The Handbook of Dopamine

Dr. Stephanie Cragg is a professor of neuroscience at Oxford University. She runs a laboratory on understanding dopamine neurotransmission. Dr. Mark Walton is currently a professor of behavioral neuroscience at Oxford University. His laboratory, the Walton Lab, researches how value is learned and influences decision making within defined brain systems.

• Section 1: Development, diversity, and connectivity1. The dopamine system from an evolutionary perspectiveSten Grillner and Brita Robertson2. Molecular heterogeneity of midbrain dopamine neuronsRajeshwar Awatramani and Jean-Francois Poulin3. Building an action circuit with nigrostriatal dopaminergic neurons and striatonigral neuronsHuaibin Cai and Charles Gerfen4. Anatomy of dopamine neuron projections: Axonal arbors, varicosities, and synapsesLouis-Eric Trudeau and Raphaelle Denis5. Dopamine neuron connectomes: Inputs and outputsMitsuko Watabe-Uchida and Ryunosuke AmoSection 2: Dopamine neuron physiology and dopamine release regulation6. Electrical patterns of activity in dopamine midbrain neurons in vivoJochen Roeper, Birgit Liss, Zayd Khaliq, and Carmen C. Canavier7. Computational modeling of midbrain dopamine neuronsCarmen C. Canavier, Christopher Knowlton, Birgit Liss, Zayd Khaliq, and Jochen Roeper8. Axonal dopamine release: Molecular mechanismsPascal S. Kaeser9. Somatodendritic dopamine releaseMargaret E. Rice, Takuya Hikima, Paul Witkovsky, and Jyoti C. Patel10. Axonal regulation of dopamine transmission by striatal neuromodulatorsStephanie J. Cragg, David Sulzer, and Kathryn Todd11. Dopamine transporters and the nanoscale organization of the dopamine axonAske Lykke Ejdrup, Matthew Lycas, Freja Herborg, and Ulrik Gether12. Beyond dopamine: Cotransmission by dopamine neuronsRiccardo Melani and Nicolas X. TritschSection 3: Dopamine signalling: Receptors, postsynaptic integration and plasticity13. Unveiling activation mechanisms and intrinsic divergence of dopamine receptors based on experimentally determined structuresSung Joon Won, Kuo Hao Lee, and Lei Shi14. Dopamine receptor drugs and their applicationsJ. Robert Lane and Alessandro Bonifazi15. Postsynaptic integration and plasticity in the striatumSho Yagishita16. Dopamine signaling roles in the extrastriatal basal gangliaJerome Baufreton17. Postsynaptic integration and plasticity in the prefrontal cortexPaul G. Anastasiades, Guillermo Gonzalez-Burgos, and Wen-Jun GaoSection 4: Dopamine mechanisms of learning and reinforcement18. The dopamine reward prediction error signalWolfram Schultz19. Diversity of encoding: Reward to aversionNaoshige Uchida, Mitsuko Watabe-Uchida, and Isobel Green20. Dopamine beyond temporal-difference reinforcement learningKaue Machado Costa and Geoffrey Schoenbaum21. Habits and dopamineJay Bertran-Gonzalez and Bernard W. Balleine22. Dopamine for performance evaluation—Insights from songbirdsVikram Gadagkar23. Striking parallels between the dopaminergic systems of flies and mammalsKristijan D. Jovanoski and Scott Waddell24. Reinforcement learning with dopamine: A convergence of natural and artificial intelligencePaul Masset and Samuel J. GershmanSection 5: Dopamine function in motivated behavior25. Dopamine and the temporal control of behaviorJoseph Paton26. Volition and vigorJoshua T. Dudman and Luke T. Coddington27. Why the new definition of “anhedonia” misses the mark on dopamine function: Studies of effort-based aspects of motivation and selection of voluntary physical activityJohn D. Salamone and Merce Correa28. Exploration and behavioral variabilityPhilippe Faure29. Role of dopamine in adaptively tuning motivational bias to the current environmentRoshan Cools, Hanneke E.M. Den Ouden, and Egbert Hartstra30. Sex differences in dopamine systems involved in motivation and rewardChristopher A. Turner, Noah Bass, Ivette L. Gonzalez, and Jill B. Becker31. Dopamine and appetiteCamila Saenz and Stephanie L. BorglandSection 6: Dopamine dysregulation: From neurology to psychiatry32. Neuronal design and determinants of selective neuronal vulnerability of dopaminergic neurons in Parkinson’s diseaseEnrico Zampese, James Moran, and D. James Surmeier33. Understanding human dopamine neuron biology in Parkinson’s patient cellsGizem Onal, Maria Claudia Caiazza, Parnaz Sharifi, Iona Thomas-Wright, Johanna L. Hoffmann, Rachel Heon-Roberts, and Richard Wade-Martins34. Dopamine replacement for Parkinson’s disease: Clinical approaches and experimentalunderpinningsM. Angela Cenci, Kristina Rosqvist, and Per Odin35. Dopamine modulation of synaptic transmission in drug addictionMaria Reva and Christian L €Uscher36. Molecular reprogramming of D1 and D2 dopaminoceptive medium spiny neurons in substance use disorderCaleb J. Browne and Eric J. Nestler37. Human dopamine systems in addiction disordersNora D. Volkow and Peter Manza38. Apathy and impulsivity in neurological and psychiatric disordersYoussuf Saleh and Masud Husain39. Dopamine dysfunction in psychosisRobert A. Mccutcheon and Chambrez-Zita Zauchenberger40. Dopamine systems in impulsive–compulsive behaviorTrevor W. Robbins and Jeffrey W. Dalley