Applications of Vibrational Spectroscopy in Pharmaceutical Research and Development

Inbunden, Engelska, 2007

AvDon E. Pivonka,John M. Chalmers,Peter R. Griffiths

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Although vibrational spectroscopy is a critical technology within the pharmaceutical industry, currently the literature regarding its applications in the field is fragmented. At present there is no single volume that brings together the diverse aspects of vibrational spectroscopy at a level that will provide value to the dedicated spectroscopist as well as to the synthetic, development and medicinal based chemists, alike. This volume aims to present key themes, established and emerging, within current research as well as presenting detailed contributions on the instrumentation, methodology, data treatment, and applications associated within this area of research. It will provide a consolidated "road map" to the practice of this science within the industry.

Produktinformation

Utgivningsdatum2007-03-23
Mått198 x 252 x 25 mm
Vikt1 107 g
FormatInbunden
SpråkEngelska
Antal sidor384
FörlagJohn Wiley & Sons Inc
ISBN9780470870877

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Farmakologi inom Medicin
Kemi inom Naturvetenskap och teknik
Tillverkningsteknik inom Naturvetenskap och teknik

Part One: Introduction Introduction to Vibrational Spectroscopy Peter R. GriffithsPart Two: Drug DiscoverySampling Techniques and Fiber-Optic Probes John M. Chalmers and Peter R. GriffithsVibrational Spectroscopy in the Discovery Phase Component of Pharmaceutical Research Don E. PivonkaApplications of Vibrational Spectroscopy to Combinatorial Chemistry Don E. PivonkaVibrational Spectroscopic Analysis for the Determination of Structure-Activity Relationships (SARs) in Molecular Binding Don E. Pivonka and Isao NodaApplications of Vibrational Optical Activity in the Pharmaceutical Industry Laurence A. Nafie and Rina K. DukorCharacterization and Optimization of Chemical Synthesis Using Real-Time Vibrational Spectroscopy Fadi Homsi, Paul Barrett, Jian Wang and Roel FerwerdaPart Three: Drug DevelopmentInfrared and Raman Spectroscopy for Process Development George Zhou, Robert Guenard and Zhihong GeThe Analysis of Pharmaceutical Substances and Formulated Products by Vibrational Spectroscopy Don Clark and Alexander PysikRaman Analysis of Pharmaceuticals David E. Bugay, Jan-Olav Henck, Michael L. Longmire and Fiona C. ThorleyVibrational Spectroscopy of Solid-State Forms - Introduction, Principles and Overview Terry L. Threlfall and John M. ChalmersVibrational Spectroscopy of Solid-State Forms - Applications and Examples David H. Igo and Pingyun ChenPharmaceutical Applications of Chemical Mapping and Imaging Don Clark, Mark Henson, Fred LaPlant, Slobodan Sasic and Lin ZhangTerahertz Spectroscopy for Pharmaceutical Applications Mike Claybourn, Husheng Yang, Lubomir Gradinarsky, Jonas Johansson and Staffan FolestadPart Four: ConclusionsHistory, Trends and Prognostications Peter R. Griffiths, John M. Chalmers and Don E. Pivonka