This two-volume set CCIS 2691-2692 constitutes the revised selected papers of the 19th Colombian Congress on Advances in Computing, CCC 2025, held in Cajica, Colombia, during September 10–12, 2025.The 40 full papers, 10 short papers and 4 symposium papers included in these volumes were carefully reviewed and selected from 124 submissions. They are organized into the following topical sections: Part I: Artificial Intelligence and Machine Learning; Software Engineering and System Architecture; Education and Learning Technologies; and Cybersecurity, Data Management, and Computational Thinking.Part II: Image Processing and Computer Vision; Human-Computer Interaction and Simulation; Biomedical Signal Processing; Software Engineering, Security, Data Information and Knowledge; Biological Computing and Vision; Workshop de Aplicaciones de la Computación en Medicina; Workshop Mujeres en Computación; and Master’s and Doctoral Symposium.