50 Studies Every Palliative Care Doctor Should Know

Dr. David Hui, MD, MSc is an Associate Professor in the Department of Palliative Care, Rehabilitation, and Integrative Medicine, with a joint appointment to the Department of General Oncology at The University of Texas MD Anderson Cancer Center, Houston, Texas. He completed his medical oncology training at the British Columbia Cancer Agency in British Columbia, Canada, and completed a palliative oncology fellowship at the University of Texas MD Anderson Cancer Center. His research interests include integration of supportive/palliative care into oncology practice, clinical trials investigating interventions for symptom control, and prognostication.Dr. Akhila Reddy, MD is an Associate Professor in the department of Palliative, Rehabilitation, and Integrative Medicine at The University of Texas MD Anderson Cancer Center in Houston, Texas. Her research interests include opioids, opioid induced neurotoxicity and pain management in cancer patients. She has authored several publications determining safe and effective opioid rotation ratios for pain management in cancer patients.One of the pioneering members of the hospice and palliative medicine movement in North America, Dr. Eduardo Bruera, MD has educated generations of hospice and palliative medicine clinicians. Founder of two of the leading palliative care programs in North America (in Edmonton, Canada and The University of Texas MD Anderson Cancer Center), his impact extends far beyond his direct trainees, many of whom have gone on to lead programs of their own nationally and internationally. Mentor to innumerable observers, visiting scientists, and mentees, he has contributed to the development of hospice and palliative medicine clinical and research expertise across the globe. A prolific physician scientist and sought after speaker, he has created an enduring legacy for the field.

• Section 1: Palliative CareChapter 1: Early Palliative Care for Patients with Metastatic Non-Small Cell Lung CancerNathan A. Gray and Thomas W. LeBlanc Chapter 2: Early Palliative Care for Patients with Advanced CancerDavid HuiChapter 3: Nurse Led Palliative Care for Advanced Cancer PatientsEmily J. Martin and Eric J. RoelandChapter 4: Benefits of Early Palliative Care to Informal Family CaregiversEmily J. Martin and Eric J. RoelandChapter 5: The Optimal Delivery of Palliative CareJaclyn Yoong and Peter PoonChapter 6: Availability and Integration of Palliative Care at US Cancer CentersPedro Pérez-Cruz and Alfredo Rodríguez-NúñezChapter 7: Cost Savings Associated with Palliative CareBreffni Hannon Section 2: Sympton Assessment and ManagementChapter 8: Changes in the Last Months of LifeJaclyn Yoong and Fiona RunacresChapter 9: The Edmonton Symptom Assessment System (ESAS)Breffni HannonChapter 10: Reversibility of Delirium in Palliative CareTiffany Shaw and Eric PrommerChapter 11: Multi-Component Intervention to Prevent Delirium in Hospitalized Older PatientsPeter LawlorChapter 12: Haloperidol, Chlorpromazine, and Lorazepam for DeliriumAnna Cecilia Tenorio and Maxine de la CruzChapter 13: Decompressive Surgery for Malignant Spinal Cord CompressionEsmé Finlay and Diaa OsmanChapter 14: Opioid Rotation for Toxicity ReductionAnna Cecilia Tenorio and Akhila ReddyChapter 15: Duloxetine for Chemotherapy-Induced Peripheral NeuropathyRebecca Burke and Akhila ReddyChapter 16: Effects of Morphine on DyspneaArif H. Kamal and Jason A. WebbChapter 17: Palliative Oxygen Versus Room Air for Refractory DyspneaJason A. Webb and Arif H. KamalChapter 18: Exercise for the Management of Cancer-Related FatigueLynn A. Flint and Eric WideraChapter 19: Reduction of Cancer-related Fatigue with Dexamethasone: a Double-Blind, Randomized, Placebo-Controlled Trial in Patients with Advanced CancerChirag A. PatelChapter 20: Parenteral Hydration in Patients with Advanced CancerCarlos Eduardo Paiva and Bianca Sakamoto Ribeiro PaivaChapter 21: Enteral Tube Feeding Dysphagic Stroke PatientsFrancisco Loaiciga and Rony Dev Chapter 22: Feeding Tube and Survival Among Patients With Severe Cognitive ImpairmentClaudio AdileChapter 23: Parenteral Nutrition in Cancer Patients Undergoing ChemotherapyFrancisco Loaiciga and Rony DevChapter 24: Docusate and Sennosides for ConstipationShalini DalalChapter 25: Treatment of Opioid-Induced Constipation in Advanced IllnessDonna S. ZhukovskyChapter 26: Octreotide for Malignant Bowel ObstructionShalini Dalal Section 3: Psychosocial Aspects of Care and CommunicationChapter 27: Prevalence of Mood Disorders in Patients with CancerLinh NguyenChapter 28: Dignity Therapy for Patients Near the End-of-LifeMarvin Omar Delgado-GuayChapter 29: Association between Spirituality/Religiosity and Quality of End-of-Life CareMarvin Omar Delgado-GuayChapter 30: The Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments (SUPPORT)Nathan A. Gray and Thomas W. LeBlanc Chapter 31: Doctors' Prognostic Accuracy in Terminally Ill PatientsAnjali Desai and Andrew S. EpsteinChapter 32: Prognostic Disclosure to Patients with Advanced CancerDavid HuiChapter 33: Expectations about Effects of Chemotherapy in Patients with Advanced CancerRajiv Agarwal and Andrew S. EpsteinChapter 34: Physician Message and Patient's Perception of CompassionLynn A. Flint and Eric Widera Section 4: End of Life Care and PlanningChapter 35: Association between Advance Directives and Quality of End-of-Life CareDonna S. ZhukovskyChapter 36: Outcomes Associated with End-of-Life DiscussionsMasanori MoriChapter 37: End-of-Life Discussions and Aggressiveness of Care Received Near DeathYael Schenker and Justin YuChapter 38: A Communication Intervention in the Intensive Care UnitLori Olson and Christian T. SinclairChapter 39: Clinical Signs of Impending Death in Cancer PatientsMasanori MoriChapter 40: Factors Considered Important at the End of LifeRavi B. Parikh and Oreofe O. OdejideChapter 41: Quality End-of-Life Care: Patients' PerspectivesJesse A. Soodalter and Yael SchenkerChapter 42: Family Perspectives on Aggressive End-of-Life CareRavi B. Parikh and Oreofe OdejideChapter 43: Family Perspectives on End-of-Life Care at the Last Place of CareEsmé Finlay and Erin FitzGeraldChapter 44: Liverpool Care Pathway for Hospitalized Cancer PatientsCarlos Eduardo Paiva and André Filipe Junqueira dos SantosChapter 45: Palliative Sedation Therapy and SurvivalJoseph ArthurChapter 46: What Patients and Families Want to Know About HospiceRegina Mackey and Kimberson TancoChapter 47: The Impact of Hospice on Mortality of Widowed SpousesKimberson Tanco and Regina MackeyChapter 48: Attitudes and Desires of Terminally Ill Patients Regarding Euthanasia and Physician-Assisted SuicideYu Jung KimChapter 49: Factors associated with Outcomes of Cardiopulmonary ResuscitationDutt Mehta and Eric PrommerChapter 50: Influence of Survival Probability on Preference for CPRChristian T. Sinclair and Allison E. Jordan

This book will be useful to any doctors or nurses studying palliative care, both as an introduction to the evidence base, such as it is, and to some of the questions still to be sorted out.