This book constitutes the refereed proceedings of the 13th International Conference on Advances in Optimization and Applications, OPTIMA 2022, held in Petrovac, Montenegro, during September 26–30, 2022. The 13 full papers included in this book were carefully reviewed and selected from 26 submissions. They were organized in topical sections as follows: ​mathematical programming; global optimization; discrete and combinatorial optimization; optimization and data analysis; game theory and mathematical economics; and applications.