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In Advancing Prion Science, the Institute of Medicinea (TM)s Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defensea (TM)s National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prionsa (TM) normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEsa "from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.
Rick Erdtmann and Laura B. Sivitz, Editors, Committee on Transmissable Spongiform Encephalopathies: Assessment of Relevant Science
1 Front Matter; 2 Executive Summary; 3 Summary; 4 1 Introduction; 5 2 Prion Diseases: An Overview; 6 3 Basic Biomedical Research on Transmissible Spongiform Encephalopathies; 7 4 Diagnostics for Transmissible Spongiform Encephalopathies; 8 5 Testing Blood for Evidence of Agents of Transmissible Spongiform Encephalopathies; 9 6 Surveillance for Transmissible Spongiform Encephalopathies in the United States; 10 7 Assessment of Strategies to Prevent and Treat Transmissible Spongiform Encephalopathies; 11 8 Infrastructure for Research on Transmissible Spongiform Encephalopathies; 12 9 Risks of Transmissible Spongiform Encephalopathies to the U.S. Military; 13 Appendix A: Agendas of Open Sessions of Committee Meetings; 14 Appendix B: Biographical Sketches; 15 Glossary; 16 Color Plates
National Research Council, Division of Behavioral and Social Sciences and Education, Institute of Medicine, and Families Board on Children, Youth, Steve Olson
Institute of Medicine, Board on the Health of Select Populations, and Transgender Health Issues and Research Gaps and Opportunities Committee on Lesbian, Gay, Bisexual
Institute of Medicine, Board on Population Health and Public Health Practice, Division of Health Promotion and Disease Prevention, Division of International Health
Institute of Medicine, Committee to Develop Methods Useful to the Department of Veteran Affairs in Estimating Its Physician Requirements, Joseph Lipscomb
Institute of Medicine, Medical Follow-up Agency, Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Laura Sivitz, Rick Erdtmann
Institute of Medicine, Medical Follow-up Agency, Committee to Study the Mortality of Military Personnel Present at Atmospheric Tests of Nuclear Weapons, Heather O'Maonaigh, Harriet Crawford, William F. Page, Susan Thaul
Institute of Medicine, Medical Follow-up Agency, Committee on Noise-Induced Hearing Loss and Tinnitus Associated with Military Service from World War II to the Present, Jane S. Durch, Lois M. Joellenbeck, Larry E. Humes
National Research Council, Institute of Medicine, Board on Life Sciences, Medical Follow-up Agency, and Acquisition of Medical Countermeasures Against Biological Warfare Agents Committee on Accelerating the Research, Development, Leslie Z. Benet, Jane S. Durch, Lois M. Joellenbeck
Institute of Medicine, Medical Follow-up Agency, Committee on a Strategy for Minimizing the Impact of Naturally Occurring Infectious Diseases of Military Importance: Vaccine Issues in the U.S. Military, Heather C. O'Maonaigh, Salem Fisseha, Susan Thaul, Stanley M. Lemon
Institute of Medicine, Medical Follow-up Agency, Committee to Assess the Safety and Efficacy of the Anthrax Vaccine, Brian L. Strom, Jane S. Durch, Lee L. Zwanziger, Lois M. Joellenbeck