Alcohol Abuse and Liver Disease

James Neuberger MD, is a Consultant Hepatologist and Professor of Hepatology, Queen Elizabeth Hospital, Birmingham and Associate Medical Director at NHS Blood and Transplant. He is Editor-in-Chief of LWW's Transplantation, the journal of the Transplantation Society, and on the board of several liver and transplant journals. He has 295 articles listed on PubMed.Andrea DiMartini is Associate Professor of Psychiatry and Surgery in the Department of Psychiatry in the University of Pittsburgh. She has over 20 years' clinical and research experience of working with transplant surgeons and physicians in the Starzl Transplantation Institute. She was awarded the 2011 Research Award by the Academy of Psychosomatic Medicine and has focused on the natural history and management of patients with alcohol and substance abuse.

• List of Contributors viiPreface xi1 Epidemiology of alcohol use 1Ian Gilmore and William Gilmore2 Epidemiology of alcohol]related liver disease 11Ed Britton and Martin Lombard3 Alcoholism: diagnosis and natural history in the context of medical disease 23Thomas P. Beresford Narin Wongngamnit and Benjamin A. Temple4 Alcohol and other substance misuse 35John B. Saunders5 Risk factors for alcohol]related liver disease 47Stuart Kendrick and Chris Day6 Mechanisms of alcohol toxicity 55Guruprasad P. Aithal and Jane I. Grove7 Extrahepatic manifestations of alcohol excess 65Karl]Heinz Schulz Sandra van Eckert and Jens Reimer8 Patterns of alcohol]associated liver damage 79Peter Hayes and Michael Williams9 Cofactors and alcohol]related liver disease 87John G. O’Grady10 Impact of alcohol and liver disease on prescribing 91Richard Parker and Amanda Smith11 Psychiatric examination of liver transplant patients with alcohol use disorders 99Robert M. Weinrieb and Omair Abbasi12 Abnormal liver tests in the context of alcohol excess 109James Ferguson13 Biochemical determination of alcohol consumption 113Friedrich Martin Wurst Natasha Thon Wolfgang Weinmann Michel Yegles Jessica Wong and Ulrich W. Preuss14 The role of histology 123Desley A.H. Neil15 General assessment and management 135Patrizia Burra and Giacomo Germani16 Brief alcohol interventions 147Stephanie Scott and Eileen Kaner17 Alcohol withdrawal syndrome: diagnosis and treatment 155Julie Taub and Thomas P. Beresford18 Psychosocial treatments of alcohol use disorders 165Terry D. Schneekloth19 Pharmacologic interventions 175Renata Yang and Marian Fireman20 Treatment of extrahepatic manifestations of alcohol abuse 187Joaquim Fernandez]Sola21 Treatment of liver disease 197James Neuberger22 Treatment of alcoholic hepatitis 203Mark Thursz and Stephen Atkinson23 Liver transplantation in people with alcohol]related liver disease 215Santiago Tome and Michael R. Lucey24 Future directions: the need for early identification and intervention for patients with excessive alcohol use 223Andrea DiMartini Shari Rogal and Stephen PottsIndex 235