Michael W. Adler, Emeritus Professor of Genitourinary Medicine/Sexually Transmitted Diseases, University College London Medical School, London, UK; Simon G. Edwards, Consultant GU/HIV Physician, Camden Provider Services, Mortimer Market Centre, London, UK; Robert F. Miller, Professor, Reader in Clinical Infection and Honorary Consultant Physician, University College London Medical School, London, UK; Gulshan Sethi, Consultant Physician in Sexual Health and HIV, Guy's and St Thomas' NHS Foundation Trust, London, UK; Ian G. Williams, Senior Lecturer and Honorary Consultant Physician, University College London Medical School, London, UK

• Contributors viiPreface ix1 Development of the Epidemic 1B. Sultan and M. W. Adler2 Immunology of HIV-1 Infection 6M. Noursadeghi and D. Pillay3 Viral Assays Used in the Diagnosis and Management of HIV Infection 10A. M. Geretti and P. Vitiello4 HIV Testing: Strategies to Prevent Late Diagnosis 15A. Palfreeman and E. Fox5 Clinical Staging and Natural History of Untreated HIV Infection 20M. Tenant-Flowers and A. Mindel6 Routine Assessment and Follow-up of the Newly Diagnosed HIV-positive Individual 25L. Waters and D. Asboe7 Tumours in HIV 29M. Bower8 The Lung and HIV 35S. Doffman and R. F. Miller9 HIV and Tuberculosis Co-infection 42F. Perrin, R. Breen and M. Lipman10 The Gut and HIV 48B. Gazzard and M. Nelson11 Viral Hepatitis and Liver Disease 54R. Gilson and H. Price12 Neurological Manifestations 59H. Manji and R. F. Miller13 The Eye and HIV 67C. Younan W. Lynn and S. Lightman14 The Skin and HIV 72R. Morris-Jones and E. Higgins15 The Kidney and HIV 78J. Booth and J. Connolly16 Sexually Transmitted Infections and HIV 83P. French17 Women and HIV 87C. Wilkinson and D. Mercey18 HIV Infection in Children 91P. McMaster and S. Stokes19 Antiretroviral Drugs 97P. Benn, G. Sethi and I. G. Williams20 Pharmacopoeia of Treatments 101J. Minton, G. Sethi and S. G. Edwards21 Psychological and Mental Health Issues 108B. Hedge22 Strategies for Preventing HIV Transmission 114J. Imrie and G. J. Hart23 Patient and Community Perspective 120G. Brough and N. Lubega24 The Role of Patient Engagement 123C. SandfordIndex 127

“An authoritative guide to the epidemiology, incidence, testing and diagnosis and management of HIV and AIDS.”  (MedReview, 1 November 2012)“This excellent new edition has been updated to incorporate developments and current issues in the management of HIV … This edition is highly recommended as the best available overview on HIV and AIDS (acquired immunodeficiency syndrome).”  (British Journal of Hospital Medicine, 1 August 2012)

Michael W. Adler, Emeritus Professor of Genitourinary Medicine/Sexually Transmitted Diseases, University College London Medical School, London, UK; Simon G. Edwards, Consultant GU/HIV Physician, Camden Provider Services, Mortimer Market Centre, London, UK; Robert F. Miller, Professor, Reader in Clinical Infection and Honorary Consultant Physician, University College London Medical School, London, UK; Gulshan Sethi, Consultant Physician in Sexual Health and HIV, Guy's and St Thomas' NHS Foundation Trust, London, UK; Ian G. Williams, Senior Lecturer and Honorary Consultant Physician, University College London Medical School, London, UK

• Contributors viiPreface ix1 Development of the Epidemic 1B. Sultan and M. W. Adler2 Immunology of HIV-1 Infection 6M. Noursadeghi and D. Pillay3 Viral Assays Used in the Diagnosis and Management of HIV Infection 10A. M. Geretti and P. Vitiello4 HIV Testing: Strategies to Prevent Late Diagnosis 15A. Palfreeman and E. Fox5 Clinical Staging and Natural History of Untreated HIV Infection 20M. Tenant-Flowers and A. Mindel6 Routine Assessment and Follow-up of the Newly Diagnosed HIV-positive Individual 25L. Waters and D. Asboe7 Tumours in HIV 29M. Bower8 The Lung and HIV 35S. Doffman and R. F. Miller9 HIV and Tuberculosis Co-infection 42F. Perrin, R. Breen and M. Lipman10 The Gut and HIV 48B. Gazzard and M. Nelson11 Viral Hepatitis and Liver Disease 54R. Gilson and H. Price12 Neurological Manifestations 59H. Manji and R. F. Miller13 The Eye and HIV 67C. Younan W. Lynn and S. Lightman14 The Skin and HIV 72R. Morris-Jones and E. Higgins15 The Kidney and HIV 78J. Booth and J. Connolly16 Sexually Transmitted Infections and HIV 83P. French17 Women and HIV 87C. Wilkinson and D. Mercey18 HIV Infection in Children 91P. McMaster and S. Stokes19 Antiretroviral Drugs 97P. Benn, G. Sethi and I. G. Williams20 Pharmacopoeia of Treatments 101J. Minton, G. Sethi and S. G. Edwards21 Psychological and Mental Health Issues 108B. Hedge22 Strategies for Preventing HIV Transmission 114J. Imrie and G. J. Hart23 Patient and Community Perspective 120G. Brough and N. Lubega24 The Role of Patient Engagement 123C. SandfordIndex 127

“An authoritative guide to the epidemiology, incidence, testing and diagnosis and management of HIV and AIDS.”  (MedReview, 1 November 2012)“This excellent new edition has been updated to incorporate developments and current issues in the management of HIV … This edition is highly recommended as the best available overview on HIV and AIDS (acquired immunodeficiency syndrome).”  (British Journal of Hospital Medicine, 1 August 2012)

Michael W. Adler, Emeritus Professor of Genitourinary Medicine/Sexually Transmitted Diseases, University College London Medical School, London, UK; Simon G. Edwards, Consultant GU/HIV Physician, Camden Provider Services, Mortimer Market Centre, London, UK; Robert F. Miller, Professor, Reader in Clinical Infection and Honorary Consultant Physician, University College London Medical School, London, UK; Gulshan Sethi, Consultant Physician in Sexual Health and HIV, Guy's and St Thomas' NHS Foundation Trust, London, UK; Ian G. Williams, Senior Lecturer and Honorary Consultant Physician, University College London Medical School, London, UK

• Contributors viiPreface ix1 Development of the Epidemic 1B. Sultan and M. W. Adler2 Immunology of HIV-1 Infection 6M. Noursadeghi and D. Pillay3 Viral Assays Used in the Diagnosis and Management of HIV Infection 10A. M. Geretti and P. Vitiello4 HIV Testing: Strategies to Prevent Late Diagnosis 15A. Palfreeman and E. Fox5 Clinical Staging and Natural History of Untreated HIV Infection 20M. Tenant-Flowers and A. Mindel6 Routine Assessment and Follow-up of the Newly Diagnosed HIV-positive Individual 25L. Waters and D. Asboe7 Tumours in HIV 29M. Bower8 The Lung and HIV 35S. Doffman and R. F. Miller9 HIV and Tuberculosis Co-infection 42F. Perrin, R. Breen and M. Lipman10 The Gut and HIV 48B. Gazzard and M. Nelson11 Viral Hepatitis and Liver Disease 54R. Gilson and H. Price12 Neurological Manifestations 59H. Manji and R. F. Miller13 The Eye and HIV 67C. Younan W. Lynn and S. Lightman14 The Skin and HIV 72R. Morris-Jones and E. Higgins15 The Kidney and HIV 78J. Booth and J. Connolly16 Sexually Transmitted Infections and HIV 83P. French17 Women and HIV 87C. Wilkinson and D. Mercey18 HIV Infection in Children 91P. McMaster and S. Stokes19 Antiretroviral Drugs 97P. Benn, G. Sethi and I. G. Williams20 Pharmacopoeia of Treatments 101J. Minton, G. Sethi and S. G. Edwards21 Psychological and Mental Health Issues 108B. Hedge22 Strategies for Preventing HIV Transmission 114J. Imrie and G. J. Hart23 Patient and Community Perspective 120G. Brough and N. Lubega24 The Role of Patient Engagement 123C. SandfordIndex 127

“An authoritative guide to the epidemiology, incidence, testing and diagnosis and management of HIV and AIDS.”  (MedReview, 1 November 2012)“This excellent new edition has been updated to incorporate developments and current issues in the management of HIV … This edition is highly recommended as the best available overview on HIV and AIDS (acquired immunodeficiency syndrome).”  (British Journal of Hospital Medicine, 1 August 2012)