Adjuvant Therapy of Breast Cancer

• I. Rationale and Methods for Studying Adjuvant Systemic Therapy.- 1. Evolving concepts in the adjuvant systemic therapy of operable breast cancer.- 2. Statistical methods for early breast cancer trials.- II. Results of Clinical Studies.- 3. The nature of the benefit.- 4. Adjuvant endocrine therapy of breast cancer.- 5. Adjuvant chemotherapy of axillary lymph-node-positive breast cancer.- 6. The node-negative problem: To treat or not to treat.- III. Special Problems.- 7. Defining the high-risk breast cancer patient.- 8. Models for weighing benefits and toxicities.- 9. Financial considerations in the use of adjuvant chemotherapy.- 10. The use of adjuvant therapy in patients treated with conservative surgery and radiotherapy.- 11. Treating the relapsed patient.- IV. Future Directions.- 12. Unanswered questions in the adjuvant therapy of breast cancer.- 13. Neoadjuvant chemotherapy.- 14. Altering cell kinetics with endocrine therapy.- 15. Polypeptide growth factors: Their potential value in the management of breast cancer patients.- 16. Immunotherapy of breast cancer.- 17. Breast cancer chemoprevention.- Appendices.- I. Consensus statements from panels convened by The National Cancer Institute in 1980, 1985, 1990.- II. List of completed and ongoing randomized clinical trials addressing questions related to the use of adjuvant systemic therapy to treat resectable breast cancer.

'Overall, this book is a useful review Volume containing thoughtful and up-to-date information on the optimal use of adjuvant therapy for breast cancer. It will be a valuable addition to the library of the practicing clinical oncologist.' Journal of the Nat. Cancer Inst. 85:10 1993