Devashish Shrivastava is a mechanical engineer with In Vivo Temperatures, LLC, Clarksville, MD, USA with a background in the assessment of in vivo tissue heating and resulting thermal damage with over 80 publications. He is also the editor of two other books, Theory and Applications of Heat Transfer in Humans and Safety and Biological Aspects in MRI.

• List of Contributors xxiPreface xxvPart A Principles 1A.1 Delivering Energy 31 Propagation of Radiofrequency and Microwaves in Tissue 5Punit Prakash and Anna Bottiglieri2 Propagation of Focused Ultrasound in Tissue 19Gregory T. Clement3 Propagation of Light in Tissue 31Do-Hyun Kim4 Mechanisms of Tissue Injury in Cryosurgery 45John G. Baust, Kimberly L. Santucci, Kristi K. Snyder, Anthony Robilotto, and John M. Baust5 Delivering Energy using Localized Hyperthermia Systems 73Hana Dobsicek Trefna, Johannes Crezee, and Petra Kok6 Role of Nanoparticles Mediated Heating in Oncology 95Gennaro BellizziA.2 Assessing Temperatures 1077 Temperature Monitoring During Thermal Treatment by Thermocouples and Thermistors: Current Status and Perspectives 109Francesca De Tommasi, Carlo Massaroni, Daniela Lo Presti, Rosario Francesco Grasso, Massimiliano Carassiti, Yuman Fong, and Emiliano Schena8 Fluorescent-Decay Temperature Probes for Biomedical Applications: Theory, Techniques, and Practical Advice 121Daryl James and Harry Vine9 Calibration and Use of Infrared Thermal Cameras in Biological Applications 135Michael L. Denton and Gary D. Noojin10 Magnetic Resonance Thermometry in Oncology: Applications in Moving Organs 149Henrik Odéen and Dennis L. Parker11 Measuring Tissue Temperature with Ultrasound 175Elyas Shaswary and Jahangir (Jahan) Tavakkoli12 Current Status and Future Potential of Thermometry Based on Computed Tomography Imaging 195Francesca De Tommasi, Carlo Massaroni, Daniela Lo Presti, Rosario Francesco Grasso, Massimiliano Carassiti, Yuman Fong, and Emiliano Schena13 A Generic Thermal Model to Predict Temperatures in Perfused Tissues 205Devashish ShrivastavaA.3 Assessing Damage 21714 Measuring Thermal Damage with Gross and Microscopic Pathology 219Sharon Thomsen15 Assessing Thermal Damage with Magnetic Resonance Imaging 251Sara L. Johnson and Allison H. Payne16 Ultrasound Imaging Techniques for the Evaluation of Thermal Damage 273Jenna Osborn17 Mathematical Models of Thermal Damage and Cell Death 289John Pearce18 A Novel Method to Indicate Onset of Photothermal Damage 307Michael L. Denton, Gary D. Noojin, and Elharith M. Ahmed19 Thermodynamic Challenges of Using Magnetic Resonance Thermometry in Measuring in vivo Temperatures and Estimating Thermal Damage in Thermal Ablation 329Devashish ShrivastavaPart B Clinical Applications 34120 Biological and Physical Aspects of Heat Therapy 343Abhijit Mandal, Ritusha Mishra, and Himanshu Mishra21 Guiding Thermal Therapy with MR 359Richard Tyc and Mark G. Torchia22 Role of Radiofrequency Ablation and Laser-Induced Thermal Therapy in the Management of Functional Neurosurgery and Brain Lesions 377Peter Konrad, Johnie Hodge, and Manish Ranjan23 Radiofrequency and Microwave Thermal Ablation in Cancer Therapy and the Role of Hydrodissection 391Arvind K. Chaturvedi24 Role of High-Intensity Focused Ultrasound for Functional Neurosurgery and for the Management of Brain Lesions 403Georgios A. Maragkos, Georgios Mantziaris, Shayan Moosa, and W. Jeffrey Elias25 Role of HIFU in Cancer Management 425Sofia Gereta, Judith Stangl-Kremser, Tenny R. Zhang, and Jim C. Hu26 Percutaneous Cryoablation: Mechanism of Action, Clinical Applications, and Outcomes 459Ahmed Farhan, Christopher R. Bailey, and Christos Georgiades27 Clinical Applications of Hyperthermia 483Himanshu Mishra, Ritusha Mishra, and Abhijit Mandal28 Thermal Damage due to a Monopole Microwave Antenna 499Marta Cavagnaro and Devashish Shrivastava29 Thermal Damage with High-Intensity Focused Ultrasound 511Devashish Shrivastava30 Thermal Damage Due to Laser 519Rahul Goyal and Devashish Shrivastava31 Thermal Damage Due to Hot and Cold Surfaces 525Devashish Shrivastava32 MRI-Induced RF Heating Considerations for Devices and Accessories that are Partially in and Partially Out of the Human Body 533Ran Guo, Md Zahidul Islam, Wolfgang Kainz, and Ji ChenReferences 542Index 545

Devashish Shrivastava is a mechanical engineer with In Vivo Temperatures, LLC, Clarksville, MD, USA with a background in the assessment of in vivo tissue heating and resulting thermal damage with over 80 publications. He is also the editor of two other books, Theory and Applications of Heat Transfer in Humans and Safety and Biological Aspects in MRI.

• List of Contributors xxiPreface xxvPart A Principles 1A.1 Delivering Energy 31 Propagation of Radiofrequency and Microwaves in Tissue 5Punit Prakash and Anna Bottiglieri2 Propagation of Focused Ultrasound in Tissue 19Gregory T. Clement3 Propagation of Light in Tissue 31Do-Hyun Kim4 Mechanisms of Tissue Injury in Cryosurgery 45John G. Baust, Kimberly L. Santucci, Kristi K. Snyder, Anthony Robilotto, and John M. Baust5 Delivering Energy using Localized Hyperthermia Systems 73Hana Dobsicek Trefna, Johannes Crezee, and Petra Kok6 Role of Nanoparticles Mediated Heating in Oncology 95Gennaro BellizziA.2 Assessing Temperatures 1077 Temperature Monitoring During Thermal Treatment by Thermocouples and Thermistors: Current Status and Perspectives 109Francesca De Tommasi, Carlo Massaroni, Daniela Lo Presti, Rosario Francesco Grasso, Massimiliano Carassiti, Yuman Fong, and Emiliano Schena8 Fluorescent-Decay Temperature Probes for Biomedical Applications: Theory, Techniques, and Practical Advice 121Daryl James and Harry Vine9 Calibration and Use of Infrared Thermal Cameras in Biological Applications 135Michael L. Denton and Gary D. Noojin10 Magnetic Resonance Thermometry in Oncology: Applications in Moving Organs 149Henrik Odéen and Dennis L. Parker11 Measuring Tissue Temperature with Ultrasound 175Elyas Shaswary and Jahangir (Jahan) Tavakkoli12 Current Status and Future Potential of Thermometry Based on Computed Tomography Imaging 195Francesca De Tommasi, Carlo Massaroni, Daniela Lo Presti, Rosario Francesco Grasso, Massimiliano Carassiti, Yuman Fong, and Emiliano Schena13 A Generic Thermal Model to Predict Temperatures in Perfused Tissues 205Devashish ShrivastavaA.3 Assessing Damage 21714 Measuring Thermal Damage with Gross and Microscopic Pathology 219Sharon Thomsen15 Assessing Thermal Damage with Magnetic Resonance Imaging 251Sara L. Johnson and Allison H. Payne16 Ultrasound Imaging Techniques for the Evaluation of Thermal Damage 273Jenna Osborn17 Mathematical Models of Thermal Damage and Cell Death 289John Pearce18 A Novel Method to Indicate Onset of Photothermal Damage 307Michael L. Denton, Gary D. Noojin, and Elharith M. Ahmed19 Thermodynamic Challenges of Using Magnetic Resonance Thermometry in Measuring in vivo Temperatures and Estimating Thermal Damage in Thermal Ablation 329Devashish ShrivastavaPart B Clinical Applications 34120 Biological and Physical Aspects of Heat Therapy 343Abhijit Mandal, Ritusha Mishra, and Himanshu Mishra21 Guiding Thermal Therapy with MR 359Richard Tyc and Mark G. Torchia22 Role of Radiofrequency Ablation and Laser-Induced Thermal Therapy in the Management of Functional Neurosurgery and Brain Lesions 377Peter Konrad, Johnie Hodge, and Manish Ranjan23 Radiofrequency and Microwave Thermal Ablation in Cancer Therapy and the Role of Hydrodissection 391Arvind K. Chaturvedi24 Role of High-Intensity Focused Ultrasound for Functional Neurosurgery and for the Management of Brain Lesions 403Georgios A. Maragkos, Georgios Mantziaris, Shayan Moosa, and W. Jeffrey Elias25 Role of HIFU in Cancer Management 425Sofia Gereta, Judith Stangl-Kremser, Tenny R. Zhang, and Jim C. Hu26 Percutaneous Cryoablation: Mechanism of Action, Clinical Applications, and Outcomes 459Ahmed Farhan, Christopher R. Bailey, and Christos Georgiades27 Clinical Applications of Hyperthermia 483Himanshu Mishra, Ritusha Mishra, and Abhijit Mandal28 Thermal Damage due to a Monopole Microwave Antenna 499Marta Cavagnaro and Devashish Shrivastava29 Thermal Damage with High-Intensity Focused Ultrasound 511Devashish Shrivastava30 Thermal Damage Due to Laser 519Rahul Goyal and Devashish Shrivastava31 Thermal Damage Due to Hot and Cold Surfaces 525Devashish Shrivastava32 MRI-Induced RF Heating Considerations for Devices and Accessories that are Partially in and Partially Out of the Human Body 533Ran Guo, Md Zahidul Islam, Wolfgang Kainz, and Ji ChenReferences 542Index 545

Devashish Shrivastava is a mechanical engineer with In Vivo Temperatures, LLC, Clarksville, MD, USA with a background in the assessment of in vivo tissue heating and resulting thermal damage with over 80 publications. He is also the editor of two other books, Theory and Applications of Heat Transfer in Humans and Safety and Biological Aspects in MRI.

• List of Contributors xxiPreface xxvPart A Principles 1A.1 Delivering Energy 31 Propagation of Radiofrequency and Microwaves in Tissue 5Punit Prakash and Anna Bottiglieri2 Propagation of Focused Ultrasound in Tissue 19Gregory T. Clement3 Propagation of Light in Tissue 31Do-Hyun Kim4 Mechanisms of Tissue Injury in Cryosurgery 45John G. Baust, Kimberly L. Santucci, Kristi K. Snyder, Anthony Robilotto, and John M. Baust5 Delivering Energy using Localized Hyperthermia Systems 73Hana Dobsicek Trefna, Johannes Crezee, and Petra Kok6 Role of Nanoparticles Mediated Heating in Oncology 95Gennaro BellizziA.2 Assessing Temperatures 1077 Temperature Monitoring During Thermal Treatment by Thermocouples and Thermistors: Current Status and Perspectives 109Francesca De Tommasi, Carlo Massaroni, Daniela Lo Presti, Rosario Francesco Grasso, Massimiliano Carassiti, Yuman Fong, and Emiliano Schena8 Fluorescent-Decay Temperature Probes for Biomedical Applications: Theory, Techniques, and Practical Advice 121Daryl James and Harry Vine9 Calibration and Use of Infrared Thermal Cameras in Biological Applications 135Michael L. Denton and Gary D. Noojin10 Magnetic Resonance Thermometry in Oncology: Applications in Moving Organs 149Henrik Odéen and Dennis L. Parker11 Measuring Tissue Temperature with Ultrasound 175Elyas Shaswary and Jahangir (Jahan) Tavakkoli12 Current Status and Future Potential of Thermometry Based on Computed Tomography Imaging 195Francesca De Tommasi, Carlo Massaroni, Daniela Lo Presti, Rosario Francesco Grasso, Massimiliano Carassiti, Yuman Fong, and Emiliano Schena13 A Generic Thermal Model to Predict Temperatures in Perfused Tissues 205Devashish ShrivastavaA.3 Assessing Damage 21714 Measuring Thermal Damage with Gross and Microscopic Pathology 219Sharon Thomsen15 Assessing Thermal Damage with Magnetic Resonance Imaging 251Sara L. Johnson and Allison H. Payne16 Ultrasound Imaging Techniques for the Evaluation of Thermal Damage 273Jenna Osborn17 Mathematical Models of Thermal Damage and Cell Death 289John Pearce18 A Novel Method to Indicate Onset of Photothermal Damage 307Michael L. Denton, Gary D. Noojin, and Elharith M. Ahmed19 Thermodynamic Challenges of Using Magnetic Resonance Thermometry in Measuring in vivo Temperatures and Estimating Thermal Damage in Thermal Ablation 329Devashish ShrivastavaPart B Clinical Applications 34120 Biological and Physical Aspects of Heat Therapy 343Abhijit Mandal, Ritusha Mishra, and Himanshu Mishra21 Guiding Thermal Therapy with MR 359Richard Tyc and Mark G. Torchia22 Role of Radiofrequency Ablation and Laser-Induced Thermal Therapy in the Management of Functional Neurosurgery and Brain Lesions 377Peter Konrad, Johnie Hodge, and Manish Ranjan23 Radiofrequency and Microwave Thermal Ablation in Cancer Therapy and the Role of Hydrodissection 391Arvind K. Chaturvedi24 Role of High-Intensity Focused Ultrasound for Functional Neurosurgery and for the Management of Brain Lesions 403Georgios A. Maragkos, Georgios Mantziaris, Shayan Moosa, and W. Jeffrey Elias25 Role of HIFU in Cancer Management 425Sofia Gereta, Judith Stangl-Kremser, Tenny R. Zhang, and Jim C. Hu26 Percutaneous Cryoablation: Mechanism of Action, Clinical Applications, and Outcomes 459Ahmed Farhan, Christopher R. Bailey, and Christos Georgiades27 Clinical Applications of Hyperthermia 483Himanshu Mishra, Ritusha Mishra, and Abhijit Mandal28 Thermal Damage due to a Monopole Microwave Antenna 499Marta Cavagnaro and Devashish Shrivastava29 Thermal Damage with High-Intensity Focused Ultrasound 511Devashish Shrivastava30 Thermal Damage Due to Laser 519Rahul Goyal and Devashish Shrivastava31 Thermal Damage Due to Hot and Cold Surfaces 525Devashish Shrivastava32 MRI-Induced RF Heating Considerations for Devices and Accessories that are Partially in and Partially Out of the Human Body 533Ran Guo, Md Zahidul Islam, Wolfgang Kainz, and Ji ChenReferences 542Index 545