Advances in Vascular Medicine

Professor David Abraham, Professor of Molecular Biology, University College London, London, UK.Dr Clive Handler, Consultant in Pulmonary Hypertension, The Royal Free Hospital, and Honorary Senior Lecturer, The Royal Free and University College School of Medicine, London, UK.Dr Michael Dashwood, Senior Lecturer in Biochemistry, University College London, London, UK.Dr Gerry Coghlan, Consultant Cardiologist, The Royal Free Hospital, London, UK.The Editors – two clinicians and two basic scientists, are all well known in their respective fields, and bring together this essential collaboration for this book dealing with scientific principles and clinical practice.The AuthorsThese are world famous leaders and internationally acclaimed experts in the field.

• Genetics and Gene Therapy.- Oligonucleotide Therapeutics to Treat Dyslipoproteinemia and Atherosclerosis.- Gene Delivery to Cardiovascular Tissue.- Animal Models to Study Vascular Disease.- Animal Models of Scleroderma: From Cellular and Molecular Mechanisms to Novel Antifibrotic Strategies.- Animal Models of Atherosclerosis.- Animal Models of the Endothelin System.- Molecules and Mediators and Therapeutic Applications.- Endothelin-1 and Systemic Sclerosis.- The Role of the Homeodomain Transcription Factor Nkx2-5 in the Cardiovascular System.- Cell Therapy for Cardiovascular Disease.- Tissue-Engineered Vascular Substitutes: New Models Toward Successful Small Diameter Grafts.- Role of Perivascular Adipose Tissue in Vascular Function.- Endothelium: Dysfunction and Repair.- Clinical Aspects of Vascular Biology.- Chronic Thromboembolic Pulmonary Hypertension.- Pathophysiology of Chronic Thromboembolic Pulmonary Hypertension (CTEPH).- Surgical Management of Chronic Thromboembolic Pulmonary Hypertension (CTEPH).- Imaging in Acute and Chronic Pulmonary Thromboembolic Disease.- Vascular Disease in Connective Tissue Diseases.- PAH in CTD – Clinical Trials Criteria and Performance.- Disease Progression in Systemic Sclerosis Associated Pulmonary Arterial Hypertension.- Connective Tissue Disease Associated Pulmonary Arterial Hypertension: Special Cases?.- Advances in Vascular Medicine.- Cardiovascular Disease.- Coronary Heart Disease in Women.- Recent Strategies to Improve Graft Performance in Patients Undergoing Coronary Artery Bypass Surgery. Are Best Results Achieved by Improved Surgical Techniques of Graft Preparation?.- Cardiovascular Risk Prediction by Measurement of Arterial Elastic Properties and Wall Thickness.- The Metabolic Syndrome.

From the reviews: "This collection presents focused discussions on the current understanding of endothelial function, atherosclerosis, pulmonary hypertension, systemic sclerosis, and chronic thromboembolic disease. ... It is directed at a diverse audience of scientists and physicians who specialize in vascular disease. ... provides clinical insight, which is useful for basic scientists and clinical researchers. It also offers vascular surgeons, cardiologists, rheumatologists, and vascular medicine physicians ... . The high quality writing offers stimulating and relevant ideas to both investigators and clinicians." (Judith L. Meadows, Doody's Review Service, May, 2010)