Alzheimer’s Disease

Methods and Protocols

Inbunden, Engelska, 2022

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This volume explores the latest techniques used to study the human brain towards understanding Alzheimer’s Disease and related neurodegenerative disorders. Part Three details nucleic acid analyses including transcriptomic and somatic genomic changes, and Part Four discusses lipid analyses via mass spectrometry.

Produktinformation

Utgivningsdatum2022-11-19
Mått178 x 254 x 25 mm
Vikt867 g
FormatInbunden
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor340
FörlagSpringer-Verlag New York Inc.
ISBN9781071626542

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Biovetenskap inom Naturvetenskap och teknik

Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain Tissue.- Extraction and Purification of Single Nuclei from Frozen Human Brain Tissue.- Isolation of Human Microglia from Neuropathologically Diagnosed Cases in the Single-Cell Era.- Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electron Microscopy Images.- Three-Dimensional Imaging of Fibrinogen and Neurovascular Alterations in Alzheimer’s Disease.- Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer’s Disease.- Modeling Alzheimer’s Disease using Human Brain Organoids.- 3D Biohybrid StarPEG-Heparin Hydrogel Cultures for Modeling Human Neuronal Development and Alzheimer’s Disease Pathology.- Computational Approaches to Assess Abnormal Metabolism in Alzheimer’s Disease Using Transcriptomics.- FISHing for Chromosome Instability and Aneuploidy in the Alzheimer’s Disease Brain.- Somatic CNV Detection by Single-Cell Whole-Genome Sequencing in Post-Mortem Human Brain.- Mass Spectrometry Analysis of the Human Brain Sphingolipidome.- Mass Spectrometry for the Advancement of Lipid Analysis in Alzheimer’s Research.- The Use of Affinity Purification-Mass Spectrometry to identify Phosphorylates Tau Interactors in Alzheimer’s Disease.- In Vitro Amplification of Pathogenic Tau Seeds from Neurodegenerative Disease Patient Brains.- Aβ and Tau Prions Causing Alzheimer’s Disease.