50 Studies Every Palliative Care Doctor Should Know

Dr. David Hui, MD, MSc is an Associate Professor in the Department of Palliative Care, Rehabilitation, and Integrative Medicine, with a joint appointment to the Department of General Oncology at The University of Texas MD Anderson Cancer Center, Houston, Texas. He completed his medical oncology training at the British Columbia Cancer Agency in British Columbia, Canada, and completed a palliative oncology fellowship at the University of Texas MD Anderson Cancer Center. His research interests include integration of supportive/palliative care into oncology practice, clinical trials investigating interventions for symptom control, and prognostication.Dr. Akhila Reddy, MD is an Associate Professor in the department of Palliative, Rehabilitation, and Integrative Medicine at The University of Texas MD Anderson Cancer Center in Houston, Texas. Her research interests include opioids, opioid induced neurotoxicity and pain management in cancer patients. She has authored several publications determining safe and effective opioid rotation ratios for pain management in cancer patients.One of the pioneering members of the hospice and palliative medicine movement in North America, Dr. Eduardo Bruera, MD has educated generations of hospice and palliative medicine clinicians. Founder of two of the leading palliative care programs in North America (in Edmonton, Canada and The University of Texas MD Anderson Cancer Center), his impact extends far beyond his direct trainees, many of whom have gone on to lead programs of their own nationally and internationally. Mentor to innumerable observers, visiting scientists, and mentees, he has contributed to the development of hospice and palliative medicine clinical and research expertise across the globe. A prolific physician scientist and sought after speaker, he has created an enduring legacy for the field.

• Section 1: Palliative Care Chapter 1: Early Palliative Care for Patients with Metastatic Non-Small Cell Lung Cancer Nathan A. Gray and Thomas W. LeBlanc Chapter 2: Early Palliative Care for Patients with Advanced Cancer David Hui Chapter 3: Nurse Led Palliative Care for Advanced Cancer Patients Emily J. Martin and Eric J. Roeland Chapter 4: Benefits of Early Palliative Care to Informal Family Caregivers Emily J. Martin and Eric J. Roeland Chapter 5: The Optimal Delivery of Palliative Care Jaclyn Yoong and Peter Poon Chapter 6: Availability and Integration of Palliative Care at US Cancer Centers Pedro Pérez-Cruz and Alfredo Rodríguez-Núñez Chapter 7: Cost Savings Associated with Palliative Care Breffni Hannon Section 2: Sympton Assessment and Management Chapter 8: Changes in the Last Months of Life Jaclyn Yoong and Fiona Runacres Chapter 9: The Edmonton Symptom Assessment System (ESAS) Breffni Hannon Chapter 10: Reversibility of Delirium in Palliative Care Tiffany Shaw and Eric Prommer Chapter 11: Multi-Component Intervention to Prevent Delirium in Hospitalized Older Patients Peter Lawlor Chapter 12: Haloperidol, Chlorpromazine, and Lorazepam for Delirium Anna Cecilia Tenorio and Maxine de la Cruz Chapter 13: Decompressive Surgery for Malignant Spinal Cord Compression Esmé Finlay and Diaa Osman Chapter 14: Opioid Rotation for Toxicity Reduction Anna Cecilia Tenorio and Akhila Reddy Chapter 15: Duloxetine for Chemotherapy-Induced Peripheral Neuropathy Rebecca Burke and Akhila Reddy Chapter 16: Effects of Morphine on Dyspnea Arif H. Kamal and Jason A. Webb Chapter 17: Palliative Oxygen Versus Room Air for Refractory Dyspnea Jason A. Webb and Arif H. Kamal Chapter 18: Exercise for the Management of Cancer-Related Fatigue Lynn A. Flint and Eric Widera Chapter 19: Reduction of Cancer-related Fatigue with Dexamethasone: a Double-Blind, Randomized, Placebo-Controlled Trial in Patients with Advanced Cancer Chirag A. Patel Chapter 20: Parenteral Hydration in Patients with Advanced Cancer Carlos Eduardo Paiva and Bianca Sakamoto Ribeiro Paiva Chapter 21: Enteral Tube Feeding Dysphagic Stroke Patients Francisco Loaiciga and Rony Dev Chapter 22: Feeding Tube and Survival Among Patients With Severe Cognitive Impairment Claudio Adile Chapter 23: Parenteral Nutrition in Cancer Patients Undergoing Chemotherapy Francisco Loaiciga and Rony Dev Chapter 24: Docusate and Sennosides for Constipation Shalini Dalal Chapter 25: Treatment of Opioid-Induced Constipation in Advanced Illness Donna S. Zhukovsky Chapter 26: Octreotide for Malignant Bowel Obstruction Shalini Dalal Section 3: Psychosocial Aspects of Care and Communication Chapter 27: Prevalence of Mood Disorders in Patients with Cancer Linh Nguyen Chapter 28: Dignity Therapy for Patients Near the End-of-Life Marvin Omar Delgado-Guay Chapter 29: Association between Spirituality/Religiosity and Quality of End-of-Life Care Marvin Omar Delgado-Guay Chapter 30: The Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments (SUPPORT) Nathan A. Gray and Thomas W. LeBlanc Chapter 31: Doctors' Prognostic Accuracy in Terminally Ill Patients Anjali Desai and Andrew S. Epstein Chapter 32: Prognostic Disclosure to Patients with Advanced Cancer David Hui Chapter 33: Expectations about Effects of Chemotherapy in Patients with Advanced Cancer Rajiv Agarwal and Andrew S. Epstein Chapter 34: Physician Message and Patient's Perception of Compassion Lynn A. Flint and Eric Widera Section 4: End of Life Care and Planning Chapter 35: Association between Advance Directives and Quality of End-of-Life Care Donna S. Zhukovsky Chapter 36: Outcomes Associated with End-of-Life Discussions Masanori Mori Chapter 37: End-of-Life Discussions and Aggressiveness of Care Received Near Death Yael Schenker and Justin Yu Chapter 38: A Communication Intervention in the Intensive Care Unit Lori Olson and Christian T. Sinclair Chapter 39: Clinical Signs of Impending Death in Cancer Patients Masanori Mori Chapter 40: Factors Considered Important at the End of Life Ravi B. Parikh and Oreofe O. Odejide Chapter 41: Quality End-of-Life Care: Patients' Perspectives Jesse A. Soodalter and Yael Schenker Chapter 42: Family Perspectives on Aggressive End-of-Life Care Ravi B. Parikh and Oreofe Odejide Chapter 43: Family Perspectives on End-of-Life Care at the Last Place of Care Esmé Finlay and Erin FitzGerald Chapter 44: Liverpool Care Pathway for Hospitalized Cancer Patients Carlos Eduardo Paiva and André Filipe Junqueira dos Santos Chapter 45: Palliative Sedation Therapy and Survival Joseph Arthur Chapter 46: What Patients and Families Want to Know About Hospice Regina Mackey and Kimberson Tanco Chapter 47: The Impact of Hospice on Mortality of Widowed Spouses Kimberson Tanco and Regina Mackey Chapter 48: Attitudes and Desires of Terminally Ill Patients Regarding Euthanasia and Physician-Assisted Suicide Yu Jung Kim Chapter 49: Factors associated with Outcomes of Cardiopulmonary Resuscitation Dutt Mehta and Eric Prommer Chapter 50: Influence of Survival Probability on Preference for CPR Christian T. Sinclair and Allison E. Jordan

This book will be useful to any doctors or nurses studying palliative care, both as an introduction to the evidence base, such as it is, and to some of the questions still to be sorted out.