Del i serien Springer Desktop Editions in Chemistry

Application of Transition Metal Catalysts in Organic Synthesis

Häftad, Engelska, 1999

AvL. Brandsma,S.F. Vasilevsky,H.D. Verkruijsse

1 429 kr

Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt för medlemmar vid köp för minst 249 kr.

Homogeneous catalysis is an important strategy for the synthesis of high-valued chemicals. L. Brandsma has carefully selected and checked the experimental procedures illustrating the catalytic use of copper, nickel, and palladium compounds in organic synthesis. All procedures are on a preparative scale, make economic use of solvents and catalysts, avoid toxic substances and have high yields.

Produktinformation

Utgivningsdatum1999-04-01
Mått155 x 235 x 20 mm
Vikt546 g
FormatHäftad
SpråkEngelska
SerieSpringer Desktop Editions in Chemistry
Antal sidor335
Upplaga1999
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783540655503

Tillhör följande kategorier

1 Catalysts, Ligands and Reagents.- 1.1 Catalysts.- 1.2 Ligands.- 1.3 Organometallic Reagents.- 2 Procedures for the Preparation of Halogen Compounds.- 2.1 sp-Halides.- 2.2 Aryl and Hetaryl Halides.- 2.3 Olefinic, Cycloolefinic and Allenic Halides.- 3 Cross-Coupling Between 1-Alkynes and 1-Bromoalkynes.- 3.1 Introduction.- Table 1.- 3.2 Scope and Limitations.- 3.3 Relative Reactivities of the Acetylene and the Bromoacetylene.- Table 2.- 3.4 Conditions for the Coupling.- 3.5 Choice of the Reaction Partners.- 3.6 Side Reactions.- 3.7 Experimental Part.- 4 Copper-Catalyzed Aminoalkylation of Acetylenes.- 4.1 Introduction, Scope and Mechanism.- 4.2 Experimental Part.- 5 Copper(I)-Halide-Catalyzed Oxidative Coupling of Acetylenes.- 5.1 Introduction.- 5.2 Methods, Scope and Limitations.- 5.3 About the Mechanism.- 5.4 Experimental Part.- 5.5 Summary of Experimental Conditions for Oxidative Couplings.- Table 3.- 6 Copper(I)-Halide-Catalyzed Substitution of sp2-Halogen by Alkoxide.- 6.1 Introduction.- 6.2 Scope and Limitations of the Copper-Catalyzed Nucleophilic Substitution of sp2-Halogen by Alkoxy Groups.- Table 4.- 6.3 Mechanistic Investigations.- 6.4 Reaction Conditions.- 6.5 Differences in the Reactivities of the Various sp2-Halides.- 6.6 Side Reactions.- 6.7 Applications.- 6.8 Experimental Part.- 7 Copper-Catalyzed Carbon-Carbon Bond Formation by 1,1- and 1,3-Substitution Reactions.- 7.1 Introduction.- 7.2 Displacement of Halide, Tosylate and Acetate in Saturated Compounds.- 7.3 Ring Opening of Saturated Epoxides.- 7.4 Reactions with Allylic Substrates.- 7.5 Reactions with Propargylic and Allenic Substrates.- 7.6 About the Mechanism of Copper Catalyzed Substitutions.- 7.7 Experimental Section.- Table 5.- Table 6.- 8 Nickel Catalyzed Iodo-Dechlorination and Iodo-Debromination of sp2-Halides.- 8.1 Introduction.- 8.2 Scope and Limitations.- 8.3 Mechanistic Investigations.- 8.4 Side Reactions.- 8.5 Experimental Procedures.- 8.6 Conclusions from our Investigations.- 9 Nickel- and Palladium-Catalyzed Cyanation of sp2-Halides and sp2-Triflates.- 9.1 Introduction.- 9.2 Scope and Limitations.- Table 7.- 9.3 Mechanism of the Nickel Catalyzed Cyanation.- 9.4 Methods of Performing Nickel Catalyzed Cyanations.- 9.5 Relative Reactivities of sp2-Halides.- 9.6 Side Reactions.- 9.7 Catalysis by Palladium Compounds.- 9.8 Experimental Part.- 10 Couplings of Acetylenes with sp2-Halides.- 10.1 Introduction.- 10.2 Mechanistic Considerations.- 10.3 Scope and Limitations.- Table 8.- 10.4 Relative Rates of Coupling.- 10.5 Regiochemistry and Stereochemistry.- 10.6 Synthetic Applications of the Cross-Coupling Reactions with Acetylenes.- 10.7 Practical Aspects of the Coupling Reactions.- 10.8 Experimental Section.- 11 Nickel- and Palladium-Catalyzed Cross-Coupling Reactions with Organometallic Intermediates.- 11.1 Introduction.- 11.2 Possibilities of Connecting Organic Groups by Transition Metal Catalysis.- 11.3 Catalysts and Ligands.- 11.4 Leaving Groups.- 11.5 Couplings with Organolithium Compounds.- 11.6 Couplings with Organomagnesium and Organozinc Halides.- 11.7 Cross Couplings with Organoaluminum, Organoboron and Organotin Compounds.- 11.8 Regiochemical and Stereochemical Aspects.- 11.9 Mechanism and Side Reactions.- 11.10 Practical Aspects of Transition-Metal-Catalyzed Couplings.- 11.11 Experimental Section.- Tables 9-20.- Index of Reaction Types.- Index of Experimental Procedures.- Complementary Subject Index.

Mer från samma serie

Glycoscience

Hugues Driguez, Joachim Thiem

Häftad, 1999

2 859 kr

New Enzymes for Organic Synthesis

Thomas Scheper

Häftad, 1999

719 kr

Metal Sites in Proteins and Models

H.A.O. Hill, P.J. Sadler, A.J. Thomson

Häftad, 1999

719 kr

Metal Sites in Proteins and Models

H.A.O. Hill, P.J. Sadler, A.J. Thomson

Häftad, 1999

719 kr

Stereoselective Heterocyclic Synthesis

Peter Metz

Häftad, 1999

1 429 kr

Microsystem Technology in Chemistry and Life Sciences

Andreas Manz, Holger Becker, Andreas Manz, Holger Becker

Häftad, 1999

2 139 kr

Metal Sites in Proteins and Models

H.O.A. Hill, Peter J. Sadler, A.J. Thomson

Häftad, 1999

2 139 kr

Glycoscience

Hugues Driguez, Joachim Thiem

Häftad, 1999

2 139 kr

Drug Discovery from Nature

S. Grabley, R. Thiericke

Häftad, 2000

2 209 kr

Biotransformations

K. Faber

Häftad, 2000

719 kr

Du kanske också är intresserad av

Drug Discovery from Nature

S. Grabley, R. Thiericke

Häftad, 2000

2 209 kr

Metal Sites in Proteins and Models

H.A.O. Hill, P.J. Sadler, A.J. Thomson

Häftad, 1999

719 kr

Biotransformations

K. Faber

Häftad, 2000

719 kr

Biosynthesis

F. J. Leeper, F.J. Leeper, J.C. Vederas

Häftad, 2000

719 kr

Metal Sites in Proteins and Models

H.A.O. Hill, P.J. Sadler, A.J. Thomson

Häftad, 1999

719 kr

Bioorganic Chemistry

J. Rohr

Häftad, 2000

719 kr

New Enzymes for Organic Synthesis

Thomas Scheper

Häftad, 1999

719 kr

Stereoselective Heterocyclic Synthesis

Peter Metz

Häftad, 1999

1 429 kr

Metal Sites in Proteins and Models

H.O.A. Hill, Peter J. Sadler, A.J. Thomson

Häftad, 1999

2 139 kr

Glycoscience

Hugues Driguez, Joachim Thiem

Häftad, 1999

2 139 kr

Del i serien Springer Desktop Editions in Chemistry

Application of Transition Metal Catalysts in Organic Synthesis

Häftad, Engelska, 1999

AvL. Brandsma,S.F. Vasilevsky,H.D. Verkruijsse

1 429 kr

Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt för medlemmar vid köp för minst 249 kr.

Produktinformation

Utgivningsdatum1999-04-01
Mått155 x 235 x 20 mm
Vikt546 g
FormatHäftad
SpråkEngelska
SerieSpringer Desktop Editions in Chemistry
Antal sidor335
Upplaga1999
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783540655503

Tillhör följande kategorier

1 Catalysts, Ligands and Reagents.- 1.1 Catalysts.- 1.2 Ligands.- 1.3 Organometallic Reagents.- 2 Procedures for the Preparation of Halogen Compounds.- 2.1 sp-Halides.- 2.2 Aryl and Hetaryl Halides.- 2.3 Olefinic, Cycloolefinic and Allenic Halides.- 3 Cross-Coupling Between 1-Alkynes and 1-Bromoalkynes.- 3.1 Introduction.- Table 1.- 3.2 Scope and Limitations.- 3.3 Relative Reactivities of the Acetylene and the Bromoacetylene.- Table 2.- 3.4 Conditions for the Coupling.- 3.5 Choice of the Reaction Partners.- 3.6 Side Reactions.- 3.7 Experimental Part.- 4 Copper-Catalyzed Aminoalkylation of Acetylenes.- 4.1 Introduction, Scope and Mechanism.- 4.2 Experimental Part.- 5 Copper(I)-Halide-Catalyzed Oxidative Coupling of Acetylenes.- 5.1 Introduction.- 5.2 Methods, Scope and Limitations.- 5.3 About the Mechanism.- 5.4 Experimental Part.- 5.5 Summary of Experimental Conditions for Oxidative Couplings.- Table 3.- 6 Copper(I)-Halide-Catalyzed Substitution of sp2-Halogen by Alkoxide.- 6.1 Introduction.- 6.2 Scope and Limitations of the Copper-Catalyzed Nucleophilic Substitution of sp2-Halogen by Alkoxy Groups.- Table 4.- 6.3 Mechanistic Investigations.- 6.4 Reaction Conditions.- 6.5 Differences in the Reactivities of the Various sp2-Halides.- 6.6 Side Reactions.- 6.7 Applications.- 6.8 Experimental Part.- 7 Copper-Catalyzed Carbon-Carbon Bond Formation by 1,1- and 1,3-Substitution Reactions.- 7.1 Introduction.- 7.2 Displacement of Halide, Tosylate and Acetate in Saturated Compounds.- 7.3 Ring Opening of Saturated Epoxides.- 7.4 Reactions with Allylic Substrates.- 7.5 Reactions with Propargylic and Allenic Substrates.- 7.6 About the Mechanism of Copper Catalyzed Substitutions.- 7.7 Experimental Section.- Table 5.- Table 6.- 8 Nickel Catalyzed Iodo-Dechlorination and Iodo-Debromination of sp2-Halides.- 8.1 Introduction.- 8.2 Scope and Limitations.- 8.3 Mechanistic Investigations.- 8.4 Side Reactions.- 8.5 Experimental Procedures.- 8.6 Conclusions from our Investigations.- 9 Nickel- and Palladium-Catalyzed Cyanation of sp2-Halides and sp2-Triflates.- 9.1 Introduction.- 9.2 Scope and Limitations.- Table 7.- 9.3 Mechanism of the Nickel Catalyzed Cyanation.- 9.4 Methods of Performing Nickel Catalyzed Cyanations.- 9.5 Relative Reactivities of sp2-Halides.- 9.6 Side Reactions.- 9.7 Catalysis by Palladium Compounds.- 9.8 Experimental Part.- 10 Couplings of Acetylenes with sp2-Halides.- 10.1 Introduction.- 10.2 Mechanistic Considerations.- 10.3 Scope and Limitations.- Table 8.- 10.4 Relative Rates of Coupling.- 10.5 Regiochemistry and Stereochemistry.- 10.6 Synthetic Applications of the Cross-Coupling Reactions with Acetylenes.- 10.7 Practical Aspects of the Coupling Reactions.- 10.8 Experimental Section.- 11 Nickel- and Palladium-Catalyzed Cross-Coupling Reactions with Organometallic Intermediates.- 11.1 Introduction.- 11.2 Possibilities of Connecting Organic Groups by Transition Metal Catalysis.- 11.3 Catalysts and Ligands.- 11.4 Leaving Groups.- 11.5 Couplings with Organolithium Compounds.- 11.6 Couplings with Organomagnesium and Organozinc Halides.- 11.7 Cross Couplings with Organoaluminum, Organoboron and Organotin Compounds.- 11.8 Regiochemical and Stereochemical Aspects.- 11.9 Mechanism and Side Reactions.- 11.10 Practical Aspects of Transition-Metal-Catalyzed Couplings.- 11.11 Experimental Section.- Tables 9-20.- Index of Reaction Types.- Index of Experimental Procedures.- Complementary Subject Index.