This book constitutes the proceedings of the 42nd SGAI International Conference on Innovative Techniques and Applications of Artificial Intelligence, AI 2022, which was held in Cambridge, UK, in December 2022.The 20 full papers and 11 short papers presented in this volume were carefully reviewed and selected from 40 submissions. The volume includes technical papers presenting new and innovative developments in the field as well as application papers presenting innovative applications of AI techniques in a number of subject domains. The papers are organized in the following topical sections: best technical paper; best application paper; AI for health and medicine; AI for scientific discovery and decision making; AI for industrial applications; feasibility studies of applied AI; and short papers.