Deepak Rawtani, M.E., PhD, Chartered Engineer, has over 21 years of extensive research experience spanning private and government organizations. He is an accomplished researcher with a focus on molecular medicine, discovery biology, and nanobiotechnology. His career includes roles at the Industrial Toxicology Research Centre, Lucknow; USV Limited, Mumbai; and Torrent Research Centre, Gandhinagar. His primary research areas include forensic nanobiotechnology, with a particular emphasis on DNA–nanoparticle interactions and the functionalization of halloysite nanotubes for applications such as enzyme immobilization, drug delivery, and environmental remediation. Dr. Rawtani has authored over 120 papers and seven books in nanotechnology and environmental science, published in AQ1, a reputable international journal and publisher. He has been recognized among the top 2% of researchers worldwide by Stanford University for 2021, 2022, and 2023. Additionally, he is a NABL-empaneled Technical Assessor (ISO/IEC 17025) with the Quality Council of India. Nitasha Khatri holds a graduate degree in Life Sciences, with postgraduate and MPhil qualifications in Biotechnology. She earned her PhD in Environmental Science, specializing in water pollution and management. With over 18 years of experience primarily in the environmental sector, she currently serves at Gujarat Environment Management Institute (GEMI) as a Senior Scientific Officer and Head of the Laboratory. Her active contributions span various areas of ecology, including biomonitoring with macroinvertebrates, nanotechnology-assisted bioremediation, rural environment management, conservation efforts, and source apportionment studies involving water, air, and soil monitoring and assessment. Dr. Khatri has authored more than 40 research papers published in international peer-reviewed journals. Chaudhery Mustansar Hussain, PhD, is an adjunct professor and director of laboratories in the Department of Chemistry & Environmental Sciences at the New Jersey Institute of Technology (NJIT), Newark, New Jersey, United States. His research is focused on the applications of nanotechnology and advanced materials, environmental management, analytical chemistry, and other various industries. Dr. Hussain is the author of numerous papers in peer-reviewed journals as well as a prolific author and editor of around 200 books, including scientific monographs and handbooks in his research areas. He has published with several reputable publishers including Elsevier.

• Section I: Fundamentals of Smart Halloysite Nanotubes1. Introduction to Mineralogy and Geology of Smart Materials2. Processing and Purification of Halloysite Nanotubes3. Physicochemical Properties of Halloysite Nanotubes4. Strategies for Derivatization and Functionalization of Halloysite Nanotubes5. Challenges of Derivatization of Halloysite Nanotubes6. Characterization of Intelligent Halloysite NanotubesSection II: Development of Hybrid Halloysite Nanotubes for Guest Molecules7. Development of a Receptive Surface of Halloysite Nanotubes for the Immobilization of Guest Molecules8. Selection of Hybrid Halloysite Nanotubes Based on Guest Molecules9. Fabrication Routes for Hybrid Halloysite Nanotubes Based on Guest Molecules10. Fabrication Strategies for Hybrid Halloysite Nanotubes Based on Guest Molecules-IISection III: Smart Halloysite Nanotubes as Green Alternative11. Halloysite Nanotubes as a Green Alternative for Functional Organic/Inorganic Nanohybrids-I12. Halloysite Nanotubes as a Green Alternative for Functional Organic/Inorganic Nanohybrids-IISection IV: Applications, Commercialization and Future Prospects of Smart Halloysite Nanotubes13. Halloysite Nanotube-based Drug Delivery Systems14. Hybrid Halloysite Nanotubes and their Role as Nanocontainers for Biomedical Applications15. Halloysite Nanotubes as Support Material for Enzyme Immobilization16. Tiny Tubes with Big Impact: Exploring the Potential of Halloysite Nanotubes for Food Packaging Applications—Recent Advancements17. Environmental Applications of Halloysite Nanotubes18. The Role of Halloysite Nanotubes as Fillers for Industrial Applications19. Halloysite Nanotube-based Polymers as Smart and Economical Flame-retardant Tools20. Future Prospects of Halloysite Nanotubes: A Road to Biomedical, Environmental, Food Packaging and Quality Monitoring Applications21. Commercialization Perspectives of Halloysite Nanotubes: From Rocks to Markets (Ceramics, Therapeutics, and Catalysis)Section V: Toxicity, Environment Fate, and Case Studies22. Halloysite Nanotubes as Emerging Multifunctional Materials for Environmental and Biomedical Applications23. Electrochemical Investigation of Halloysite/Iron Oxide-functionalized Graphitic Carbon Nitride Nanocomposites: A Case Study