Application of DNA-based Nanomaterials in Tissue Regeneration

Yunfeng Lin is Vice Dean of West China College of Stomatology, and Vice-director of State Key Laboratory of Oral Diseases. His main research focuses on DNA Nanomaterial, Stem Cell Biology and Tissue Regeneration. He’s published over 234 SCI papers including Nature Protocols, Advanced Materials, Materials Today, Nano Today, Advanced Functional Materials, ACS Nano, Nano Letters, Nano Micro Letters, Journal of Dental Research et al. Dr. Lin has edit 8 English books. He’s received many awards, including IADR Distinguished Scientist Isaac Schour Memorial Award, Yangtze River Scholar Distinguished Professor, National High-level personnel of special support program of China, and Young Scientific and Technological Innovation Leader of China, to name a few. Additionally, he is the Executive Editor in Chief of Bone Research and Cell Proliferation, Editor of International Journal of Dental Research, Journal of Dental Research.Taoran Tian is an Associate Professor in the Department of Oral Implantology at West China Hospital of Stomatology and a Master's supervisor. He pursued joint doctoral training at Yale University in the United States. Dr. Tian was selected for the Sichuan Provincial "Health and Wellness Talent Plan" as a young and middle-aged key talent. He has been awarded the Chinese Medical Science and Technology Award for Young Scientists and serves as a youth member of the Sichuan Medical Association's Stomatology Committee.Songhang Li graduated from West China School of Stomatology, Sichuan University in 2023, and has been engaged in the platform construction of nucleic acid drug delivery system based on tetrahedral framework nucleic acid since 2017. During this period, he has published 12 SCI papers as the first author, including Nature Protocols, Advanced Materials, Materials Today, Small, and Molecular Therapy. He has co-authored several English monographs. Three Chinese patents related to the content have been granted. He is currently the principal investigator of five projects, including Postdoctoral Science Foundation of China, Postdoctoral Fellowship Program of CPSF and Miaozi Project in Science andTechnology Innovation Program of Sichuan Province. His research areas include DNA nanotechnology and tissue regeneration. Yuanlin Tang, assistant researcher of Sichuan University, is engaged in nucleic acid nanomaterials research in the State Key Laboratory of Oral Disease Prevention and Treatment. She is the deputy secretary of the General of Medical and Media mutual Promotion Branch of Sichuan Medical Science and Technology Innovation Research Association, and the member of the Oral Materials Professional Committee of Sichuan Stomatological Society. Her research interests include nucleic acid nanomaterials, health policy & management, medical media，etc.

• Part I: The Mechanism of Nucleic Acid Nanostructure in Tissue Regeneration1. Nucleic Acid Nanostructures 1.1 Two-Dimensional Nucleic Acid Nanostructures2. Cellular Uptake of Nucleic Acid Nanostructures3. Intracellular Fate of Framework Nucleic Acids4. In Vivo Delivery of Nucleic Acid Nanomaterials (In Vivo Distribution and Circulation Clearance)5. The Mechanism of Action of Nucleic Acid NanomaterialsPart II: DNA Nanomaterial-Based Cell Surface Engineering for Tissue Regeneration6. Introduction7. Cell Surface Engineering Modification Method Based on DNA Nanomaterials8. Application of Cell Surface Engineering Methods Based on DNA Nanomaterials in Tissue Regeneration9. Challenges and Prospects of DNA Nanomaterials in Cell Surface EngineeringPart III: Supramolecular DNA Hydrogels for Tissue Regeneration: Current Application and Future Development10. Introduction11. The Advantages of DNA Hydrogel in Tissue Regeneration12. The Design and Strategy of DNA Hydrogel13. The Supramolecular DNA Hydrogels for Different Tissue Regeneration Fields14. Prospects and ChallengesPart IV: DNA Nanomaterial-Based Drug Delivery System: Application in Tissue Regeneration15. Drug Loading Strategy16. Application of Delivery Modification Based on DNA Nanomaterials in Tissue Regeneration