Del 11 - Wiley Series in Drug Discovery and Development

ABC Transporters and Multidrug Resistance

Inbunden, Engelska, 2009

Av Ahcène Boumendjel, Jean Boutonnat, Jacques Robert, France) Boumendjel, Ahcene (University de Grenbole, France) Boutonnat, Jean (CHU A. Michallon, France) Robert, Jacques (Institut Bergonie

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A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs.ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

Produktinformation

Utgivningsdatum2009-07-30
Mått161 x 243 x 27 mm
Vikt771 g
FormatInbunden
SpråkEngelska
SerieWiley Series in Drug Discovery and Development
Antal sidor480
FörlagJohn Wiley & Sons Inc
ISBN9780470227343

Tillhör följande kategorier

Biokemi inom Naturvetenskap och teknik
Farmakologi inom Medicin

Ahcéne Boumendjel is Professor of Medicinal Chemistry at the University of Grenoble School of Pharmacy, France. Jean Boutonnat is an Assistant Professor and Hospital Practitioner at the Grenoble Medical School and Université Joseph Fourier of Grenoble, France.Jacques Robert is Professor and Head of the Laboratory of Pharmacology of Anticancer Agents at Institut Bergonié and Université Victor Segalen Bordeaux 2, France.

PREFACE ixCONTRIBUTORS xiINTRODUCTION: WHAT IS MULTIDRUG RESISTANCE? 1Jonathan A. Sheps and Victor LingPART I ABC PROTEINS: AN OVERVIEW AND DESCRIPTION OF THE STRUCTURE, GENOME, NORMAL TISSUE EXPRESSION, PHYSIOLOGICAL ASPECT, AND MECHANISM OF ACTION 151 The P-glycoprotein 170: Just a multidrug resistance protein or a protean molecule? 17Fabienne Grandjean-Forestier, Christophe Stenger, Jacques Robert, Mireille Verdier, and Marie-Hélène Ratinaud2 Multidrug resistance-associated protein (MRP/ABCC proteins) 47Mylène Honorat, Charles Dumontet, and Lea Payen3 ABCG2: A new challenge in cancer drug resistance 83Orsolya Polgar, Robert W. Robey, Kin Wah To, John Deeken, Patricia A. Fetsch, and Susan E. BatesPART II ABC PROTEINS AND ONCOLOGY: EXPRESSION, DETECTION, AND IMPLICATION OF ABC PROTEINS IN HEMATOLOGICAL MALIGNANCIES AND SOLID TUMORS 1194 Expression, detection, and implication of ABC proteins in acute myeloblastic leukemia 121Ollivier Legrand, Ruo-Ping Tang, and Jean-Pierre Marie5 ABC proteins and oncology: Expression, detection, and implication of ABC proteins in solid tumors 143Jean François Bernaudin, Anne Fajac, Jocelyne Fleury-Feith, Khaldoun Kerrou, and Roger LacavePART III ABC PROTEINS AND PATHOGENIC MICROORGANISMS 1776 ABC transporters and resistance to antibiotics 179Serge Michalet and Marie-Geneviève Dijoux-Franca7 ABC proteins involved in protozoan parasite resistance 195Bruno PradinesPART IV MULTIDRUG RESISTANCE (MDR) MODULATION THROUGH INHIBITION OF ABC TRANSPORTERS: DESIGN OF INHIBITORS AND MECHANISM OF ACTION 2398 Reversal agents for P-glycoprotein-mediated multidrug resistance 241Hamid Morjani and Claudie Madoulet9 Reversal agents of multidrug resistance mediated by multidrug resistance-associated proteins (MRPs) 261Ahcène Boumendjel, Anne Florin, and Jean Boutonnat10 Reversal agents for breast cancer resistance protein (BCRP)-mediated multidrug resistance 289Jean Boutonnat, Anne Florin, and Ahcène Boumendjel11 Strategies to overcome drug resistance in acute and chronic leukemias 315Eric Solary, Vincent Ribrag, and Stéphane de Botton12 Multidrug resistance reversal in solid tumors 349Tatiana Bogush and Jacques RobertPART V BIOLOGICAL AND CLINICAL ASPECTS OF MULTIDRUG RESISTANCE: THE ROLE OF THE TRANSPORTERS AT THE MAIN PROTECTION BARRIERS (ABCB1, ABCC1, ABCC2, ABCG2) ON THE BIOAVAILABILITY OF MANY TYPES OF DRUGS AND MEDICATIONS 36313 ABC superfamily transporters at the human blood–brain barrier 365Jean-Michel Scherrmann14 The role of ABC transporters at the intestinal barrier 385Roos L. Oostendorp, Jos H. Beijnen, and Jan H.M. Schellens15 Genetic polymorphisms in ABC transporters 411Leslie W. Chinn and Deanna L. KroetzPERSPECTIVES 437INDEX 441