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This book covers ageing from a fundamental cell biological perspective. The evolution and developmental genetics of senescence are explained clearly. All the various theories of ageing -- the Hayflick limit and telomeric shortening as a possible biological clock, the impacts of somatic mutations, oxidative stress, accumulation of waste materials in cells with age -- are explained and critically assessed. The author presents vivid case accounts about disorders that open windows on to the ageing process. The impacts of ageing on the brain and nervous system are given special attention, as are the effects of caloric restriction on maximum lifespan.
Professor Emeritus of Immunology at UCLA and an internationally recognized authority on cellular immune reactions, William R. Clark is the author of The New Healers: Molecular Medicine in the Twenty-First Century, Sex and the Origins of Death, and At War Within: The Double Edged Sword of Immunity, all published by OUP.
INTRODUCTION ; 1. Aging, Senescence, and Lifespan ; 2. The Nature of Cellular Senescence and Death ; 3. The Evolution of Senescence and Death ; 4. Of Embryos and Worms and Very Old Men: The Developmental Genetics of Senescence and Lifespan ; 5. Human Genetic Diseases that Mimic the Aging Process ; 6. Cycling to Senescence ; 7. Replicative Immortality: Cancer and Aging ; 8. Caloric Restriction and Maximum Lifespan ; 9. With Every Breath We Take: Oxidative Stress and Cellular Senescence ; 10. The Aging Brain ; 11. A Conditional Benefit
"Clark effortlessly takes readers from the simple to the complex, from a discussion of single-celled organisms to human beings.... He also does a nice job of exploring the causes of Alzheimer's disease, various forms of cancer and an array of genetic disorders that afflict the young by making them age prematurely.... Neatly informative."--Publishers Weekly
CLARK, Clark, Janine A. Clark, Francesco Cavatorta, University of Guelph) Clark, Janine A. (Associate Professor of Political Science, Associate Professor of Political Science, University of Laval) Cavatorta, Francesco (Associate Professor of Political Science, Associate Professor of Political Science
Kate Clark, Amanda Markwick, Royal Conservatory of The Hague) Clark, Kate (Teacher of Historical Flutes and Lecturer, Teacher of Historical Flutes and Lecturer, Fanny Hensel Musikschule) Markwick, Amanda (Teacher, Teacher, CLARK, Clark
Clark, David M. Clark, Christopher G. Fairburn, London) Clark, David M. (Professor of Psychology, Professor of Psychology, Institute of Psychiatry, University of Oxford) Fairburn, Christopher G. (Consultant Psychiatrist, Warneford Hospital, Oxford; Wellcome Trust Senior Lecturer, Department of Psychiatry, Consultant Psychiatrist, Warneford Hospital, Oxford; Wellcome Trust Senior Lecturer, Department of Psychiatry
Ian Clark, Nicholas J. Wheeler, University of Cambridge) Clark, Ian (Teaching Fellow in Defence Studies, Teaching Fellow in Defence Studies, International Institute for Strategic Studies) Wheeler, Nicholas J. (Research Fellow, Department of War Studies, King's College, London; Research Associate, Research Fellow, Department of War Studies, King's College, London; Research Associate, William R. Clark
William R. Clark, USA) Clark, William R. (Professor and Chair Emeritus of Immunology, Professor and Chair Emeritus of Immunology, Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles