Advances in Chromatography

Phyllis R. Brown UNIVERSITY OF RHODE ISLAND, Eli Grushka THE HEBREW UNIVERSITY OF JERUSALEM, JERUSALEM, ISRAEL

• 1. Planar Chips Technology of Separation Systems: A Developing Perspective in Chemical Monitoring I. Introduction II. Micromachining for Flow-Handling Components III. Theory of Miniaturization IV. Recent Examples 2. Molecular Biochromatography: An Approach to the Liquid Chromatographic Determination of Ligand-Biopolymer Interactions I. Introduction ll. The Concept of Molecular Biochromatography ill. Molecular Biochroma1ography Using Immobilized Human Serum Albumin IV. Molecular Biochroma1ography Using Other Immobilized Biopolymers 3. Expert Systems in Chromatography I. Introduction II. Structure of Expert Systems III. Development of an Expert System IV. Some Future Developments V. Potential of Expert Systems VI. Application of Expert Systems in Chromatography VII. Related Computer Programs VIII. Intelligent Laboratory Systems 4. Information Potential of Chromatographic Data for Pharmacological Classification and Drug Design I. Introduction II. Hydrophobicity as a Molecular Property III. Chromatography in Parametrization of Hydrophobicity IV. Structural Information Generated Chromatographically and Not Related to Hydrophobicity 5. Fusion Reaction Chromatography: A Powerful Analytical Technique for Condensation Polymers I. Introduction II. Hydrolysis Ill. Acidic Ether Cleavage IV. Reaction Procedures V. Polymer Systems Examined VI. Related Polymer Systems VII. Conclusion 6. The Role of Enantioselective Liquid Chromatographic Separations Using Chiral Stationary Phases in Pharmaceutical Analysis