This book presents proceedings of the 16th International Conference on Intelligent Multimodal Communication and Learning Technologies (IMCL2025), held on November 19–21, 2025, which provided a dedicated international forum to discuss, analyze, and critically assess current trends, challenges, and opportunities in intelligent multimodal and learning technologies.Intelligent multimodal communication and learning technologies are today at the core of almost all sectors of society. Not only younger generations of learners, but also educators, professionals, and lifelong learners increasingly expect flexible, digital, and multimodal learning environments. At the same time, new ideas, technologies, and AI-driven solutions emerge almost daily, further accelerating this transformation.Since its beginning in 2006, this conference has been devoted to new approaches in interactive mobile technologies with a strong focus on education and training. Over the years, IMCL has evolved into a well-recognized platform for the exchange of scientific research results, emerging technological trends, and practical experiences, as well as for the dissemination of good practices in technology-enhanced learning.The book addresses a broad and interdisciplinary audience, including policymakers, academics, educators, researchers in pedagogy and learning sciences, schoolteachers, learning technology developers, industry professionals, and lifelong learning practitioners.