Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine.

• Part I Neurotoxicity of the Anesthetics for Developing Brain.- Chapter 1 Laboratory Findings: To What Degree Can We Extrapolate the Animal Data to the Bedside?.- Chapter 2 Clinical Findings Including Prevention and Treatment.- Chapter 3 Implications for Pediatric Anesthesia.- Part II Postoperative Delirium and Cognitive Dysfunction.- Chapter 4 Present Clinical Status of Postoperative Delirium (POD).- Chapter 5 Present Clinical Status of Postoperative Cognitive Dysfunction in Cardiovascular Surgery.- Chapter 6 Present Clinical Status of Postoperative Cognitive Dysfunction Following Non-Cardiac Surgery.- Chapter 7 Diagnosis of POD and POCD.- Chapter 8 Prevention and Treatment of Postoperative Delirium and Postoperative Cognitive Dysfunction.- Chapter 9 Mechanism of POD and POCD-Effect of Anesthetics.- Chapter 10 Mechanism of POCD and POCD-Effect of Other Than Anesthetics.

“Anesthesia and Neurotoxicity – a unique synthesis of basic science and clinical research – is concerned with the neurotoxic effects of anesthetic drugs. It is a concise, up-to-date review of the literature and could be a useful reference for anesthesia care providers who may have to allay their patients’ concerns about the potential harmful effects of general anesthesia.” (O. Predescu, Canadian Journal of Anesthesia/Journal canadien d'anesthésie, Vol. 65 (10), October, 2018)“This book covers a wide range of anesthesia and neurotoxicity topics: from developmental neurotoxicity to POD and POCD, from animal studies to clinical evidence, from diagnosis of neurotoxicity to prevention and treatment approaches, and from symptoms to the underlying mechanisms.” (Xiaowen Bai, Anesthesia & Analgesia, Vol. 127 (2), August, 2018)

Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine.

• Part I Neurotoxicity of the Anesthetics for Developing Brain.- Chapter 1 Laboratory Findings: To What Degree Can We Extrapolate the Animal Data to the Bedside?.- Chapter 2 Clinical Findings Including Prevention and Treatment.- Chapter 3 Implications for Pediatric Anesthesia.- Part II Postoperative Delirium and Cognitive Dysfunction.- Chapter 4 Present Clinical Status of Postoperative Delirium (POD).- Chapter 5 Present Clinical Status of Postoperative Cognitive Dysfunction in Cardiovascular Surgery.- Chapter 6 Present Clinical Status of Postoperative Cognitive Dysfunction Following Non-Cardiac Surgery.- Chapter 7 Diagnosis of POD and POCD.- Chapter 8 Prevention and Treatment of Postoperative Delirium and Postoperative Cognitive Dysfunction.- Chapter 9 Mechanism of POD and POCD-Effect of Anesthetics.- Chapter 10 Mechanism of POCD and POCD-Effect of Other Than Anesthetics.

“Anesthesia and Neurotoxicity – a unique synthesis of basic science and clinical research – is concerned with the neurotoxic effects of anesthetic drugs. It is a concise, up-to-date review of the literature and could be a useful reference for anesthesia care providers who may have to allay their patients’ concerns about the potential harmful effects of general anesthesia.” (O. Predescu, Canadian Journal of Anesthesia/Journal canadien d'anesthésie, Vol. 65 (10), October, 2018)“This book covers a wide range of anesthesia and neurotoxicity topics: from developmental neurotoxicity to POD and POCD, from animal studies to clinical evidence, from diagnosis of neurotoxicity to prevention and treatment approaches, and from symptoms to the underlying mechanisms.” (Xiaowen Bai, Anesthesia & Analgesia, Vol. 127 (2), August, 2018)

Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine.

• Part I Neurotoxicity of the Anesthetics for Developing Brain.- Chapter 1 Laboratory Findings: To What Degree Can We Extrapolate the Animal Data to the Bedside?.- Chapter 2 Clinical Findings Including Prevention and Treatment.- Chapter 3 Implications for Pediatric Anesthesia.- Part II Postoperative Delirium and Cognitive Dysfunction.- Chapter 4 Present Clinical Status of Postoperative Delirium (POD).- Chapter 5 Present Clinical Status of Postoperative Cognitive Dysfunction in Cardiovascular Surgery.- Chapter 6 Present Clinical Status of Postoperative Cognitive Dysfunction Following Non-Cardiac Surgery.- Chapter 7 Diagnosis of POD and POCD.- Chapter 8 Prevention and Treatment of Postoperative Delirium and Postoperative Cognitive Dysfunction.- Chapter 9 Mechanism of POD and POCD-Effect of Anesthetics.- Chapter 10 Mechanism of POCD and POCD-Effect of Other Than Anesthetics.

“Anesthesia and Neurotoxicity – a unique synthesis of basic science and clinical research – is concerned with the neurotoxic effects of anesthetic drugs. It is a concise, up-to-date review of the literature and could be a useful reference for anesthesia care providers who may have to allay their patients’ concerns about the potential harmful effects of general anesthesia.” (O. Predescu, Canadian Journal of Anesthesia/Journal canadien d'anesthésie, Vol. 65 (10), October, 2018)“This book covers a wide range of anesthesia and neurotoxicity topics: from developmental neurotoxicity to POD and POCD, from animal studies to clinical evidence, from diagnosis of neurotoxicity to prevention and treatment approaches, and from symptoms to the underlying mechanisms.” (Xiaowen Bai, Anesthesia & Analgesia, Vol. 127 (2), August, 2018)