Alcohol Use Disorders and the Lung

• A Brief History of Alcohol Use and Abuse in Human History.- Overview of the Evolving Recognition of the Health Effects of Excessive Alcohol Use Over the Past Two Centuries Including the Classic Citations.- Current Definitions of Alcohol Use Disorders and the Use of Validated Questionnaires in Clinical Practice and Research.- The Epidemiology of Alcohol Abuse and Pneumonia.- The Epidemiology of Alcohol and Acute Respiratory Distress Syndrome.- Alcohol, the Upper Airway, and Mucociliary Dysfunction in the Conducting Airways.- Alcohol and the Alveolar Macrophage.- Alcohol and the Alveolar Epithelium.- Alcohol-Mediated Oxidative Stress in the Airway: The Unique Role of Thiol Depletion.- Alcohol and the Adaptive Immune Response in the Airway: Dendritic Cell and Lymphocyte Impairments.- Alcohol Impairment of Granulocyte Function During Lung Infection.- Disruption in the Dynamic Balance Between Transforming Growth Factor-β and Granulocyte/Macrophage Colony-stimulating Factor Signaling within the Alveolar Space of the Alcoholic Lung: Impact on Epithelial and Macrophage Function.- Alcohol-mediated Zinc Deficiency within the Alveolar Space: A Potential Fundamental Mechanism Underlying Oxidative Stress and Cellular Dysfunction in the Alcoholic Lung.- The Impact of Alcohol Abuse on Multiple Organ Dysfunction in the Surgical Patient.- Alcohol and HIV: Experimental and Clinical Evidence of Combined Impact on the Lung.- Maternal Alcohol Use and the Neonate.

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