Aging and Troponin

Gary Tse is a medical scientist focusing on personalized care, health informatics and big data analytics. He is a professor in Hong Kong Metropolitan University and holds a joint position as reader at the University of Kent and public health consultant at the Medway Council in local government, UK. He serves as a professor at the Department of Cardiology and principal investigator at the Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, China. He is a visiting professor at the Faculty of Health and Medical Sciences, University of Surrey, and an honorary associate professor at the School of Pharmacy, University College London. He is an author of more than 500 scientific papers and an expert reviewer for >50 international journals in cardiology, cardiac electrophysiology, cardiovascular biology and epidemiology and five grant bodies from New Zealand, Poland, Sweden and the UK. Dr. Kelvin Yuen Kwong Chan is a distinguished researcher and medical scientist with extensive experience in genomics, prenatal diagnostics, and human disease mechanisms. After post-doctoral training, he served as Research Assistant Professor at The University of Hong Kong’s Department of Pathology. He then held key roles at Tsan Yuk Hospital and Queen Mary Hospital’s Prenatal Diagnostic Laboratory, overseeing prenatal testing services. At the Hong Kong Genome Institute, he led laboratory operations for Hong Kong’s first population-scale human genome project. With over 100 peer-reviewed publications—including in Nature Genetics and Cancer Research—he has over 3,000 citations. Dr. Chan is an active peer reviewer and editorial board member for multiple scientific journals. His research focuses on molecular profiling and genetic variation analysis in human diseases and cancers. He holds several professional memberships and academic appointments, including Honorary Associate Professor at HKU. Prof. Dr. Leonardo Roever is a distinguished clinical epidemiologist and healthcare data scientist with a prolific publication record of over 394 articles in high-impact journals such as The Lancet, Nature, and JAMA. He holds degrees from UNIT, UNIFESP, and UFU, including a PhD in Health Sciences and a postdoctoral fellowship in Neurosciences. As Senior Board Member at BMC Medical Research Methodology and a Specialty Chief Editor for Frontiers in Cardiovascular Medicine, he contributes extensively to scientific publishing. His expertise encompasses clinical research, meta-analyses, cardiovascular disease, metabolic syndrome, and global health. Dr. Roever is actively involved in international research networks, serving as CEO of BRAMETIS and collaborating with organizations like MRC and NIHR. With over 105,955 citations, he is recognized as a leading figure in evidence-based medicine, epidemiology, and health informatics. Dr. Giuseppe Biondi-Zoccai is an Associate Professor of Cardiology at Sapienza University of Rome, based in Latina, Italy. He specializes in advanced cardiology, biostatistics, evidence-based medicine, and cardiovascular imaging, with a focus on heart disease, inflammation, and interventional procedures. A prolific researcher, he has authored over 330 articles and leads the METCARDIO meta-analysis group. His expertise includes hypertension, atherosclerosis, heart failure, and myocardial infarction. Dr. Biondi-Zoccai is a member of the Heart Group of the Cochrane Collaboration and is recognized for his methodological contributions to evidence-based cardiology. His work significantly advances clinical research and systematic reviews in cardiovascular medicine, making him a prominent figure in Italian and international cardiology research.

• Section I. Pre-clinical: Technical aspects1. Traditional Versus High-sensitivity Troponin Assays2. Point-of-care Troponin Assays3. Age-related Changes of Troponin4. Intra-individual Variability in Troponin5. Inter-individual Variability in TroponinSection II. Clinical: Diagnosis6. Troponin As a Biomarker of Cardiac Injury7. Troponin As a Biomarker of Cardiac Dysfunction in Cancer Patients8. Effects of Age on Diagnostic Sensitivity and Specificity of Troponin in Patients with Suspected Myocardial Infraction9. Diagnosis of Acute Myocardial Infarction in Renal Impairment10. Sex-specific Cut-offs for Diagnosing Myocardial Infarction for Different Age Groups11. The Impact of Central and Peripheral Haemodynamics on Troponin LevelsSection III. Epidemiological: Prognosis and Model Development12. Troponin and Age-related Cognitive Decline13. Troponin and Age-related Renal Decline14. Troponin As a Prognostic Marker of Mortality in Pulmonary and Heart Disease15. Troponin in Sepsis16. Troponin As a Prognostic Marker of Mortality in the General Population17. Troponin in Acute and Chronic COVID-19 Infections18. Population Differences in Troponin19. Troponin As a Marker of Organ and Overall Biological Age20. Novel Biomedical Engineering Considerations Using Nanosensing to Increase Sensitivity of Troponin Detection21. Binding of DNA Aptamers to Troponin: Potential Clinical UsesSection IV. Summary22. Clinical Applicability: The Impact of Accelerated Diagnostic Protocols Incorporating High-sensitivity Troponin Assay in the Emergency Department23. Clinical Applicability: Perspectives From the Physician