Aminoglycoside Antibiotics

DEV P. ARYA is an Associate Professor of Chemistry and Director of the Laboratory of Medicinal Chemistry at Clemson University. He is a member of the ACS, and currently serves as the Program Chair of the Division of Carbohydrate Chemistry. His research interests lie in the development of nucleic acid targeted drugs.

• Preface viiContributors ix1. In the Beginning There Was Streptomycin 1Julian Davies2. The Biochemistry and Genetics of Aminoglycoside Producers 15Wolfgang Piepersberg, Khaled M. Aboshanab, Heike Schmidt-Beißner, and Udo F. Wehmeier3. Mechanisms of Aminoglycoside Antibiotic Resistance 119Tushar Shakya and Gerard D. Wright4. Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside Antibiotics 141Jinhua Wang and Cheng-Wei Tom Chang5. NMR Structural Studies of Aminoglycoside: RNA Interaction 181R. Andrew Marshall and Joseph D. Puglisi6. Structural Comparisons Between Prokaryotic and Eukaryotic Ribosomal Decoding a Sites Free and Complexed with Aminoglycosides 209Jiro Kondo and Eric Westhof7. Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial Ribosome 225Dale Kling, Christine Chow, and Shahriar Mobashery8. Metalloaminoglycosides: Chemistry and Biological Relevance 235Nikhil Gokhale, Anjali Patwardhan, and J. A. Cowan9. Adverse Effects of Aminoglycoside Therapy 255Andra E. Talaska and Jochen Schacht10. Targeting HIV-1 RNA with Aminoglycoside Antibiotics and Their Derivatives 267Lev Elson-Schwab and Yitzhak Tor11. Novel Targets for Aminoglycosides 289Dev P. Arya, Nicholas Shaw, and Hongjuan XiIndex 315

"This is a 'must-have' text for anyone involved in AGA teaching or research. No better comprehensive treatise exists…" (Journal of Medicinal Chemistry, October 18, 2007)  "There is little doubt that this volume will be a tremendous resource for any investigator interested in the biochemistry of aminoglycosides." (Journal of the American Chemical Society, September 26, 2007)