Antimicrobial Therapy in Veterinary Medicine

The editors Patricia M. Dowling, DVM, MSc, DACVIM, DACVCP, is Professor of Veterinary Clinical Pharmacology at the Western College of Veterinary Medicine, University of Saskatchewan in Saskatoon, Saskatchewan, Canada. John F. Prescott, MA, VetMB, PhD, FCAHS, is University Professor Emeritus at the Ontario Veterinary College, University of Guelph in Guelph, Ontario, Canada. Keith E. Baptiste, BVMS, MSc, PhD, MRCVS, DACVIM, DECEIM, is Senior Veterinary Consultant in the Department of Veterinary Medicine at Danish Medicines Agency in Copenhagen, Denmark.

• Contributors ixPreface xiiiAcknowledgments xvImportant Notice xviiList of Abbreviations xixSection I General Principles of Antimicrobial Therapy 11 Antimicrobial Drug Action and Interaction: An Introduction 3John F. Prescott2 Antimicrobial Susceptibility Testing Methods and Interpretation of Results 13Joseph E. Rubin and Peter Damborg3 Antimicrobial Resistance and Its Epidemiology 29Marisa Haenni and Patrick Boerlin4 Pharmacokinetics of Antimicrobials 51Patricia M. Dowling5 Pharmacodynamics of Antimicrobials 81Andrew P. Woodward and Ted Whittem Copyrighted Material6 Principles of Antimicrobial Drug Selection and Use 109J. Scott Weese and Patricia M. DowlingSection II Classes of Antimicrobial Agents 1197 Beta-lactam Antibiotics: Penam Penicillins 121Laura Y. Hardefeldt and John F. Prescott8 Beta-lactam Antibiotics: Cephalosporins 143Laura Y. Hardefeldt and John F. Prescott9 Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams 169John F. Prescott and Laura Y. Hardefeldt10 Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin 187Patricia M. Dowling11 Lincosamides, Pleuromutilins, and Streptogramins 203Grazieli Maboni and Leticia Trevisan Gressler12 Macrolides, Azalides, and Ketolides 223John F. Prescott and Keith E. Baptiste13 Aminoglycosides and Aminocyclitols 249Patricia M. Dowling14 Tetracyclines 273Ronan J. J. Chapuis and Joe S. Smith15 Chloramphenicol, Thiamphenicol, and Florfenicol 291Patricia M. Dowling and Hélène Lardé16 Sulfonamides, Diaminopyrimidines, and Their Combinations 305Jennifer M. Reinhart and John F. Prescott17 Fluoroquinolones 325Patricia M. Dowling18 Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others 345Patricia M. Dowling and Keith E. Baptiste19 Antifungal Chemotherapy 371Keith E. BaptisteSection III Antimicrobial Stewardship 40120 General Concepts in Antimicrobial Stewardship 403Laura Y. Hardefeldt, J. Scott Weese, and Stephen W. Page21 Global Aspects of One Health Antimicrobial Stewardship 425Jeffrey T. LeJeune, Mark E. Caudell, Suzanne N. Eckford, and Stephen W. Page22 Antimicrobial Stewardship in Companion Animals 445Peter Damborg, J. Scott Weese, and John F. Prescott23 Antimicrobial Stewardship in Food-producing Animals 459David C. Speksnijder, Stephen W. Page, Jaap A. Wagenaar, and John F. Prescott24 Antimicrobial Prophylaxis, Metaphylaxis, and the Treatment of Immunocompromised Patients 487Diego E. Gomez and J. Scott Weese25 Regulation of Antimicrobial Use in Animals 513Alan Chicoine and Keith E. Baptiste26 Antimicrobial Drug Residues in Foods of Animal Origin 527Joe S. Smith and Patricia M. DowlingSection IV Antimicrobial Therapy in Selected Animal Species 54527 Antimicrobial Drug Use in Horses 547Keith E. Baptiste28 Antimicrobial Therapy in Dogs and Cats 577Jane E. Sykes and Peter Damborg29 Antimicrobial Therapy in Beef Cattle 611Michael D. Apley, Brian V. Lubbers, and Nora D. Schrag30 Antimicrobial Therapy in Dairy Cattle 635Sarah Wagner and Sarah Depenbrock31 Antimicrobial Therapy in Sheep and Goats 655Joe S. Smith and Amanda J. Kreuder32 Antimicrobial Therapy in New World Camelids 671Joe S. Smith33 Antimicrobial Therapy in Swine 685Ken Steen Pedersen34 Antimicrobial Therapy in Poultry 697Jenny A. Nicholds, David French, Daniel Parker, and Peter O’Kane35 Antimicrobial Therapy in Companion Birds 721Marike Visser36 Antimicrobial Therapy in Rabbits, Rodents, and Ferrets 735Colette L. Wheler and Patricia M. Dowling37 Antimicrobial Therapy in Reptiles 767J. Scott Weese38 Antimicrobial Therapy in Zoo and Wildlife Species 791Ellen Wiedner and Robert P. Hunter39 Antimicrobial Therapy in Aquaculture 803Patrick Whittaker, Timothy S. Kniffen, and Simon Otto40 Antimicrobial Therapy in Honey Bees 819Elemir Simko, Sarah Wood, and Ivanna V. KoziiIndex 831

"The 6th edition of this textbook, first published in 1998, has several major additions that provide significant improvements to the usefulness of this text....the text is well-organized and very well-written with an impressive list of authors with strong credentials. The new edition provides some important and appreciated updates and will certainly be a welcome addition to the libraries of a wide variety of readers including students, veterinarians, educators, and regulators."Reviewed by John R. Campbell in Canadian Veterinary Journal, Volume 66, July 2025