Advanced Therapy for Hepatitis C

Professor Geoff McCaughan is Director of the AW Morrow Liver Centre and Physician in Charge at the Australian National Liver Transplant Unit.John McHutchison is a professor of medicine at Duke University Medical Center, and since 2002, Director of the DCRI’s Gastroenterology and Hepatology Research division.

• Contributors viiPreface xiSection I Foundations for Understanding Antiviral Therapies in HCV1 HCV Replication 3Michael R. Beard2 Hepatitis C Virus Genotypes 12Scott A. Read and Mark W. Douglas3 Immune Responses to HCV: Implications for Therapy 17David G. Bowen4 Mechanisms of Action of Antiviral Drugs: The Interferons 25Edmund Tse and Michael R. Beard5 Pharmacology and Mechanisms of Action of Antiviral Drugs: Ribavirin Analogs 36Fred Poordad and Grace M. Chee6 Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors 43Lotte Coelmont Leen Delang Mathy Froeyen Piet Herdewijn and Johan Neyts7 Pharmacology and Mechanisms of Action of Antiviral Drugs: Protease Inhibitors 53Laurent Chatel-Chaix Martin Baril and Daniel Lamarre8 Measuring Antiviral Responses 60Jean-Michel Pawlotsky and Stephane ChevaliezSection II Efficacy and Clinical Use of Antiviral Therapies9 Genotype 1: Standard Treatment 67Rebekah G. Gross and Ira M. Jacobson10 Individually Tailored Treatment Strategies in Treatment-na¨ive Chronic Hepatitis C Genotype 1 Patients 74Johannes Wiegand and Thomas Berg11 Genotype 1 Relapsers and Non-responders 84Salvatore Petta and Antonio Craxì12 Standard Therapy for Genotypes 2/3 90Kenneth Yan and Amany Zekry13 Altered Dosage or Durations of Current Antiviral Therapy for HCV Genotypes 2 and 3 97Alessandra Mangia Leonardo Mottola and Angelo Andriulli14 Genotypes 2 and 3 Relapse and Non-response 104Stella Martinez Jose Maria Sanchez-Tapias and Xavier Forns15 Hepatitis C Genotype 4 Therapy: Progress and Challenges 113Sanaa M. Kamal16 Antivirals in Acute Hepatitis C 127Heiner Wedemeyer17 Antivirals in Cirrhosis and Portal Hypertension 132Diarmuid S. Manning and Nezam H. Afdhal18 Treatment of Recurrent Hepatitis C Following Liver Transplantation 140Ed Gane19 Antiviral Treatment in Chronic Hepatitis C Virus Infection with Extrahepatic Manifestations 150Benjamin Terrier and Patrice Cacoub20 Cytopenias: How they Limit Therapy and Potential Correction 160Mitchell L. Shiffman21 The Problem of Insulin Resistance and its Effect on Therapy 169Venessa Pattullo and Jacob George22 HIV and Hepatitis C Co-infection 177Gail V. Matthews and Gregory J. Dore23 HCV and Racial Differences 185Andrew J. Muir24 HCV and the Pediatric Population 190Kathleen B. Schwarz25 New Horizons: IL28 Direct-acting Antiviral Therapy for HCV 196Alexander J. Thompson John G. McHutchison and Geoffrey W. McCaughanIndex 215

"I think it is an invaluable respository of knowledge for anyone embarking on a career caring for patients with viral hepatitis. This book summarises the hard won clinical knowledge of the past 20 years." (The Irish Medical Journal, 1 January 2013)