Advances in Statistical Methods for the Health Sciences

Applications to Cancer and AIDS Studies, Genome Sequence Analysis, and Survival Analysis

Inbunden, Engelska, 2006

Av Jean-Louis Auget, N. Balakrishnan, Mounir Mesbah, Geert Molenberghs

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During the past three decades, the use of statistical methods in the health sciences has become quite common, and many sophisticated methods have been developed for specific applications and problems. Presented in this work are chapters covering a broad range of recent advances of statistical methods in the health sciences written by internationally renowned experts. The volume is thematically classified into different areas of the health sciences according to the particular focus of the chapters. Specific topics covered include stochastic models in cancer and AIDS studies, statistical methods in genome sequence analysis, bioequivalence studies, randomized clinical trial designs, survival analysis and applications, and statistical methods in quality-of-life. Some chapters are reviews of active research, while others highlight recent developments, new methods, and practical real-world data. This comprehensive reference text will serve the health sciences community, as well as practitioners, researchers, and graduate students in applied probability and biostatistics.

Produktinformation

Utgivningsdatum2006-11-22
Mått210 x 297 x 35 mm
Vikt1 129 g
FormatInbunden
SpråkEngelska
SerieStatistics for Industry and Technology
Antal sidor540
Upplaga2007
FörlagBirkhauser Boston Inc
ISBN9780817643683

Tillhör följande kategorier

Prognostic Studies and General Epidemiology.- Systematic Review of Multiple Studies of Prognosis: The Feasibility of Obtaining Individual Patient Data.- On Statistical Approaches for the Multivariable Analysis of Prognostic Marker Studies.- Where Next for Evidence Synthesis of Prognostic Marker Studies? Improving the Quality and Reporting of Primary Studies to Facilitate Clinically Relevant Evidence-Based Results.- Pharmacovigilance.- Sentinel Event Methods for Monitoring Unanticipated Adverse Events.- Spontaneous Reporting System Modelling for the Evaluation of Automatic Signal Generation Methods in Pharmacovigilance.- Quality of Life.- Latent Covariates in Generalized Linear Models: A Rasch Model Approach.- Sequential Analysis of Quality of Life Measurements with the Mixed Partial Credit Model.- A Parametric Degradation Model Used in Reliability, Survival Analysis, and Quality of Life.- Agreement Between Two Ratings with Different Ordinal Scales.- Survival Analysis.- The Role of Correlated Frailty Models in Studies of Human Health, Ageing, and Longevity.- Prognostic Factors and Prediction of Residual Survival for Hospitalized Elderly Patients.- New Models and Methods for Survival Analysis of Experimental Data.- Uniform Consistency for Conditional Lifetime Distribution Estimators Under Random Right-Censorship.- Sequential Estimation for the Semiparametric Additive Hazard Model.- Variance Estimation of a Survival Function with Doubly Censored Failure Time Data.- Clustering.- Statistical Models and Artificial Neural Networks: Supervised Classification and Prediction Via Soft Trees.- Multilevel Clustering for Large Databases.- Neural Networks: An Application for Predicting Smear Negative Pulmonary Tuberculosis.- Assessing Drug Resistance in HIV Infection Using Viral LoadUsing Segmented Regression.- Assessment of Treatment Effects on HIV Pathogenesis Under Treatment By State Space Models.- Safety and Efficacy Assessment.- Safety Assessment Versus Efficacy Assessment.- Cancer Clinical Trials with Efficacy and Toxicity Endpoints: A Simulation Study to Compare Two Nonparametric Methods.- Safety Assessment in Pilot Studies When Zero Events Are Observed.- Clinical Designs.- An Assessment of Up-and-Down Designs and Associated Estimators in Phase I Trials.- Design of Multicentre Clinical Trials with Random Enrolment.- Statistical Methods for Combining Clinical Trial Phases II And III.- SCPRT: A Sequential Procedure That Gives Another Reason to Stop Clinical Trials Early.- Models for the Environment.- Seasonality Assessment for Biosurveillance Systems.- Comparison of Three Convolution Prior Spatial Models for Cancer Incidence.- Longitudinal Analysis of Short-Term Bronchiolitis Air Pollution Association Using Semiparametric Models.- Genomic Analysis.- Are There Correlated Genomic Substitutions?.- Animal Health.- Swiss Federal Veterinary Office Risk Assessments: Advantages and Limitations of The Qualitative Method.- Qualitative Risk Analysis in Animal Health: A Methodological Example.

From the reviews: "This edited volume is an outgrowth of an 'International Conference on Statistical Methods' so-called in the Health Sciences in 2004. It is a well presented volume with lists of tables and figures. ... Clearly this volume covers a wide range of topics pertaining to statistical methods in the area of health sciences. ... In summary, it is a welcome addition to the literature of statistical science." (Technometrics, Vol. 49 (3), August, 2007)