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The development of calcium antagonists has recently been described as representing "one of the major advances in cardiovascular therapeutics of the latter half of the twentieth century". Although the development of these drugs started in the mid-nineteen sixties it is only recently that their real potential has begun to be appreciated. The information that is supplied in this book is meant to arouse the readers' interest in the long-acting calcium antagonist - amlodipine by outlining the properties of this compound and attempting to evaluate its merits relative to other calcium antagonists. The book is of special interest for clinicians who prescribe this drug and are aiming at a satifactory management of their patients.
Produktinformation
Utgivningsdatum1993-09-03
Mått155 x 235 x 17 mm
Vikt452 g
FormatHäftad
SpråkEngelska
Antal sidor277
Upplaga1993
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
1. The Calcium Antagonists: Are Different Drugs Needed?.- 2. Calcium and Its Relevance to Biological Systems.- 3. Cell Membrane Transport.- 4. The Voltage-Activated, Calcium Antagonist-Sensitive Calcium Channels: Their Structure, Composition and Calcium Antagonist Binding Sites.- 5. The Chemistry of the Calcium Antagonists.- 6. Amlodipine — A Long-Acting Second Generation Calcium Antagonist With an Unusual Binding Profile.- 7. The Pharmacokinetic Properties of Amlodipine.- 8. The Vascular Selectivity of Amlodipine.- 9. Conditions Which Affect the Pharmacokinetic Profile of Amlodipine.- 10. Calcium Antagonists and the Kidney.- 11. Calcium Antagonism and the Ischaemic Heart: Is Calcium Antagonism Relevant?.- 12. Calcium Antagonists and the Stunned Heart — Are Vascular Selective Antagonists Protective?.- 13. Amlodipine and the Hibernating Myocardium: Could it be Beneficial?.- 14. Calcium Antagonists and the Treatment of Hypertension.- 15. The Antiatherogenic Potential of the Calcium Antagonists, Including Amlodipine.- 16. Amlodipine and the Coronary Circulation: Is it a Useful Antianginal Agent?.- 17. Calcium Antagonists and Heart Failure.- 18. The Side-Effects of Calcium Antagonist Therapy. Is Amlodipine Different?.- 19. The Future of Calcium Antagonism.- References.