Adoptive Immunotherapy

• Exploiting Dendritic Cells for Active Immunotherapy of Cancer and Chronic Infection.- A Mathematical Approach for Optimizing Dendritic Cell-Based Immunotherapy.- Delivery of Tumor Antigens to Dendritic Cells Using Biodegradable Microspheres.- RNA Transfection of Dendritic Cells.- Isolation and Generation of Clinical-Grade Dendritic Cells Using the CliniMACS System.- Generation of Clinical-Grade Monocyte-Derived Dendritic Cells Using the CliniMACS System.- Adenoviral Transduction of Dendritic Cells.- Generation of Autologous Peptide- and Protein-Pulsed Dendritic Cells for Patient-Specific Immunotherapy.- Phenotypical and Functional Characterization of Clinical-Grade Dendritic Cells.- Dendritic Cells in Clinical Trials for Multiple Myeloma.- Identification of Tumor-Associated Autoantigens With SEREX.- Application of Proteomics and Protein Analysis for Biomarker and Target Finding for Immunotherapy.- Isolation and Expansion of Tumor-Reactive Cytotoxic T-Cell Clones for Adoptive Immunotherapy.- Tracking Adoptively Transferred Antigen-Specific T-Cells With Peptide/MHC Multimers.- Gene Transfer of MHC-Restricted Receptors.- Immunotherapy With CTL Restricted by Nonself MHC.- Designing TCR for Cancer Immunotherapy.- Isolation and Expansion of Tumor-Specific CD4+T-Cells by Means of Cytokine Secretion.- Methods for the Ex Vivo Characterization of Human CD8+T Subsets Based on Gene Expression and Replicative History Analysis.- Regulatory T-Cells in Antitumor Therapy Isolation and Functional Testing of CD4+CD25+Regulatory T-Cells.- Monoclonal Antibody-Based Strategies in Autoimmunity and Transplantation.- Producing Bispecific and Bifunctional Antibodies.- Antibody-Cytokine Fusion Proteins for the Therapy of Cancer.- Synthesis and Biological Evaluation of a Paclitaxel Immunoconjugate.- Cytotoxic Tumor Targeting With scFv Antibody-Modified Liposomes.- Intravenous Immunoglobulin Treatment for Fibrosis, Atherosclerosis, and Malignant Conditions.- Study of T-Cell Costimulatory Blockade In Vivo at a Single-Cell Level.- Stem Cell Transplantation: Graft-Mediated Antileukemia Effects.- Influence of Radiation Protocols on Graft-vs-Host Disease Incidence After Bone-Marrow Transplantation in Experimental Models.- Induction of Chimerism and Tolerance Using Freshly Purified or Cultured Hematopoietic Stem Cells in Nonmyeloablated Mice.- Induction of Mixed vs Full Chimerism to Potentiate GVL Effects After Bone-Marrow Transplantation.- Application of Donor Lymphocytes Expressing a Suicide Gene for Early GVL Induction and Later Control of GVH Reactions After Bone-Marrow Transplantation.

"...a comprehensive and authoritative collection of currently used protocols for adoptive immunotherapy in both pre-clinical and clinical settings." - Immunology News "...will be not only useful for basic researchers but also clinical scientists aiming to translate basic research to a clinical setting." - Immunology and Cell Biology