The marked increase in life-expectancy in Down syndrome since the 1990s, although a very good sign in itself, raises important questions regarding the health issues, cognitive involution and social and professional inclusion of people with the condition. In this text, a large group of leading specialists have supplied a series of papers on many aspects of this issue, ranging from epidemiology, genetics, medical issues, Alzheimer's disease, cognition and language, to sexual behaviour and contraception, family issues, professional orientation and work experiences. This book should be of interest to physicians, psychologists, social workers and educators working in the field who wish to provide evidence-based interventions for persons with Down syndrome advancing in age.