The two-volume set CCIS 2236 and 2237 constitutes the refereed proceedings of the 7th International Conference on Applied Informatics, ICAI 2024, held in Vina del Mar, Chile, during October 24–26, 2024.The 39 full papers presented in these proceedings were carefully reviewed and selected from 123 submissions. The papers were organized in the following topical sections:Part I - Artificial Intelligence; Bioinformatics; Cloud Computing; Data Analysis; Decision Systems; and Game Development.Part II - Health Care Information Systems; Interdisciplinary Information Studies; Learning Management Systems; Natural Language Processing; Social and Behavioral Applications; Software and Systems Modeling; and Software Architectures.