Hiroshi Mitsumoto, Serge Przedborski, Paul H. Gordon

• Overview of Clinical ALS. History. Epidemiology. Pathology. Clinical Features: Motor System. Clinical Features: Dementia and Cognitive Deficits. Familial ALS and Genetic Approaches to ALS. Electrophysiology and Other Objective Markers. Classification, Diagnosis and Presentation of Diagnosis of ALS. Natural History. Translational Research in ALS: Mechanisms behind therapy. Motor Neuron: The origin, definition and function. Neurodegeneration. Excitotoxicity. Oxidative Stress. Neuroinflammation.Apoptosis. Cytoskeleton. Mitochondria. Environmental Neurotoxicity. Genetic Causes and Predisposition. Protein Aggregate Disease. Proteiomic and Metabolomic Approach.Infections and Autoimmunity. Gene Transfer Technology. High Through-put Technology. Animal Models. Restoration-Practical Approach. Clinical Trial Methodology. ALS Therapy: Care and Management. Multidisciplinary Approach: Ideal Care Centers and World Perspective. Impact of National ALS Care Database and Practice Parameters. Symptomatic Pharmacotherapy: Bulbar and Constitutional Symptoms. Pharmacotherapy: In clinical trials. Physical Rehabilitation. Speech Therapy and Augmentative Communication/Assistive Technology. Nutritional treatment: Theoretical and Practical issues. Respiratory care: Basic and Practical. Psychosocial care: Patient and Caregiver Support. Palliative Care. Palliative Care: Family Perspective. Decision Making for End of Life. National ALS Study Group: Future of ALS Clinical Research