overview of Imaging: Atherosclerotic Regions and Imaging ModalitiesChapter 12. Plaque Instability and Remodeling: Mechanisms and Possible MisconceptionsTrine-Line Korsholm, MS, Gerard Pasterkamp, MD, PhD, MSc, and Erling Falk, MD, PhDChapter 13. Structural and Cellular Components of the Vulnerable Plaque: Extracellular MatrixRenu Virmani, MD, Frank D. Kolodgie, PhD, Allen P. Burke, MD, Andrew Farb, MD, and Thomas N. Wight, PhDChapter 14. Structural and Cellular Components of the Vulnerable Plaque: Inflammatory CellsAllard C. van der Wal, MD, PhD, Mischa A. Houtkamp, MSc, Onno J. de Boer, PhD, and Anton E. Becker, MD, PhDPanel Discussion III. Structural and Cellular Components of the Vulnerable Atherosclerotic PlaqueChapter 15. Stress and Strain: Biomechanical Guides for Imaging Plaque StabilityHayden Huang, DSc and Richard T. Lee, MDChapter 16. Endothelium, Flow, and AtherothrombosisRoberto Corti, MD, Lina Badimon, PhD, Valentin Fuster, MD, PhD, and Juan Jose Badimon, PhDChapter 17. Activities that Trigger Plaque DisruptionJagmeet P. Singh, MD, DM, PhD, James Januzzi, MD, and James E. Muller, MDPanel Discussion IV. Mechanical Forces in Plaque DisruptionChapter 18. Matrix Metalloproteinases and Their InhibitorsUwe Schönbeck, PhD and Peter Libby, MDChapter 19. Calcium Deposition in Vulnerable Atherosclerotic Plaques: Pathophysiologic Mechanisms and Potential Implications in the Acute Coronary SyndromesPedro R. Moreno, MDPanel Discussion V. Regulation of Functional Components of the Vulnerable PlaqueIndex

Valentin Fuster, MD, PhD, former Chairman of the American Heart Association's Committee on Vascular Lesions, Assessing and Modifying the Vulnerable Atherosclerotic Plaque explores the most cutting-edge developments in a field grown richer through technological advances.William Insull, Jr., Professor of Medicine and Pediatrics/Director, Lipid Research Clinic, Division of Atherosclerosis and Lipoprotein Metabolism, Department of Medicine, Baylor College of Medicine and The Methodist Hospital.

• Historical PerspectiveContributorsChapter 1. Evolving Concepts of AtherothrombosisValentin Fuster, MD, PhD and Roberto Corti, MDChapter 2. Cerebrovascular Diseases: Pathophysiology and ManagementDebabrata Mukherjee, MD and Jay S. Yadav, MDChapter 3. Aortic Arch Vulnerable Plaques: UpdatePierre Amarenco, MD and Ariel Cohen, MD, PhDChapter 4. The Vulnerable Atherosclerotic Plaque in Peripheral Vascular DiseaseMichael L. Marin, MD, Larry H. Hollier, MD, Valentin Fuster, MD, PhD, and Jeffrey Goldman, MDPanel Discussion I. Overview of Pathology: Clinical Correlations of AtherosclerosisChapter 5. Thermography: A Novel Approach for Identification of Plaques at Risk of Rupture and/or ThrombosisMohammad Madjid, MD, Morteza Naghavi, MD, James T. Willerson, MD, and Ward Casscells, MDChapter 6. Intravascular Ultrasound and Plaque Vulnerability: Evidence of a Systemic Disease ProcessPaul Schoenhagen, MD and Steven E. Nissen, MD, FACCChapter 7. Intracoronary Angioscopy to Detect Vulnerable Plaques: A Technique Whose Time Has Come?Sergio Waxman, MDChapter 8. Electron Beam Computed Tomography in Assessing the Vulnerable Atherosclerotic PlaqueRobert A. O'Rourke, MDChapter 9. Multirow-Detector Helical Computed TomographyChristoph R. Becker, MD, Uwe J. Schoepf, MD, and Maximilian F. Reiser, MDPanel Discussion IIA. Overview of Imaging: Coronary AtherosclerosisChapter 10. Imaging of the High-Risk Plaque Using Magnetic Resonance ImagingZahi A. Fayad, PhD and Valentin Fuster, MD, PhDChapter 11. Cardiovascular Imaging with Optical Coherence TomographyMark E. Brezinski, MD, PhD and James Fujimoto, PhDPanel Discussion IIB. Overview of Imaging: Atherosclerotic Regions and Imaging ModalitiesChapter 12. Plaque Instability and Remodeling: Mechanisms and Possible MisconceptionsTrine-Line Korsholm, MS, Gerard Pasterkamp, MD, PhD, MSc, and Erling Falk, MD, PhDChapter 13. Structural and Cellular Components of the Vulnerable Plaque: Extracellular MatrixRenu Virmani, MD, Frank D. Kolodgie, PhD, Allen P. Burke, MD, Andrew Farb, MD, and Thomas N. Wight, PhDChapter 14. Structural and Cellular Components of the Vulnerable Plaque: Inflammatory CellsAllard C. van der Wal, MD, PhD, Mischa A. Houtkamp, MSc, Onno J. de Boer, PhD, and Anton E. Becker, MD, PhDPanel Discussion III. Structural and Cellular Components of the Vulnerable Atherosclerotic PlaqueChapter 15. Stress and Strain: Biomechanical Guides for Imaging Plaque StabilityHayden Huang, DSc and Richard T. Lee, MDChapter 16. Endothelium, Flow, and AtherothrombosisRoberto Corti, MD, Lina Badimon, PhD, Valentin Fuster, MD, PhD, and Juan Jose Badimon, PhDChapter 17. Activities that Trigger Plaque DisruptionJagmeet P. Singh, MD, DM, PhD, James Januzzi, MD, and James E. Muller, MDPanel Discussion IV. Mechanical Forces in Plaque DisruptionChapter 18. Matrix Metalloproteinases and Their InhibitorsUwe Schönbeck, PhD and Peter Libby, MDChapter 19. Calcium Deposition in Vulnerable Atherosclerotic Plaques: Pathophysiologic Mechanisms and Potential Implications in the Acute Coronary SyndromesPedro R. Moreno, MDPanel Discussion V. Regulation of Functional Components of the Vulnerable PlaqueIndex

Valentin Fuster, MD, PhD, former Chairman of the American Heart Association's Committee on Vascular Lesions, Assessing and Modifying the Vulnerable Atherosclerotic Plaque explores the most cutting-edge developments in a field grown richer through technological advances.William Insull, Jr., Professor of Medicine and Pediatrics/Director, Lipid Research Clinic, Division of Atherosclerosis and Lipoprotein Metabolism, Department of Medicine, Baylor College of Medicine and The Methodist Hospital.

• Historical PerspectiveContributorsChapter 1. Evolving Concepts of AtherothrombosisValentin Fuster, MD, PhD and Roberto Corti, MDChapter 2. Cerebrovascular Diseases: Pathophysiology and ManagementDebabrata Mukherjee, MD and Jay S. Yadav, MDChapter 3. Aortic Arch Vulnerable Plaques: UpdatePierre Amarenco, MD and Ariel Cohen, MD, PhDChapter 4. The Vulnerable Atherosclerotic Plaque in Peripheral Vascular DiseaseMichael L. Marin, MD, Larry H. Hollier, MD, Valentin Fuster, MD, PhD, and Jeffrey Goldman, MDPanel Discussion I. Overview of Pathology: Clinical Correlations of AtherosclerosisChapter 5. Thermography: A Novel Approach for Identification of Plaques at Risk of Rupture and/or ThrombosisMohammad Madjid, MD, Morteza Naghavi, MD, James T. Willerson, MD, and Ward Casscells, MDChapter 6. Intravascular Ultrasound and Plaque Vulnerability: Evidence of a Systemic Disease ProcessPaul Schoenhagen, MD and Steven E. Nissen, MD, FACCChapter 7. Intracoronary Angioscopy to Detect Vulnerable Plaques: A Technique Whose Time Has Come?Sergio Waxman, MDChapter 8. Electron Beam Computed Tomography in Assessing the Vulnerable Atherosclerotic PlaqueRobert A. O'Rourke, MDChapter 9. Multirow-Detector Helical Computed TomographyChristoph R. Becker, MD, Uwe J. Schoepf, MD, and Maximilian F. Reiser, MDPanel Discussion IIA. Overview of Imaging: Coronary AtherosclerosisChapter 10. Imaging of the High-Risk Plaque Using Magnetic Resonance ImagingZahi A. Fayad, PhD and Valentin Fuster, MD, PhDChapter 11. Cardiovascular Imaging with Optical Coherence TomographyMark E. Brezinski, MD, PhD and James Fujimoto, PhDPanel Discussion IIB. Overview of Imaging: Atherosclerotic Regions and Imaging ModalitiesChapter 12. Plaque Instability and Remodeling: Mechanisms and Possible MisconceptionsTrine-Line Korsholm, MS, Gerard Pasterkamp, MD, PhD, MSc, and Erling Falk, MD, PhDChapter 13. Structural and Cellular Components of the Vulnerable Plaque: Extracellular MatrixRenu Virmani, MD, Frank D. Kolodgie, PhD, Allen P. Burke, MD, Andrew Farb, MD, and Thomas N. Wight, PhDChapter 14. Structural and Cellular Components of the Vulnerable Plaque: Inflammatory CellsAllard C. van der Wal, MD, PhD, Mischa A. Houtkamp, MSc, Onno J. de Boer, PhD, and Anton E. Becker, MD, PhDPanel Discussion III. Structural and Cellular Components of the Vulnerable Atherosclerotic PlaqueChapter 15. Stress and Strain: Biomechanical Guides for Imaging Plaque StabilityHayden Huang, DSc and Richard T. Lee, MDChapter 16. Endothelium, Flow, and AtherothrombosisRoberto Corti, MD, Lina Badimon, PhD, Valentin Fuster, MD, PhD, and Juan Jose Badimon, PhDChapter 17. Activities that Trigger Plaque DisruptionJagmeet P. Singh, MD, DM, PhD, James Januzzi, MD, and James E. Muller, MDPanel Discussion IV. Mechanical Forces in Plaque DisruptionChapter 18. Matrix Metalloproteinases and Their InhibitorsUwe Schönbeck, PhD and Peter Libby, MDChapter 19. Calcium Deposition in Vulnerable Atherosclerotic Plaques: Pathophysiologic Mechanisms and Potential Implications in the Acute Coronary SyndromesPedro R. Moreno, MDPanel Discussion V. Regulation of Functional Components of the Vulnerable PlaqueIndex