This book constitutes the refereed proceedings of the 5th International Conference on Artificial Intelligence and Knowledge Processing, AIKP 2025, held in Hyderabad, India, during October 23–25, 2025.The 22 full papers included in this book were carefully reviewed and selected from 111 submissions. They explore a broad spectrum of themes including machine learning, natural language processing, computer vision, robotics, data science, quantum AI, cognitive computing, and ethical AI.