ARF Family GTPases

Häftad, Engelska, 2010

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For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.

Produktinformation

Utgivningsdatum2010-12-30
Mått155 x 235 x 21 mm
Vikt581 g
FormatHäftad
SpråkEngelska
SerieProteins and Cell Regulation
Antal sidor350
Upplaga2003
FörlagSpringer
ISBN9789048164691

Tillhör följande kategorier

Biovetenskap inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik

The Arf Family Tree.- The GDP/GTP Cycle of Arf Proteins.- Arf and Phospholipids.- The Sec7 Family of Arf Guanine Nucleotide Exchange Factors.- Large Arf GEFs of the Golgi Complex.- BIG1 and BIG2: Brefeldin A-Inhibited Exchange Factors for Arfs.- Arf GTPase-Activating Protein 1.- GIT Proteins: Arf Gaps and Signaling Scaffolds.- Paxillin-Associated Arf GAPs.- Activation of Cholera Toxin and E. Coli Heat-Labile Enterotoxin (LT) by Arf.- Phospholipase D, Arfaptins and Arfophilin.- Coat Proteins.- Heterotetrameric Coat Protein-Arf Interactions.- Arf6.- A Role for Arf6 in G Protein-coupled Receptor Desensitization.- Arf-Like Proteins.

From the reviews: "A journey into a deeper understanding of the diversity of cellular controls exerted by the ARF family. The writing is so clear and well developed ... it will allow newcomers in the area to dive into a dynamic area of molecular and cellular science. ... the reader is treated to a wealth of discussion and critique on how ARFs modulate processes such as membrane fusion, vesicular transport, cell migration and receptor activity. This is an outstanding text for everyone with an interest in cell biology." (M. Thompson, Cell Biochemistry and Function, Vol. 23 (4), 2005)