Acetaminophen Toxicity

Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming the drug in various situations and effective treatments of toxicity. Divided into two parts, the foundational aspects of the book cover the mechanism of toxicity in a detailed manner, beginning with the history of acetaminophen and then delving into newly explored areas of genetics, proteomics, and metabolomics. The second half discusses clinical practices and examines where further research and therapeutic approaches may be headed. This part answers key questions about who to treat, what are the exceptions, how long do you treat, how much antidote do you need, when are other treatments necessary, and what are those other treatments. With contributions from experts in the field, the book is a thorough, well-researched, and a valuable reference for scientists, researchers, and clinicians engaged in pursuing better and more accurate diagnosis and treatment of patients with of acetaminophen toxicity.

• Includes comprehensive coverage of the pharmacological mechanisms of toxicity
• Provides risk analysis regardless of patient presentation or timing of ingestion or amount with algorithmic support
• Covers how to determine level of toxicity and need for liver transplant with algorithmic support
• Outlines new therapeutic approaches