This book constitutes the refereed proceedings of the 42nd Annual International Cryptology Conference, CRYPTO 2022, which was held in Santa Barbara, CA, USA, in August 2022. The total of 100 papers included in the 4-volume proceedings LNCS 13507, 13508, 13509, 13510, was reviewed and selected from 455 submissions. The papers were organized in the following topical sections: Cryptanalysis; randomness; quantum cryptography; advanced encryption systems; secure messaging; lattice-based zero knowledge; lattice-based signatures; blockchain; coding theory; public key cryptography; signatures, idealized models; lower bounds; secure hash functions; post-quantum cryptography; symmetric cryptanalysis; secret sharing and secure multiparty computation; unique topics; symmetric key theory; zero knowledge; and threshold signatures.