Advances in Immunology

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

• 1. Malondialdehyde Epitopes as Targets of Immunity and the Implications for AtherosclerosisNikolina Papac Milicevic, Clara Jana-Lui Busch and Christoph J. Binder2. Factors That Regulate the Generation of Antibody-Secreting Plasma CellsYueh-Hsiang Yu and Kuo-I Lin3. Deep Profiling Human T Cell Heterogeneity by Mass CytometryYang Cheng and Evan W. Newell4. Germinal Center B-cell-associated Nuclear Protein (GANP) Involved in RNA Metabolism for B Cell MaturationNobuo Sakaguchi and Kazuhiko Maeda5. Advances in PET Detection of the Anti-Tumor T Cell ResponseMelissa N. McCracken, Richard Tavaré, Owen N. Witte and Anna Wu