Applications of Vibrational Spectroscopy in Pharmaceutical Research and Development

Dr Don Pivonka, Principal Chemist I, AstraZeneca Pharmaceuticals, Wilmington, USA. Professor P.R. Giffiths, University of Idaho, USA. Mr J.M. Chalmers, Nottingham University, UK.

• Part One: Introduction Introduction to Vibrational Spectroscopy Peter R. GriffithsPart Two: Drug DiscoverySampling Techniques and Fiber-Optic Probes John M. Chalmers and Peter R. GriffithsVibrational Spectroscopy in the Discovery Phase Component of Pharmaceutical Research Don E. PivonkaApplications of Vibrational Spectroscopy to Combinatorial Chemistry Don E. PivonkaVibrational Spectroscopic Analysis for the Determination of Structure-Activity Relationships (SARs) in Molecular Binding Don E. Pivonka and Isao NodaApplications of Vibrational Optical Activity in the Pharmaceutical Industry Laurence A. Nafie and Rina K. DukorCharacterization and Optimization of Chemical Synthesis Using Real-Time Vibrational Spectroscopy Fadi Homsi, Paul Barrett, Jian Wang and Roel FerwerdaPart Three: Drug DevelopmentInfrared and Raman Spectroscopy for Process Development George Zhou, Robert Guenard and Zhihong GeThe Analysis of Pharmaceutical Substances and Formulated Products by Vibrational Spectroscopy Don Clark and Alexander PysikRaman Analysis of Pharmaceuticals David E. Bugay, Jan-Olav Henck, Michael L. Longmire and Fiona C. ThorleyVibrational Spectroscopy of Solid-State Forms - Introduction, Principles and Overview Terry L. Threlfall and John M. ChalmersVibrational Spectroscopy of Solid-State Forms - Applications and Examples David H. Igo and Pingyun ChenPharmaceutical Applications of Chemical Mapping and Imaging Don Clark, Mark Henson, Fred LaPlant, Slobodan Sasic and Lin ZhangTerahertz Spectroscopy for Pharmaceutical Applications Mike Claybourn, Husheng Yang, Lubomir Gradinarsky, Jonas Johansson and Staffan FolestadPart Four: ConclusionsHistory, Trends and Prognostications Peter R. Griffiths, John M. Chalmers and Don E. Pivonka