In this issue of Critical Care Nursing Clinics, guest editor Jennifer Manning brings her considerable expertise to the topic of Advances in Critical Care Nursing of Infectious Diseases. Top experts discuss topics such as antimicrobial stewardship and advanced ventilatory strategies, with an emphasis on early recognition and management of sepsis, infection control, and the unique challenges of caring for immunocompromised patients. Other topics include emerging viral infections, fluid and electrolyte management, pain management, sedation, and more.