This book constitutes the thoroughly refereed proceedings of the international workshops associated with the 34th International Conference on Advanced Information Systems Engineering, CAiSE 2022, which was held in Leuven, Belgium, during June 6-10, 2022.The workshops included in this volume are:·         BC4IS: Second International Workshop on Blockchain for Information Systems·         ISESL: Second International Workshop on Information Systems Engineering for Smarter Life·         KET4DF: 4th International Workshop on Key Enabling Technology for Digital FactoriesThey reflect a broad range of topics and trends ranging from blockchain technologies via digital factories, ethics, and ontologies, to the agile methods for business and information systems.The 11 full papers and 1 short paper presented in this book were carefully reviewed and selected from 23 submissions.