Antiseizure Medication Interactions

Philip Patsalos is an Emeritus Professor of Clinical Pharmacology at University College London's Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy, London UK. His clinical and research interests relate to the therapeutics of epilepsy and include: new drug treatments and strategies, new drug development (Phase II and III trials) and formulations, pharmacokinetic profiling and drug interactions. He has in excess of 230 publications (books, book chapters and peer reviewed papers) and has served on various International League Against Epilepsy (ILAE) committees (including the Commission on Therapeutic Strategies, the Commission on Generics, the Sub-Commission on Polytherapy and Drug Interaction and the Sub-Commission on Therapeutic Drug Monitoring) and International Association of Therapeutic Drug Monitoring and Clinical Toxicology committees (including the Clinical Pharmacokinetics Committee and the Impact of Therapeutic Drug Monitoring on Pharmacoeconomics Committee). He was recently awarded the 2016 Excellence in Epilepsy Lifetime Achievement Award by the British Branch ILAE for his contribution to epilepsy care and research.

• Section 1 – Introduction.- Section 2 – Drug Interactions Between AEDs.- Acetazolamide.- Cannabidiol.-  Carbamazepine.- Clobazam.- Clonazepam.- Ethosuximide.- Eslicarbazepine acetate.- Felbamate.- Fenfluramine.- Gabapentin.- Lacosamide.- Lamotrigine.- Levetiraceta.- Methsuximide.- Oxcarbazepine.- Perampanel.- Phenobarbital.- Phenytoin.- Piracetam.- Pregabalin.- Primidone.- Rufinamide.- Stiripentol.- Tiagabine.- Topiramate.- Valproic Acid.- Vigabatrin.- Zonisamide.- Section 3 – Drug Interactions between AEDs and non-AED drugs: Interactions Affecting AEDs.- Acetazolamide.- Cannabidiol.- Carbamazepine.- Clobazam.- Clonazepam.- Ethosuximide.- Eslicarbazepine acetate.- Felbamate.- Fenfluramine.- Gabapentin.- Lacosamide.- Lamotrigine.- Levetiracetam.- Methsuximide.- Oxcarbazepine.- Perampanel.- Phenobarbital.- Phenytoin.- Piracetam.- Pregabalin.- Primidone.- Rufinamide.- Stiripentol.- Tiagabine.- Topiramate.- Valproic Acid.- Vigabatrin.- Zonisamide.- Section 4– Drug Interactions between AEDs and non-AED drugs: Interactions Affected by AEDS.- Analgesics.- Antimicrobials.- Antineoplastic agents.- Antiulcer drugs.- Cardiovascular drugs.- Immunosuppressants.- Neuromuscular Blocking Agents.- Psychotropic Drugs.- Steroids.- Miscellanea.