Advancement in Animal Handling and Generative AI for Pre-clinical Studies

AYUSH encompasses traditional Indian medical systems like Ayurveda, Yoga, Naturopathy, Unani, Siddha, and Homeopathy. The CCRAS, funded by AYUSH, supports research programs to scientifically validate traditional medicine’s effi□cacy.

• 1 AI-driven mathematical modelling of perturbated cancer metabolic pathways: Predicting doxorubicin-induced PHGDH inhibition through the PI3K/Akt/mTOR pathway Victor Pradhan and Preetha Bhadra2 Design and synthesis of novel benzimidazole-pyrazoline hybrid molecules as anticancer agent Gopal Krishna Padhy and Jagadeesh Panda3 Ionic gelation technique using biodegradable polymer for stabilized and sustained oral delivery of nano protein Prasanna Parida, Amiya Kumar Prusty, Chinmaya Sahoo, Sujit Dash, Bikash Ranjan Jena, and Kirtimaya Mishra4 Overcoming hurdles in oral protein and peptide drug delivery: Strategies for future prospective Prasanna Parida, Amiya Kumar Prusty, Rajat Kumar Prusty, Bikash Ranjan Jena, Debabrata Panda, and Sanjoy Das5 The impact of mirror therapy in improving hand motor function following stroke DattaSai Pamidimarri, Nagarjuna Narayansetti, Preety Kumari, SriKavya Grandhi, Soumya Saswati Panigrahi, and Ravi Kumar Kalari6 Modifying the triphasic liver CT scan protocol to achieve optimal vascular contrast Aswathi P., Abhijith S., Anushka Valeska Fernandes, and Jayeeta Dandapat7 Network pharmacology and molecular docking analysis for elucidation of mechanism of action and molecular targets of Commiphora wightii in treatment of atherosclerosis Sangeeta Chhotaray, Kanika Verma, Pralaya Kumar Sahoo, and Soumya Jal8 Investigating the potential of medicinal plant essential oils as a powerful medication B. Jyotirmayee, Ipsita Priyadarsini Samal, Sameer Jena, and Gyanranjan Mahalik9 Profiling of bioactive compounds in methanolic leaf extract of Artemisia nilagirica (C.B.Cl) Pamp. through GC-MS and In-silico study of some selected compound Sagorika Panda, Kalpita Bhatta, Himansu Bhusan Samal, and Pratikshya Mohanty10 Design and development of Psidium Guajava Leaf extract loaded topical emulgel Sk Hasibur Ali, Sonalika Mahapatra, Tamosa Mukherjee,Mamalisa Sahoo, Monali Priyadarshini Mishra, Himanshu Bhusan Samal, and Yashwant Giri11 Design and development of topical herbal antimicrobial gel loaded with cadamba leaf extract Kuldip Singh, Tamosa Mukherjee, Sonali Bhujabal, Yashwant Giri, Gurudutta Pattnaik, Amulyaratna Behera, and Biswaranjan Mohanty12 Development of in-situ ocular gel containing topiramate to understand its effect in intraocular pressure Biswajeet Puhan, Aradhana Panigrahi, Guptanjali Sahu, Yashwant Giri, Bikash Ranjan Jena, and Gurudutta Pattnaik13 Formulation and evaluation of Amphotericin-B loaded topical antifungal organogel Rozalika Mohanty, Himansu Bhusan Samal, Aradhana Panigrahi, Yashwant Giri, and Gurudutta Pattnaik14 Formulation and evaluation of vildagliptin loaded in-situ gel for ocular drug delivery: An improved approach towards management of diabetic retinopathy Pritish Kanungo, Subhashree Das, Debaprasad Routray, Guptanjali Sahu, Yashwant Giri, and Gurudutta Pattnaik15 Design, optimization and evaluation of telmisartan fast dissolving film employing mango kernel starch as a new natural super disintegrant Medisetty Gayatri Devi, Santosh Kumar R., and Anusha Kusuma16 Deeper and updated insights on breast cancer Anup Kumar Dash and Sucharita Babu17 UV-visible spectrophotometric method for estimation of Tacrolimus in bulk and different pharmaceutical capsules Babita Adhikary and Ladi Alik Kumar18 Recent advancement in targeted drug delivery systems for cancer treatment: Updated review Jyoshna Rani Dash, Omprakash Pradhan, Rajesh Kumar Pradhan, Gurudutta Pattnaik, and Biswakanth Kar19 IONPs as strategic nanotools for cancer therapy: Concise updates on facile synthetic methods and stabilization Jnanranjan Panda, Sagar Rout, Gurudutta Pattnaik, Himansu Bhusan Samal, Bikash Ranjan Jena, and Bhabani Sankar Satapathy20 Development of stability indicating RP-HPLC method for simultaneous estimation of sacubitril and valsartan in pure and pharmaceutical dosage form Kumar Dhiraj and Himansu Bhusan Samal21 Development of sophisticated RP-HPLC approach for quantifying lornoxicam in API and pharmaceutical formulation Biswa Mohan Sahoo, Chandan Kumar Brahma, Bikash Ranjan Jena, Kirtimaya Mishra, Debabrata Panda, Satya Narayan Tripathy, and Dipika Rani Sahu22 COVID-19: Immergence, molecular mechanism of transmission and pathogenesis Chinmaya Chidananda Behera, Sagar K Mishra, Biswajit Mishra, Gurudutta Pattnaik, Bikash Ranjan Jena, and Suman K Mekap