30th European Symposium on Computer Aided Chemical Engineering

Sauro Pierucci is president and former vice president of AIDIC Servizi Srl, and a former professor in Chemical Engineering at CMIC Politecnico di Milano, where he also graduated in Chemical Engineering in 1969. He was member of EFCE (European Federation of Chemical Engineering) executive board until 2010. He has edited several international publications and is currently the editor-in-chief of the Chemical Engineering Transactions Journal, published by AIDIC, and the author of more than 200 scientific publications. In 2017, he was awarded by “the Dieter Behrens Medal” from EFCE. Flavio Manenti (Dipartimento di Chimica, Materiali e Ingegneria Chimica, Politecnico di Milano) is experienced in chemical process simulations for design and operational purposes. He developed AG2S™ technology for thermal conversion of CO2 and codeveloped BzzMath library. He is the author of peer-reviewed papers and books on the topic and is the President of the Computer Aided Process Engineering (CAPE) Working Party at the European Federation of Chemical Engineering. Giulia Bozzano is professor of Transport phenomena at CMIC Dept. “Giulio Natta” of Politecnico di Milano, Italy, Centre For Sustainable Process Engineering Reserach (SuPER), and secretary of CAPE Working Party of The European Federation Of Chemical Engineers (EFCE). She has authored 100+ papers indexed by main databases and filed patents and models applied on many industrial applications especially in the area of steam and thermal cracking of hydrocarbons and ammonia and methanol synthesis. She supervises M.Sc/Ph.D. students each year and she has led industrial and public projects on biomass treatment and biorefineries. Her research activity is associated to contracts with industry and public financing and faces with a wide variety of problems related to transport phenomena, reactor and kinetic modeling, process system engineering. Davide Manca received the M.Sc. in 1990 and the PhD in 1994, both on “Chemical Engineering” at Politecnico di Milano (POLIMI, Italy). He is professor of Process Systems Engineering and head of the PSE-Lab at POLIMI since 2002.He is (co)author of more than 210 peer-reviewed publications on international journals and conferences with a few book chapters.In more than twenty years of academic employment, he conjugated research activityand industrial advice to make these worlds better interact and get benefit from their mutual collaboration. At the basis of Davide’s research is the modeling activity that has the quantification of what is analyzed as the final target. Design, simulation, control, optimization, and assessment are the main features that use computer algorithms and methods to produce the quantification of phenomena, processes, and plants.Davide has taught Numerical Calculus, Dynamics and Control of Chemical Processes,Process Systems Engineering. He has been the supervisor of tens of students involved in the bachelor, master, and PhD degrees.He was founder and director of R&D and Engineering department at Virthualis, a spin- off company of POLIMI, working on operator training simulation in 3D immersive virtual environments.Under his direction, PSE Lab has worked on a number of European and Italian research projects with a fruitful collaboration with international universities and companies.

• PART AMODELLING AND SIMULATION1. Computer-aided Semi-empirical Model of Interphase Mass and Enthalpy Transfer in a Packed Column Distillation ProcessGoro Nishimura, Kunio Kataoka, Hideo Noda, Naoto Ohmura2. Methanol Kinetics from Optimal Dynamic ExperimentsCarsten Seidel, Achim Kienle3. Rigorous Modelling and Simulation of the Mass Transfer on the Trays of a Pilot Scale Distillation ColumnMayra Margarita May Vázquez, Fernando Israel Gomez Castro, Mario Rodriguez- Angeles4. Development of a Virtual Environment for the Rigorous Design and Optimization of Shell-and-tube Heat ExchangersOscar Lara-Montano, Fernando Israel Gomez Castro, Claudia Gutierrez-Antonio5. A Multiscale Modelling Approach for the Design of New Polymer MaterialsAlain Dequidt, Sebastien Garruchet, Benoit Latour, Nicolas Martzel, Ronald Blaak, Etienne Munch, Nicolas Seeboth, Patrice Malfreyt6. Structured and Unstructured (hybrid) Modeling in Precision MedicineLinas Mockus, Gintaras Victor Rex Reklaitis, Yuehwern Yih7. A Two Carriers Reactor Configuration for Packed Bed Chemical-looping for Power GenerationErasmo Mancusi, Piero Bareschino, Annunziata Forgione, Francesco Pepe8. Modeling of Liquid-liquid Phase Transfer Catalysis: Process Intensification via Integration of Process Systems Engineering and Computational ChemistryAbhimanyu Pudi, Adam Karcz, Vahid Shadravan, Martin Peter Andersson, Seyed Mansouri9. Investment Planning in Personalised MedicineDespoina Moschou, Maria Papathanasiou, Matthew Lakelin, Nilay Shah10. A Stochastic Modelling Approach to Describe the Effect of Drying Heterogeneity in the Lyophilisation of Pharmaceutical VaccinesGabriele Bano, Riccardo De-Luca, Emanuele Tomba, Fabrizio Bezzo, Massimiliano Barolo11. CFD Simulation of Film and Rivulet Flows on Microstructured SurfacesRene Bertling, Matthias Hack, Ilja Ausner, Marc Wehrli, Eugeny Kenig12. Energy Reduction Potential in Natural Gas Processing Through Heat and Process IntegrationMohamed El Amine Berchiche, Salah Belaadi, Gregoire Leonard 6713. An Adaptive Data-driven Modelling and Optimization Framework for Complex Chemical Process DesignThomas Savage, Hector Almeida-Trasvina, Ehecatl Antonio Del Rio Chanona, Robin Smith, Dongda Zhang14. Modelling and Optimisation of Middle Vessel Batch DistillationElena Catalina Udrea, Romuald Gyorgy, Costin Sorin Bildea15. Investigation of Heat Transfer Enhancement in a Microchannel Heat Sink with the Aid of Internal Fins: a Metamodel ApproachVahid Hosseinpour, Mohammad Kazemeini16. Optimization of Rfcc Process Considering Particle Deposition ModelHyungtae Cho, Kwang Cheol Oh, Jiheon Lee, Seokyoung Hong, Junghwan Kim17. Dimethyl Carbonate Production by Urea Transesterification, Process Simulation and Environmental AssessmentLaurent Astruc, Jose Miranda, Ivonne Rodriguez-Donis, Claire Vialle, Caroline Sablayrolles18. Modeling and Study of Hydrodynamic Flow within the Preneutralizer Reactor Using CFD ApproachSafae Elmisaoui, Lhachmi Khamar, Saad Benjelloun, Mohamed Khamar, Jean Michel Ghidaglia19. Modelling and Optimization of a Multi-regional Hydrogen Supply System: a Case Study of ChinaTianxiao Li, Pei Liu, Zheng Li20. A Hybrid Modelling Approach to Developing Digital Twins of an Ultra- supercritical Steam Turbine Control StageJianxi Yu, Pei Liu, Zheng Li21. Stochastic Analyses on Relative Viscosity of Water-in-oil EmulsionsAna Sousa, Maria Pereira, Henrique Matos22. Efficient Data-based Methodology for Model Enhancement and Flowsheet Analyses for Continuous Pharmaceutical ManufacturingPooja Bhalode, Nirupaplava Metta, Yingjie Chen, Marianthi Ierapetritou23. Artificial Neural Network to Capture the Dynamics of a Dividing Wall ColumnEduardo Sanchez Ramirez, Juan Gabriel Segovia-Hernandez, Esteban AbelardoHernández-Vargas24. An Optimal Design of Expansion-contraction Microchannel Based on Blockage AnalysisLin Wang, De Yan, Shuzhi Song, Jiarui Liu25. Comparative Study of Surrogate Modelling Techniques Applied to Three Different Chemical ProcessesRamon Mur, Ismael Diaz Moreno, Manuel Rodriguez Hernandez26. A Non-autonomous Relativistic Frame of Reference for Unit Operation DesignAndres Carranza-Abaid, Jana Jakobsen27. Evaluating the Transient Operation of Pcc for Fast Response Gas Turbines in a Future Low-carbon Energy SystemMathew Wilkes, Solomon Brown28. Increasing Power System Flexibility to Integrate High Share of Renewable EnergySiyuan Chen, Pei Liu, Zheng Li29. A Discrete Modeling Approach for Excess Gibbs-energy Models Combined with Molecular SamplingChristoph Mayer, Thomas Wallek30. Reliable Modelling of Twin-screw Extruders by Integrating the Backflow Cell Methodology into a Mechanistic ModelMaximilian Cegla, Sebastian Engell31. Comparison of Two Meta-heuristics for the Bi-objective Flexible Job Shop Scheduling Problem with Sequence Dependent Setup TimesJoao Sacramento, Joao Pedrosa, Nelson Chibeles-Martins, Tânia Pinto-Varela32. Simulation of the Crystallization Process Based on Cellular Automata --- Snowflake Formation from Pure Water SystemJianmin Liu, Jindong Dai, Chengyu Han, Junkai Zhang, Jiali Ai, Chi Zhai, Xiaolin Liu, Wei Sun33. A Thermo-economic Analysis Method for Combined Cycle Power Plants Under Flexible Operation ModesSenjing Qin, Pei Liu, Zheng Li34. Two-phase Flow Modelling and Simulation of Gas Purification ColumnLivia Gyurik, Attila Egedy, Tamas Varga, Zsolt Ulbert35. Parameters Influencing the Rate-based Simulation of CO2 Removal Units by Potassium Taurate SolventStefania Moioli, Minh T. Ho, Laura A. Pellegrini, Dianne E. Wiley36. Innovative Hybrid Energy System for Stable Power and Heat Supply in Offshore Oil & Gas Installation (hes-off): System Design and Grid StabilityLuca Riboldi, Erick Alves, Marcin Pilarczyk, Elisabetta Tedeschi, Lars Nord37. Nonlinear Prediction Model of Blast Furnace Operation StatusPourya Azadi, Saeid Ahangari Minaabad, Hauke Bartusch, Rainer Klock, Sebastian Engell38. CFD Simulation of a Solid-liquid Counter-current Screw ExtractorAnnemarie Lehr, Gábor Janiga, Andreas Seidel-Morgenstern, Dominique Thevenin39. Optimum Utilization of Jatropha Seedcake Considering the Energy, Water and Food NexusMohammad Alherbawi, Ahmed Alnouss, Gordon Mckay, Tareq Al-Ansari40. Potential Integrated Pathways for Jet Biofuel Production from Whole Fruit of JatrophaMohammad Alherbawi, Tareq Al-Ansari, Gordon Mckay41. Environmental Impacts of the Future German Energy System from Integrated Energy Systems Optimization and Life Cycle AssessmentChristiane Reinert, Sarah Deutz, Hannah Minten, Lukas Doerpinghaus, Sarah Von Pfingsten, Nils Baumgaertner, Andre Bardow42. A General Dynamic Model of a Complete Milk Pasteuriser Unit Subject to FoulingMengjia Zhu, Federico Lozano Santamaria, Sandro Macchietto43. A Nonsmooth Approach to Multicontaminant Mass and Water IntegrationCaroline Nielsen, Paul I. Barton44. Systematic Generation of a Robust Compartment Model for Counter-current Spray DryersBorja Hernandez, Mark A. Pinto, Mariano Martin45. Multiobjective Dynamic Optimization of Slow Freezing Processes for Human Induced Pluripotent Stem Cells by Modeling Intracontainer ConditionYusuke Hayashi, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama46. Optimal Design of a Non-isothermal Hybrid Catalyst Pellet Based on Pod-deim Reduced-order MethodologyKatarzyna Bizon, Gaetano Continillo47. Cyclopentane Purification from Multicomponent Azeotropic MixturesIntararit Nuchteera, Pairojpiriyakul Thirasak, M. Chavagorn, C. Thanyalak, Siemanond Kitipat48. Rigorous Simulation and Optimization of a Plant-wide Glycerol Carbonate (gc) Production ProcessBor-Yih Yu, Wei-Jen Chen49. Cfd-based Design Optimization of Air Quenching Equipment to Enhance the Cooling EffectJiwon Roh, Hyungtae Cho, Yeongryeol Choi, Hyundo Park, Il Moon, Junghwan Kim50. Integration of Computational Chemistry and Artificial Intelligence for Multi- scale Modeling of BioprocessesNima Nazemzadeh, Laura Wind Sillesen, Rasmus Fjordbak Nielsen, Mark Nicholas Jones, Krist V. Gernaey, Martin Peter Andersson, Seyed Mansouri51. Performance Enhancement of Acid Gas Cleaning Units in the Natural Gas Processing via Design ModificationUmer Zahid, Amr Al-Amri52. Profitability Increase of a Formaldehyde PlantAna Catarina Braz, Jorge Rocha, Ricardo Alvim, Henrique Matos53. Automatic Improved Hybrid Scheduling and Worker-task Allocation Method Applied to Multi-purpose Production PlantsRaul Calvo-Serrano, Matteo Abaecherli, Ruben Jungius, Thomas Kreuzer, Gonzalo Guillen-Gosalbez54. Efficient Amine-based Carbon Capture in a Power-to-jet Process Under Varying Renewable Electricity SupplyMahmoud Mostafa, Christopher Varela, Elvis Ahmetovic, Edwin Zondervan55. Analysis and Optimization of Carbon Supply Chains Integrated to a Power to Gas Plant in ItalyGrazia Leonzio, Edwin Zondervan56. Effect of Selective Size Extraction of Microalgae from a PhotobioreactorErgys Pahija, Chi-Wai Hui, John M. Woodley, Gurkan Sin57. Numerical Modelling for Environmental Impact Assessment of Sediment Dispersion in Port AreasStefania Magri, Patrizia De Gaetano, Alessandra Feola, Iolanda Lisi, Andrea Salmeri, Francesco Venti, Andrea Pedroncini58. An Efficient Hybridization of Gaussian Processes and Clustering for Electricity Price ForecastingAaron Steven Yeardley, Diarmid Roberts, Robert Milton, Solomon Brown59. CFD Analysis of the Use of Desert Sand as Thermal Energy Storage Medium in a Solar Powered Fluidised Bed Harvesting UnitMustapha Hamdan, Daniel Sebastia-Saez, Malak Hamdan, Harvey Arellano-Garcia60. Model of Spray-drying for Encapsulation of Natural ExtractsAndrea Bassani, Francesco Rossi, Cecilia Fiorentini, Guillermo Duserm Garrido, Gintaras Victor Rex Reklaitis, Irene Bonadies, Giorgia Spigno61. Modelling and Simulation of Low Pressure Carburizing FurnacesFatima Matamoros Marin, Pierre-Alexandre Glaude, Roda Bounaceur, Hubert Monnier, Abderrazak M. Latifi62. Thermodynamic Analysis of Different Methanation Reactors for Biogas UpgradingSayed Ebrahim Hashemi, Kristian M. Lien, Sondre K. Schnell, Bjorn Austbo63. Optimisation of Energy Consumption in a Medium-scale Reverse Osmosis Brackish Water Desalination PlantAlanood Alsarayreh, Mudhar Al-Obaidi, Amro Al-Hroub, Raj Patel, Iqbal Mujtaba64. Minimisation of Energy Consumption via Optimisation of a Simple Hybrid System of Multi Effect Distillation and Permeate Reprocessing Reverse Osmosis Processes for Seawater DesalinationOmer Al-Hotmani, Mudhar Al-Obaidi, Y. M. John, Raj Patel, Flavio Manenti, Iqbal Mujtaba65. Modelling and Performance Evaluation of Humidification-dehumidification Desalination Plant with Column Packing of Various TexturesDamson Kaunga, Raj Patel, Iqbal Mujtaba66. Application Domain Discovery of Thermodynamic Models by Mixture of Experts LearningOmar Hamadi, Tamas Varga, Janos Abonyi67. Kinetics Study on Removal of Cadmium from WastewaterHaya Alyasi, Hamish Mackey, Gordon Mckay68. Cost-effective Processes of Solar District Heating System Based on Optimal Artificial Neural NetworkMohamed Abokersh, Manel Valles Valles, Laureano Jimenez, Dieter Boer69. Packed-bed and Microchannel Reactors for the Reactive Capture of CO2 within Power-to-methane (p2m) Context: a ComparisonSantiago Ortiz, Camilo Rengifo, Martha Cobo, Manuel Figueredo70. Design and Eco-techno-economic Analyses of Sofc / Gas Turbine Hybrid Systems Accounting for Long-term DegradationHaoxiang Lai, Nor Farida Harun, David Tucker, Thomas Alan Adams Ii71. Analysis of the Effect of the Ceramic Membrane Module Based on Ebsilon Software on Water Recovery of Flue Gas from Coal-fired Power PlantsChao Jiang, Chenhui Jia, Pei Liu, Zheng Li72. Multi-objective Optimization Under Uncertainty of Novel Chpc ProcessDaniele Previtali, Francesco Rossi, Gintaras Victor Rex Reklaitis, Flavio Manenti73. Multi-objective Dynamic Optimisation of Ampicillin Batch CrystallisationAntonios Dafnomilis, Samir Diab, Alistair Rodman, Andreas Boudouvis, Dimitrios Gerogiorgis74. Reliability Estimation for Sensor Networks in Chemical Plants Using Monte Carlo MethodsJose Hernandez, Carolina Salto, Gabriela Minetti, Mercedes Carnero, Mabel Sánchez75. Low Temperature Applications for CO2 Capture in Hydrogen ProductionDonghoi Kim, David Berstad, Rahul Anantharaman, Julian Straus, Thijs Peters, Truls Gundersen76. Development and Application of Simulation-based Methods for Engineering Optimization Under UncertaintyAtli Freyr Magnusson, Resul Al, Gurkan Sin77. An Application of Computer Vision for Optimal Sensor Placement in Drop PrintingAndrew Radcliffe, Gintaras Victor Rex Reklaitis 45778. Livestock Production Planning with Batch-lines in the Agriculture IndustryBrenno Menezes, Jeffrey Kelly, Tareq Al-Ansari 46379. Ethanol Reforming: Setting Up Performance TargetShahid Ansari, Baraka Sempuga, Xinying Liu 46980. Thermodynamic Framework for Cryogenic Carbon CaptureLaura A. Pellegrini, Giorgia De Guido, Stefania Ingrosso81. Investigation of a Hybrid Approach to Find all Solutions of Nonlinear Equation SystemsSaskia Bublitz, Erik Esche, Jens-Uwe Repke82. Fast and Accurate Simulation of Simulated Moving Bed Chromatographic Processes with Linear Adsorption IsothermsRojiar Pishkari, Achim Kienle83. Efficient Parameterization of a Surrogate Model of Molecular Interactions in CrystalsDavid Bowskill, Isaac Sugden, Neil George, Adam Keates, Jennifer Webb, Constantinos Pantelides, Claire S. Adjiman84. Computational Fluid Dynamics Simulation of CO2 Methanation in a Fixed-bed Profile ReactorSteffen Flaischlen, Jan Martin, Bjarne Kreitz, Thomas Turek, Gregor D. Wehinger85. Data-driven Approach for Predictive Modeling of By-product Formation in Methanol SynthesisTibor Svitnic, Nga Do, Timm Schuhmann, Thomas Renner, Stephane Haag, Evrim Ors86. Modeling of the Solid Oxide Fuel Cell Considering H2 and CO Electrochemical ReactionsJia-Lin Kang, Chien-Chien Wang, Po-Hsun Chang, David Shan Hill Wong, Shi- Shang Jang, Chun-Hsiu Wang87. Design Optimization of C3mr Natural Gas Liquefaction ProcessPavan Veldandi, Sunjay Kurian88. A Practical Application of Simulation-based Surrogate Modeling for Prereformer ReactorRobin Schmidt, Amelie Chattot, Amal Bouchrit, Moein Mighani, Evrim Ors89. Development of a Microkinetic Model for the CO2 Methanation with an Automated Reaction Mechanism GeneratorBjarne Kreitz, Gregor D. Wehinger, Franklin Goldsmith, Thomas Turek90. Custom-made Temporomandibular Joint Mechanical Simulation: Different Fixation PatternAnita Gaia Mazzocco, Andre Luiz Jardini, Elifas Levy Nunes, Rubens Maciel Filho91. Cluster Analysis of Crude Oils Based on Physicochemical PropertiesAndre Sancho, Jorge Ribeiro, Marco Reis, Fernando Martins92. Optimization and Control of a Rainwater Detention and Harvesting TankQiao Yan Soh, Edward O'Dwyer, Salvador Acha, Nilay Shah93. Modelling and Simulation of Methanol Production and Conversion into Various Chemical Intermediates and ProductsLetitia Petrescu, Stefan-Cristian Galusnyak, Dora-Andreea Chisalita, Calin-Cristian Cormos94. Evaluating the Existing Protocol for Lng Bunkering OperationsAruna Coimbatore Meenakshi Sundaram, Karimi Iftekhar Abubakar95. A Recycle Model of Spent Liquor in Pre-treatment of Lignocellulosic BiomassFranco Mangone, Soledad Gutierrez96. Promo-a Multi-disciplinary Process Modelling SuiteHeinz A Preisig97. Performance Evaluation of Solid Oxide Fuel Cell Coupling to Biogas Tri- reforming with Installation of Hydrogen-selective Membrane SeparatorDang Saebea, S. Soisuwan, Yaneeporn Patcharavorachot98. A Grain-scale Study of Swelling Composite Porous Media Made of Fibres and ParticlesTommaso Santagata, Roberto Solimene, Gilberto Aprea, Piero Salatino99. Assessing the Sensitivity of Technical Performance of Three Ethanol Production Processes Based on the Fermentation of Steel Manufacturing Offgas, Syngas and a 3:1 Mixture Between H2 and CO2Eduardo F. Almeida, Henk Noorman, Rubens Maciel Filho, John A. Posada100. Techno-economic and Environmental Assessment of Electrofuels: a Case Study of Gasoline Production Using a Pem ElectrolyserDiego Freire Ordonez, Gonzalo Guillen-Gosalbez101. Dynamic Simulation of Chemical Looping Combustion in Packed Bed ReactorsVlad-Cristian Sandu, Calin-Cristian Cormos, Ana-Maria Cormos102. Life Cycle Analysis of Phenol - Formaldehyde Resins Substituted with LigninOlivia Ana Perederic, Aikaterini Mountraki, Electra Papadopoulou, John M. Woodley, Georgios M. Kontogeorgis103. Transport Model of Fluids Injected in a Landfill Polluted with Lindane WastesDavid Lorenzo, Aurora Santos, Carmen M. Dominguez, Joaquin Guadano, Jorge Gomez, Jesus Fernández104. Modeling and Optimization for Short-term Scheduling of Plastic Bag PlantsMyrian Gabriela Santos Torres, Jose Alberto Bandoni, Marta Susana Moreno105. Analysis of an Industrial Adsorption Process Based on Ammonia Chemisorption: Modeling and SimulationCristian Cardenas, Stephanie Marsteau, Lea Sigot, Cecile Vallieres, Abderrazak M. Latifi106. Propagation of Parametric Uncertainty in a Conceptually Designed Bioethanol Production ProcessDilara B. Yıldız, Nihat A. Sayar107. New set of Graphical Axes for Grassroots Design of Heat Exchanger Networks for Chemical Engineering ApplicationsDina Kamel, Mamdouh Gadalla, Fatma Ashour108. A Novel Process for Dimethyl Ether Synthesis Using Inter-stage Ceramic Membrane for Water RemovalAbdulrahman Al-Rabiah109. Computer-aided Solvent Mixture Design for the Crystallisation and Isolation of Mefenamic AcidSuela Jonuzaj, Oliver L. Watson, Sara Ottoboni, Chris J. Price, Jan Sefcik, Amparo Galindo, George Jackson, Claire S. Adjiman110. Direct Dme Synthesis from Syngas: a Technoeconomic Model-based InvestigationAndrea Bernardi, Yuchu Chen, David Chadwick, Benoit Chachuat111. Microbial Pb(ii) Precipitation: Kinetic Modelling of Pb(ii) Removal and Microbial GrowthCarla Horstmann, Deon Brink, Evans Chirwa112. Optimization of a Cyclone Reactor for Biomass Hydropyrolysis Through Global Sensitivity Analysis and Stochastic OptimizationYris Gonzalez, Wilfredo Angulo, Dany De Cecchis, Maria Lucena, Santiago D Salas113. Dynamic Modeling for Phb Production Based on Linear Mfa and Measurements from Batch FermentationAdriana C. Torres Ospina, Carlos A. M. Riascos114. A Methodological Design Framework for Hybrid "power-to-methane" and "power-to-hydrogen" Supply Chains: Application to Occitania Region, FranceEduardo Carrera Guilarte, Catherine Azzaro-PantelPART B115. A Two-stage Stochastic Programming Model to Determine the Optimal Screening Strategy for Colorectal CancerDavid Young, Selen Cremaschi116. Beyond Opospm: a Corrected Maximum Entropy Weibull Distribution for Solving Population BalancesMenwer Attarakih, Hans-Jörg Bart117. The Effect of Age on the Delivery of Intravenous Anesthesia: a Physiologically- based Modeling Approach to Pediatric PatientsDaniel Salis, Adriana Savoca, Davide Manca118. Physiologically-based Pharmacokinetic and Pharmacodynamic Modeling of Unfractionated Heparin to Predict Activated Clotting TimeFilippo Regorda, Emiliano Vigoni, Giuseppe Pesenti, Marina Pieri, Alessandro Belletti, Davide Manca119. Application of a Pharmacokinetic Model to Inform the Optimal Dose for Individualized Drug AdministrationGiuseppe Pesenti, Marco Foppoli, Adriana Savoca, Davide Manca120. Energy-efficient Solvent Properties for the Post-combustion Carbon Dioxide CaptureJin He, Pei Liu, Zheng Li121. The Role of Process Engineering in the Digital TransformationNorbert JungSYNTHESIS AND DESIGN122. A Mixed Integer Nonlinear Approach for the Automated Superstructure Generation ProblemLuca Mencarelli, Alexandre Pagot123. Rational Design of Ion Exchange Simulated Moving Bed ProcessesMarcus Fechtner, Achim Kienle124. Optimal Use of Process Streams as Working Fluids in Work and Heat Exchange Networks (whens)Haoshui Yu, Chao Fu, Truls Gundersen, Emre Gencer125. Computer Aided Molecular Design of Green Solvents for the Hydroformylation of Long-chain OlefinesTobias Kessler, Christian Kunde, Steffen Linke, Kevin McBride, Kai Sundmacher, Achim Kienle126. Integration of Design and Operation Using Dynamic Perturbation and Chance Constraints with Unscented TransformChristian Hoffmann, Joris Weigert, Erik Esche, Jens-Uwe Repke 751127. Modelling of Organophilic and Hydrophilic Pervaporations for Separation of Ethyl Acetate – Water MixtureAndras Jozsef Toth, Eniko Haaz, Reka Ladanyi, Botond Szilagyi, Daniel Fozer, Asmaa Selim, Tibor Nagy, Peter Mizsey128. Superstructure Optimization for the Design of a Desalination Plant to Tackle the Water Scarcity in Texas (usa)Marcello Di Martino, Styliani Avraamidou, Efstratios N. Pistikopoulos129. Optimal Design of a Multi-product Polycrystalline Silicon FacilityCesar Ramirez-Marquez, Edgar Martin-Hernandez, Mariano Martin, Juan Gabriel Segovia-Hernandez130. Synthesis and Optimization of a Furfural Production Process. a Case Study of Mexico Considering Different Lignocellulosic FeedstocksGabriel Contreras-Zarazua, Mariano Martin, Eduardo Sanchez Ramirez, Juan Gabriel Segovia-Hernandez131. Heat Exchanger Network Retrofit for Processes with Multiple Operating Cases: a Metaheuristic ApproachJan A. Stampfli, Donald G. Olsen, Beat Wellig, Rene Hofmann132. Sustainable Process Synthesis, Design and Innovation of Bio-succinic Acid ProductionRofice Dickson, Enrico Mancini, Nipun Garg, Jay Liu, Manuel Pinelo, Seyed Mansouri133. Optimal Design of Macroalgae-based Integrated Biorefinery: Economic and Environmental PerspectiveRofice Dickson, Jun-Hyung Ryu, Jay Liu134. Integrating Superstructure Optimization Under Uncertainty and Optimal Experimental Design in Early Stage Process DevelopmentStefanie Kaiser, Sebastian Engell135. A Thermodynamic Approach for Simultaneous Solvent and Process Design of Continuous Reactive Crystallization with RecyclingNethrue Mendis, Jiayuan Wang, Richard Lakerveld136. Synthesis of Complex Distillation Sequences with Multiple FeedsJose A. Caballero, Juan A. Reyes-Labarta, Juan Javaloyes-Anton137. Integrating Suppliers into the Simultaneous Process and Product Design of Formulated ProductsManuel Taifouris, Mariano Martin, Alberto Martinez, Nats Esquejo138. Modeling Framework Forjoint Product and Process Synthesis with Material Recovery OpportunitiesAna Somoza-Tornos, Qi Chen, Moises Graells, Antonio Espuna, Ignacio E. Grossmann139. Value Chain Synthesis in Algae Biorefineries Under UncertaintyMelina Psycha, Lorenzo-Andreas Mamos, Antonis Kokossis140. Effect of Flue Gas Composition on the Design of a CO2 Capture PlantAna Gabriela Romero-Garcia, Nelly Ramirez-Corona, Eduardo Sanchez Ramirez, Heriberto Alcocer-García, Juan Gabriel Segovia-Hernandez141. Deterministic Global Optimization of Multistage Membrane Gas Separation Using Surrogate ModelsMarius Hoernschemeyer, Christian Kunde142. An Innovative and Fully Automated System for Gel Electrophoresis Konstantinos Theodoridis, Fotios Stergiopoulos, Dimitrios Bechtsis, Nikolaos Nikolaidis, Dimitrios Triantafillides, Apostolos Tsagaris, Anastasios Filelis, Asterios Papaikonomou143. Integrated Design of Process Configuration and Scheduling for Hydrogen Peroxide Decontamination in Biopharmaceutical Injectable ManufacturingKeisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama144. Social Life Cycle Assessment of Pulp and Paper Production-a Portuguese Case StudyAndreia Santos, Catherine Norris, Ana Paula Barbosa-Povoa, Ana CarvalhO145. Determining the Design Parameters of Reactive Distillation Processes by a Quick Mapping MethodRahma Muthia, Megan Jobson, Anton Alexandru Kiss146. Conceptual Design Based on Superstructure Optimization in Gams with Accurate Thermodynamic ModelsDavid Krone, Erik Esche, Norbert Asprion, Mirko Skiborowski, Jens-Uwe Repke147. A Multiperiod Approach for Flexible Work and Heat IntegrationLeandro Pavao, Mauro Antonio Da Silva Sá Ravagnani, Caliane Costa148. Multi-objective Evolutionary Algorithm Based on Decomposition (moea/d) for Optimal Design of Hydrogen Supply ChainsVictor Cantu, Catherine Azzaro-Pantel, Antonin Ponsich149. Integrated in Silico Design of Catalysts and Processes Based on Quantum ChemistryChristoph Gertig, Lorenz Fleitmann, Carl Hemprich, Janik Hense, Andre Bardow, Kai Leonhard150. In Silico Screening of Metal-organic Frameworks for Acetylene/ethylene SeparationYageng Zhou, Teng Zhou, Kai Sundmacher151. Process Synthesis and Simultaneous Heat and Electricity Integration to Reduce Consumption of Primary Energy SourcesAndreja Nemet, Timothy Gordon Walmsley, Elvis Ahmetovic, Zdravko Kravanja152. Coproduction of Ethylene and Propylene Based on Ethane and Propane FeedstocksAlejandro Pedrozo, Belen Rodriguez Reartes, Maria Soledad Diaz, A. R. Vecchietti, Ignacio E. Grossmann153. Circular Economy Analysis of Helium Recovery from Sales Gas ProductAhmed Alnouss, Saad Al-Sobhi154. Optimal Design and Operation of Flexible Polygeneration Systems Using Decomposition AlgorithmsAvinash Shankar Rammohan Subramanian, Thomas Alan Adams Ii, Truls Gundersen, Paul I. Barton155. Computational Shape Optimization of Microreactors Based on CFD Simulation and Surrogate Model Driven OptimizationRunzhe Liang, Zhihong Yuan156. High-purity Dmc Production by Indirect Alcoholysis of Urea: Optimal Design and ControlIulian Patrascu, Costin Sorin Bildea, Anton Alexandru Kiss157. Optimization of Shell and Tube Heat Exchangers Sizing with Heat Transfer EnhancementZekun Yang, Yingjie Ma, Nan Zhang, Robin Smith158. The Evaluation of Combined Heat and Mass Exchanger Network Synthesis Using Novle Stage-wise SuperstructureEleonora Amelia, Siemanond Kitipat, Saura Pierucci, Flavio Manenti, Giulia Bozzano, Davide Manco159. An Improved Superstructure-based Model for Integrating an Organic Rankine Cycle into Total SiteZheng Chu, Nan Zhang, Robin Smith160. MINLP Synthesis of Flexible Process Flow Sheets Under Variable Carbon Tax RatesKlavdija Zirngast, Zdravko Kravanja, Zorka Novak Pintaric161. Design Space Investigation for Development of Continuous Flow Syntheses of Active Pharmaceutical IngredientsSamir Diab, Dimitrios Gerogiorgis162. Optimization of Liquid Air Energy Storage (laes) Using a Genetic Algorithm(ga)Zhongxuan Liu, Haoshui Yu, Truls Gundersen163. Sensitivity Analysis of Desulfurization Costs for Small-scale Natural Gas Sweetening UnitsYushi Deng, Shuang Xu, Kylie Webb, Harrison Wright, Paul Dimick, Selen Cremaschi, Mario Eden164. Synthesis of Heat Pump Enhanced Solar Thermal for Low and Medium Temperature OperationsBen Abikoye, Lidija Cucek, Danijela Urbancl, Adeniyi Isafiade, Zdravko Kravanja165. Protein from Renewable Resources: Mycoprotein Production from Agricultural ResiduesThomas Upcraft, Rob Johnson, Tim Finnigan, Jason Hallett, Miao Guo166. Energy Efficient Distillation by Combination of Thermal Coupling and Heat IntegrationMirko Skiborowski167. Optimization-based Design of Rotating Packed Beds with Zickzack PackingsKai Kruber, Hina Qammar, Mirko Skiborowski168. Design Concepts for Pressurized Lng Storage TanksMarian Krol169. utomatic Synthesis of Distillation Processes for the Separation of Heterogeneous Azeotropic Multi-component MixturesThulasi Sasi, Kai Kruber, Moreno Ascani, Mirko Skiborowski170. Technical and Economic Feasibility of Direct Methane Conversion for Hydrocarbon Production: Process Design and Techno-economic AnalysisThai Ngan Do, Yong Tae Kim, Jiyong Kim171. 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