"In a real sense, this book answers the question, 'What is the cutting edge of research connecting computer science with the biological sciences?' ... [I]ts breadth of content is impressive, and its combination of advanced tutorials with ambitious new proposals is scientifically exciting. ... [The book] will best serve TCS researchers who are looking for new questions to ask, and for new areas in which to apply their skills." (Aaron Sterling, The Book Review Column 43-3, 2012)