This book constitutes the refereed proceedings of the First International Conference on Artificial Intelligence and its Application, ICAIA 2023, held in Pune, India, during December 18–19, 2023.The 37 full papers and 3 short papers presented in these two volumes were carefully reviewed and selected from 217 submissions. The conference focused on three primary domains: Use of AI in Health Care; Machine Vision and Image Processing; Automated and Digital Manufacturing Systems.