Antimicrobial Pharmacodynamics in Theory and Clinical Practice

Nightingale, Charles H.; Ambrose, Paul G.; Drusano, George L.; Murakawa, Takeo

• Introduction. Pharmacodynamics of Antimicrobials: General Concepts and Applications Impact of Pharmacodynamics on Breakpoint Selection for Susceptibility Testing. Non-Clinical Models of Infection. In Vitro Antibiotic Pharmacokinetic Models. Animal Models of Infection for the Study of Antibiotic Pharmacodynamics. The Predictive Value of Laboratory Tests for Efficacy of Antibiotic Combination Therapy. Antibacterial Agents. Beta-Lactam Antibiotics. Aminoglycoside Antibiotics. Quinolones. Glycopeptides. Macrolide, Azalide and Ketolides. Metronidazole, and Clindamycin. Streptogramins, Oxazolididones. Tetracyclines. Antiviral Agents. Nucleoside Reverse Transcriptase Inhibitors. Protease Inhibitors. Hepatitis B and C. Antifungal Agents. Amphotericin. Azoles. Gulcan Synthase Inhibitors. Antimalarial Agents. Anti-Malarials. Pharmacodynamics in Drug Development. Human Pharmacodynamics of Anti-Infectives: Determination from Clinical Trial Data. Pharmacodynamics in Global Bridging Studies. Toxicodynamics. Pharmacodynamics and Resistance. Antibacterial Resistance. Application of PK-PD to Clinical and Formulary Decisions. Basic Pharmacoeconomics. Utilizing Pharmacodynamics and Pharmacoeconomics in Clinical and Formulary Decision Making.