This volume captures the contents of the talks given at the Workshop on Applications of High Intensity Proton Accelerators held at Fermilab Oct 19–21, 2009. This workshop brought together experts from a variety of disciplines to explore new and profound ways proton accelerators can be used in the future. The workshop explored uses of such a proton source for producing intense muon, kaon and neutrino beams as well as using the intense protons for new forms of nuclear reactors that go by the name Accelerator Driven Sub-critical systems that promise to increase our available nuclear fuel supply by orders of magnitude while at the same time solving the nuclear waste problem. Intense proton beams can also be used to produce short-lived nuclear isotopes that are important in the medical industry.