This book constitutes the refereed proceedings of the 5th International Conference on Applied Machine Learning and Data Analytics, AMLDA 2022, held in Reynosa, Tamaulipas, Mexico, during December 22–23, 2022. The 16 full papers and 4 short papers included in this book were carefully reviewed and selected from 89 submissions. They were organized in topical sections as follows: Machine learning, Healthcare and medical imaging informatics; biometrics; forensics; precision agriculture; risk management; robotics and satellite imaging.